Results 91 to 100 of about 1,823,262 (282)

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

Advanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo, Caian He, Xiao Xiao, Jingmeng Li, Zilong Zhang, Ying He, Chuanchuan Wang, Jiale Zhao, Jun Gong, Jiarui Liang, Tian Yuan, Haiting Sun, Xuebo Liu, Chao Gao, Zhigang Liu   +14 more
wiley   +1 more source

RNA-specific ribonucleotidyl transferases [PDF]

, 2007
RNA-specific nucleotidyl transferases (rNTrs) are a diverse family of template-independent polymerases that add ribonucleotides to the 3'-ends of RNA molecules.
Keller, W., Martin, G., W. Keller, G. Martin, Martin G, Keller W   +5 more
core   +1 more source

Comprehensive analysis of an lncRNA-miRNA-mRNA competing endogenous RNA network in pulpitis [PDF]

PeerJ, 2019
Background Pulpitis is a common inflammatory disease that affects dental pulp. It is important to understand the molecular signals of inflammation and repair associated with this process. Increasing evidence has revealed that long noncoding RNAs (lncRNAs)
Fangcao Lei, Han Zhang, Xiaoli Xie
doaj   +2 more sources

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

AFCMEasyModel: An Easy Interface for Modeling Competing Endogenous RNA Networks using ODEs

, 2017
Competing endogenous RNA networks have been considered to be important regulators of genetic data expression. Circular RNAs and microRNAs interact to form a circular sponge that have been shown to regulate messenger RNAs and hence regulating gene ...
Mohammad M. Tarek
core   +1 more source

Epigenetic regulation of endogenous plant pararetroviruses [PDF]

, 2005
This thesis focuses on epigenetic processes involved in the regulation of gene expression in endogenous pararetroviruses (EPRVs), exemplified by endogenous Petunia vein clearing virus (ePVCV-1) and its episomal form, PVCV. Since ePVCV-1/PVCV was found to
Noreen, Faiza
core   +1 more source

The Discovery of microRNA and Its Significance: The Enlightenment of The Nobel Prize in Physiology or Medicine of 2024

Shengwu huaxue yu shengwu wuli jinzhan
The 2024 Nobel Prize in Physiology or Medicine was awarded to American scientists Victor Ambros and Gary Ruvkun in recognition of their discovery of microRNA (miRNA) and its role in regulating gene expression at the post-transcriptional level. miRNA is a
LI Wen-Chao, XIAO Cheng-Feng, ZENG Zhao-Yang, XIONG Wei, QU Hong-Ke   +4 more
doaj   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Review of Computational Prediction of Competing Endogenous RNA

Journal of Proteomics & Bioinformatics, 2019
MicroRNAs (miRNAs) are the gene regulatory molecules that bind to microRNA response elements (MREs) in the 3’ untranslated regions (UTRs) of mRNAs. The repressive activity of miRNA is counteracted by “miRNA sponges” or “competing endogenous RNAs (ceRNAs)” termed because of its competing nature of sequestering miRNA’s effect.
Sherin K, Achuthsankar S. Nair
openaire   +1 more source

Long non-coding RNA-SNHG7 acts as a target of miR-34a to increase GALNT7 level and regulate PI3K/Akt/mTOR pathway in colorectal cancer progression

Journal of Hematology & Oncology, 2018
Background Colorectal cancer (CRC) arises in a multistep molecular network process, which is from either discrete genetic perturbation or epigenetic dysregulation.
Yang Li, Changqian Zeng, Jialei Hu, Yue Pan, Yujia Shan, Bing Liu, Li Jia   +6 more
doaj   +1 more source