Results 91 to 100 of about 238,324 (282)

Adaptable Covalent Organic Framework‐Hydrogel Microneedles for Glucose‐Responsive Isoliquiritigenin Delivery in Diabetic Wound Therapy

Advanced Healthcare Materials, EarlyView.
We develop a covalent organic framework‐loaded Traditional Chinese Medicine monomer nanodrug delivery system (ISL@bCOF) via boron‐oxygen bonds, a smart response to glucose for delivering AI‐driven isoliquiritigenin (ISL) targeting ZBP1. This dynamic release mechanism, combined with transdermal delivery technology via potent microneedles, can modulate ...
Menghan Zhou, Zongjie Hu, Xiuwen Li, Huaman Geng, Yang Liu, Yajie Wang, Yunshu Yang, Guangdong Zhou, Yujie Hua, Di Wang   +9 more
wiley   +1 more source

LAceModule: Identification of Competing Endogenous RNA Modules by Integrating Dynamic Correlation

Frontiers in Genetics, 2020
Competing endogenous RNAs (ceRNAs) regulate each other by competitively binding microRNAs they share. This is a vital post-transcriptional regulation mechanism and plays critical roles in physiological and pathological processes.
Xiao Wen, Lin Gao, Yuxuan Hu
doaj   +1 more source

Construction of a circular RNA-based competing endogenous RNA network to screen biomarkers related to intervertebral disc degeneration

BMC Musculoskeletal Disorders, 2022
Highlights 1. An IDD-related ceRNA network involving four circRNAs, three miRNAs and 11 mRNAs was constructed. 2. The expression levels of miR-185-5p, miR-486-5p, FOXO1, SMAD2 and TGFB1 were consistent in different databases. 3.
Bin Yu, Ziqi Zhu, Tao Hu, Jiawei Lu, Beiduo Shen, Tongde Wu, Kai Guo, Surendra Kumar Chaudhary, Hang Feng, Weidong Zhao, Desheng Wu   +10 more
doaj   +1 more source

Table_1_Long Noncoding Competing Endogenous RNA Networks in Pancreatic Cancer.docx

, 2021
Pancreatic cancer (PC) is a highly malignant disease characterized by insidious onset, rapid progress, and poor therapeutic effects. The molecular mechanisms associated with PC initiation and progression are largely insufficient, hampering the ...
Guangbing Xiong (3555230), Jikuan Jin (11601934), Feng Zhu (685), Xu Li (23864), Ruizhi He (5890487), Xiaoxiang Wang (379686), Renyi Qin (2831852), Shutao Pan (7143704), Min Wang (21070), Jianwei Zheng (1626523), Feng Peng (400899)   +10 more
core   +1 more source

High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue‐Resident Memory T Cells via Altering Skin Microbiota

Advanced Science, EarlyView.
We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang, Yuchao Chen, Chuanjian Lu, Huazhen Liu, Fenglian Qin, Sisi Dai, Feifei Qiu, Haiming Chen, Weihui Lu, Jonathan S. Bromberg, Zhenhua Dai   +10 more
wiley   +1 more source

Long non-coding RNA-SNHG7 acts as a target of miR-34a to increase GALNT7 level and regulate PI3K/Akt/mTOR pathway in colorectal cancer progression

Journal of Hematology & Oncology, 2018
Background Colorectal cancer (CRC) arises in a multistep molecular network process, which is from either discrete genetic perturbation or epigenetic dysregulation.
Yang Li, Changqian Zeng, Jialei Hu, Yue Pan, Yujia Shan, Bing Liu, Li Jia   +6 more
doaj   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Image1_Construction of lncRNA-Mediated Competing Endogenous RNA Networks Correlated With T2 Asthma.JPEG

, 2022
Background: Precise classification has been reported as a central challenge in the clinical research on diagnosis and prediction of treatment efficacy in asthma.
Zihan Wang (3129810), Yun Pan (285227), Jiawei Xu (394968), Tao Feng (43135), Dong Zhang (73558), Liang Dong (381161), Xinrui Qiao (9179146), Xiaofei Liu (72796), Jintao Zhang (846358), Wenjing Cui (296467)   +9 more
core   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Circular RNA PVT1 acts as a competing endogenous RNA for miR-497 in promoting non-small cell lung cancer progression

, 2019
Circular RNA PVT1 acts as a competing endogenous RNA for miR-497 in promoting non-small cell lung cancer ...
Yue Zhao (186573), Xueli Zhang (383859), Hongjing Lin (17812382), Xiaohong Zhang (32960), Gwanyong Lim (17812379), Si Qin (3627863)   +5 more
core