Results 111 to 120 of about 299,250 (314)

A competing endogenous RNA network reveals key lncRNAs associated with sepsis

Molecular Genetics & Genomic Medicine, 2021
Background This study set out to determine key lncRNAs correlated with sepsis via constructing competing endogenous RNA (ceRNA) network. Methods Three septic patients and three healthy controls were recruited to obtain lncRNA profiles in this current ...
Xuan Guo, Yanjun Qin, Lili Wang, Shimin Dong, Yan Yan, Xiaohua Bian, Caiyan Zhao   +6 more
doaj   +1 more source

Integrative Analysis of Long Noncoding RNA (lncRNA), microRNA (miRNA) and mRNA Expression and Construction of a Competing Endogenous RNA (ceRNA) Network in Metastatic Melanoma

Medical Science Monitor, 2019
Worldwide, metastatic melanoma of the skin has an aggressive course with high morbidity and mortality. Therefore, an increased understanding of the pathogenesis of metastatic melanoma has gained increasing attention, including the role of epigenetic ...
Li-Xin Wang, C. Wan, Zheng-bang Dong, Bai Wang, Hong-Ye Liu, Yang Li   +5 more
semanticscholar   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Circular RNAs function as competing endogenous RNAs in multiple types of cancer (Review)

Oncology Letters, 2017
Circular (circ)RNAs, naturally formed endogenous non-coding RNAs, have received extensive attention in recent years due to their special loop structures and specific function. circRNAs are formed with covalently closed continuous loops and are mainly generated by back-splicing processes or lariat introns from exons and/or introns. Usually, circRNAs are
Ji, Qing, Zhang, Chengcheng, Sun, Xiaoting, Li, Qi   +3 more
openaire   +3 more sources

Analysis of circular RNA‑associated competing endogenous RNA network in breast cancer

Oncology Letters, 2020
As the most common type of cancer in female patients, the morbidity and mortality rates of breast cancer (BC) are high, and its incidence is gradually increasing worldwide. However, the underlying molecular and genetic mechanisms involved in the etiopathogenesis of BC remain unclear.
Wang, Xuekang, Dong, Yanhan, Wu, Qiong, Lu, Tong, Wang, Yuanyong, Liu, Wenchao, Liu, Chengyu, Xu, Wenhua   +7 more
openaire   +3 more sources

Image2_Construction of lncRNA-Mediated Competing Endogenous RNA Networks Correlated With T2 Asthma.JPEG [PDF]

, 2022
Background: Precise classification has been reported as a central challenge in the clinical research on diagnosis and prediction of treatment efficacy in asthma.
Zihan Wang (3129810), Yun Pan (285227), Jiawei Xu (394968), Tao Feng (43135), Dong Zhang (73558), Liang Dong (381161), Xinrui Qiao (9179146), Xiaofei Liu (72796), Jintao Zhang (846358), Wenjing Cui (296467)   +9 more
core   +1 more source

EBV miR-BARTs and human lncRNAs: Shifting the balance in competing endogenous RNA networks in EBV-associated gastric cancer.

Biochimica et Biophysica Acta - Molecular Basis of Disease, 2021
Non-coding RNAs (ncRNAs) contribute to the regulation of gene expression. By acting as competing endogenous RNA (ceRNA), long non-coding RNAs (lncRNAs) hijack microRNAs (miRNAs) and inhibit their ability to bind their coding targets.
Keila Torres, Natalia Landeros, Ignacio A Wichmann, Iva Polakovičová, F. Aguayo, A. Corvalán   +5 more
semanticscholar   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

NEAT1_2 functions as a competing endogenous RNA to regulate ATAD2 expression by sponging microRNA-106b-5p in papillary thyroid cancer [PDF]

, 2018
Nuclear paraspeckle assembly transcript 1 (NEAT1), a long non-coding RNA (lncRNA), is a core structural component of paraspeckles and is essential for paraspeckle formation.
Zhihong Wang, Wenwu Dong, Ping Zhang, Hao Zhang, Ting Zhang, Wei Sun, Jinhao Liu, Yuan Qin, Liang He, Xiabin Lan   +9 more
core   +1 more source

Competing Endogenous RNA of Snail and Zeb1 UTR in Therapeutic Resistance of Colorectal Cancer [PDF]

, 2021
The epithelial-mesenchymal transition (EMT) comprises an important biological mechanism not only for cancer progression but also in the therapeutic resistance of cancer cells.
김남희, 육종인, 김현실, 차소영   +3 more
core   +1 more source