Results 111 to 120 of about 238,324 (282)

Image4_A Novel Competing Endogenous RNA Network Associated With the Pathogenesis of Graves’ Ophthalmopathy.TIFF

, 2021
Background: Growing evidence has recently revealed the characteristics of long noncoding (lncRNA)/circular RNA (circRNA)-microRNA (miRNA)-mRNA networks in numerous human diseases. However, a scientific lncRNA/circRNA-miRNA-mRNA network related to Graves’
Ruili Wei (848963), Zifan Yue (11837303), Pei Mou (814158), Sainan Chen (3204084), Fei Tong (1729285)   +4 more
core   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Table8_A Novel Competing Endogenous RNA Network Associated With the Pathogenesis of Graves’ Ophthalmopathy.XLSX

, 2021
Background: Growing evidence has recently revealed the characteristics of long noncoding (lncRNA)/circular RNA (circRNA)-microRNA (miRNA)-mRNA networks in numerous human diseases. However, a scientific lncRNA/circRNA-miRNA-mRNA network related to Graves’
Ruili Wei (848963), Zifan Yue (11837303), Pei Mou (814158), Sainan Chen (3204084), Fei Tong (1729285)   +4 more
core   +1 more source

Review of Computational Prediction of Competing Endogenous RNA

Journal of Proteomics & Bioinformatics, 2019
MicroRNAs (miRNAs) are the gene regulatory molecules that bind to microRNA response elements (MREs) in the 3’ untranslated regions (UTRs) of mRNAs. The repressive activity of miRNA is counteracted by “miRNA sponges” or “competing endogenous RNAs (ceRNAs)” termed because of its competing nature of sequestering miRNA’s effect.
Sherin K, Achuthsankar S. Nair
openaire   +1 more source

Protein Disulfide Isomerase Disassembles TDP‐43/G3BP1 Condensates and Antagonizes TDP‐43 Pathological Aggregates

Advanced Science, EarlyView.
Cytoplasmic aggregation of TDP‐43 is a common pathological feature in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer's disease with TDP‐43 pathology. This study reports that wild‐type PDI slows down phase separation of TDP‐43 through direct interaction with TDP‐43.
Jia‐Qi Liu, Hao Liu, Yu‐Xuan Sun, Yuying Li, Xiangyi Liu, Li‐Qiang Wang, Zhaofei Yang, Qi Fu, Xiaojiao Xu, Jie Chen, Yingshuang Zhang, Jun Zhou, Weidong Le, Mengchao Cui, Yi Liang   +14 more
wiley   +1 more source

Long Noncoding RNA HOTAIR Controls Cell Cycle by Functioning as a Competing Endogenous RNA in Esophageal Squamous Cell Carcinoma

, 2016
Recent studies have shown that long noncoding RNAs (lncRNAs) play pivotal roles in the initiation and progression of cancer, including esophageal squamous cell carcinoma (ESCC).
Wu, Kai, Li, Zhen, Kewei Ren, Lu, Huibin, Zhiqin Li, Han, Xinwei, Kai Wu, Yahua Li, Zongming Li, Zhen Li, Huibin Lu, Xinwei Han, Li, Zhiqin, Li, Yahua, Ren, Kewei, Li, Zongming   +15 more
core   +1 more source

Table3_A Novel Competing Endogenous RNA Network Associated With the Pathogenesis of Graves’ Ophthalmopathy.XLSX

, 2021
Background: Growing evidence has recently revealed the characteristics of long noncoding (lncRNA)/circular RNA (circRNA)-microRNA (miRNA)-mRNA networks in numerous human diseases. However, a scientific lncRNA/circRNA-miRNA-mRNA network related to Graves’
Ruili Wei (848963), Zifan Yue (11837303), Pei Mou (814158), Sainan Chen (3204084), Fei Tong (1729285)   +4 more
core   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Image2_Construction of lncRNA-Mediated Competing Endogenous RNA Networks Correlated With T2 Asthma.JPEG

, 2022
Background: Precise classification has been reported as a central challenge in the clinical research on diagnosis and prediction of treatment efficacy in asthma.
Zihan Wang (3129810), Yun Pan (285227), Jiawei Xu (394968), Tao Feng (43135), Dong Zhang (73558), Liang Dong (381161), Xinrui Qiao (9179146), Xiaofei Liu (72796), Jintao Zhang (846358), Wenjing Cui (296467)   +9 more
core   +1 more source