Results 101 to 110 of about 1,823,262 (282)

LAceModule: Identification of Competing Endogenous RNA Modules by Integrating Dynamic Correlation

Frontiers in Genetics, 2020
Competing endogenous RNAs (ceRNAs) regulate each other by competitively binding microRNAs they share. This is a vital post-transcriptional regulation mechanism and plays critical roles in physiological and pathological processes.
Xiao Wen, Lin Gao, Yuxuan Hu
doaj   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

Circular RNA PVT1 acts as a competing endogenous RNA for miR-497 in promoting non-small cell lung cancer progression

, 2019
Circular RNA PVT1 acts as a competing endogenous RNA for miR-497 in promoting non-small cell lung cancer ...
Yue Zhao (186573), Xueli Zhang (383859), Hongjing Lin (17812382), Xiaohong Zhang (32960), Gwanyong Lim (17812379), Si Qin (3627863)   +5 more
core  

Construction of circular RNA‐based competing endogenous RNA network in colon cancer

Precision Medical Sciences
Circular RNAs (CircRNAs) are now under discussion as novel promising biomarkers for patients with various tumors. Our study aimed to identify circRNAs related to the progression of colon cancer and to further investigate their roles in the development of
Zhengyu Gu, Weiyi Wu, Jinnan Lu, Jun Shen   +3 more
doaj   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Additional file 5 of Comprehensive analysis of differential immunocyte infiltration and the potential ceRNA networks during epicardial adipose tissue development in congenital heart disease

, 2020
Additional file 5: Table S5.
Wanting Shi (6332579), Xun Ma (737876), Wenlei Li (6526877), Rongjun Zou (6332564), Xinxin Chen (2031439), Weidan Chen (8132484), Li Ma (46633), Minghui Zou (209015)   +7 more
core   +1 more source

Long noncoding RNA AFAP1-AS1 acts as a competing endogenous RNA of miR-423-5p to facilitate nasopharyngeal carcinoma metastasis through regulating the Rho/Rac pathway [PDF]

, 2018
Background Actin filament-associated protein 1 antisense RNA 1 (AFAP1-AS1), a long noncoding RNA, is significantly highly expressed and associated with metastasis and poor prognosis in many cancers, including nasopharyngeal carcinoma (NPC). In this study,
Hui Wang, Gong, Zhaojian, Wei, Fang, Zhaoyang Zeng, Wang, Yumin, Zeng, Zhaoyang, Li, Yong, Lian, Yu, Yang, Liting, Xiayu Li, Yanyan Tang, Fang Wei, Liao, Qianjin, Yumin Wang, Can Guo, Xiang, Bo, Guiyuan Li, Li, Guiyuan, Yong Li, Fang Xiong, Qianjin Liao, Li, Xiaoling, Wang, Hui, Liting Yang, Guo, Can, Zhou, Ming, Xu Wu, Chen, Xiang, Xiong, Wei, Xiaoling Li, Hao Bo, Ming Zhou, Bo Xiang, Xiang Chen, Tang, Yanyan, Bo, Hao, Wu, Xu, Yu Lian, Wei Xiong, Li, Xiayu, Zhaojian Gong, Xiong, Fang   +41 more
core   +1 more source

Competing endogenous RNA networks in the epithelial to mesenchymal transition in diffuse-type of gastric cancer [PDF]

, 2020
The diffuse-type of gastric cancer is associated with epithelial to mesenchymal transition. Loss of E-cadherin expression is the hallmark of this process and is largely due to the upregulation of the transcription factors ZEB1/2, Snail, Slug, and Twist1 ...
Santoro, Pablo, Gonzalo Carrasco-Avino, Corvalán, Alejandro H., Alejandro H. Corvalan, Landeros Pérez, Natalia, Carrasco Aviño, Gonzalo, Natalia Landeros, Pablo M. Santoro   +7 more
core   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Genome‐Wide and Multi‐Omics Analysis Identified DNA‐Interacting Circular RNA circFOXK2 as MLL1 Regulator for Histone H3K4 Methylation in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Circular RNA circFOXK2 is frequently upregulated in pancreatic ductal adenocarcinoma to promote tumor heterogeneity, growth, and metastasis. Through circRNA‐DNA interaction at different genomic locations, circFOXK2 removes the PPIE inhibitory effects on MLL1 for gene‐activating H3K4 methylation of the oncogenes.
Chi Hin Wong, Jessica Jazmin Peña‐Paladines, Sum Yin Valerie Leung, Ka‐Fai To, Kenneth Siu Ho Chok, Yangchao Chen   +5 more
wiley   +1 more source