Results 121 to 130 of about 238,324 (282)

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

NEAT1_2 functions as a competing endogenous RNA to regulate ATAD2 expression by sponging microRNA-106b-5p in papillary thyroid cancer

, 2018
Nuclear paraspeckle assembly transcript 1 (NEAT1), a long non-coding RNA (lncRNA), is a core structural component of paraspeckles and is essential for paraspeckle formation.
Zhihong Wang, Wenwu Dong, Ping Zhang, Hao Zhang, Ting Zhang, Wei Sun, Jinhao Liu, Yuan Qin, Liang He, Xiabin Lan   +9 more
core   +1 more source

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

Identification and experimental validation of circular RNA-associated ceRNA networks in intrauterine adhesion

Frontiers in Genetics
Intrauterine adhesion (IUA) is characterized by endometrial fibrosis, posing significant risks to women’s reproductive health and fertility. This study aimed to uncover a circRNA-associated ceRNA regulatory network relevant to intrauterine adhesion (IUA),
Yajie Chang, Yajie Chang, Yajie Chang, Rui Xiang, Rui Xiang, Rui Xiang, Qi Guo, Qi Guo, Qi Guo, Jing Li, Jing Li, Jing Li, Xiaolan Li, Xiaolan Li, Xiaolan Li, Zhi Zeng, Zhi Zeng, Zhi Zeng, Jintao Peng, Jintao Peng, Jintao Peng, Xiaoyan Liang, Xiaoyan Liang, Xiaoyan Liang   +23 more
doaj   +1 more source

RNA binding protein-mediated competing endogenous RNA mechanism in cancer

Gene
It is evidently now that long non-coding RNAs (lncRNAs) play vital roles in development of cancer through versatile mechanisms. Of importance, lncRNAs play such a regulatory role often through interacting with their partners, including DNAs, RNAs or proteins.
Jingyu, Zhu, Yin-Yuan, Mo, Wan-Xin, Peng
openaire   +2 more sources

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

Decoding competing endogenous RNA networks for cancer biomarker discovery

Briefings in Bioinformatics, 2019
Abstract Crosstalk between competing endogenous RNAs (ceRNAs) is mediated by shared microRNAs (miRNAs) and plays important roles both in normal physiology and tumorigenesis; thus, it is attractive for systems-level decoding of gene regulation.
Xin Qi, Yuxin Lin, Jiajia Chen, Bairong Shen   +3 more
openaire   +2 more sources

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source

A potential role of extended simple sequence repeats in competing endogenous RNA crosstalk

, 2018
MicroRNA (miRNA)-mediated crosstalk between coding and non-coding RNAs of various types is known as the competing endogenous RNA (ceRNA) concept. Here, we propose that there is a specific variant of the ceRNA language that takes advantage of simple ...
Wlodzimierz J. Krzyzosiak (6913), Edyta Koscianska (82344), Agnieszka Fiszer (5919005), Tomasz M. Witkos (5919002)   +3 more
core   +1 more source

Comprehensive analysis of competing endogenous RNA networks associated with cholangiocarcinoma

Experimental and Therapeutic Medicine, 2019
Cholangiocarcinoma (CCA) is the second most common type of primary malignancy of the liver. Certain long non-coding RNAs (lncRNAs) have been demonstrated to have key roles in tumor pathogenesis by binding to microRNAs (miRNAs). However, the competing endogenous RNA (ceRNA) network of CCA remains to be fully determined.
Fangting, Xu, Yuchong, Zhao, Gang, Qin, Ye, Huan, Longyan, Li, Wei, Gao   +5 more
openaire   +3 more sources