Results 51 to 60 of about 1,823,262 (282)

Integral Analyses of Competing Endogenous RNA Mechanisms and DNA Methylation Reveal Regulatory Mechanisms in Osteosarcoma

Frontiers in Cell and Developmental Biology, 2021
Background: Osteosarcoma (OS) is the most common primary malignant bone tumour in children and adolescents, with rapid growth, frequent metastasis, and a poor prognosis, but its pathogenesis has not been fully elucidated. Exploring the pathogenesis of OS
Tingrui Wu, Bo Wei, Hao Lin, Boan Zhou, Tao Lin, Qianzheng Liu, Hongxun Sang, Huan Liu, Huan Liu, Wenhua Huang, Wenhua Huang, Wenhua Huang   +11 more
doaj   +1 more source

The Role of Competing Endogenous RNA Network in the Development of Hepatocellular Carcinoma: Potential Therapeutic Targets [PDF]

Frontiers in Cell and Developmental Biology
Tang Z, Li X, Zheng Y, Liu J, Liu C, Li X.   +5 more
exaly   +2 more sources

Endogenous double-stranded RNA [PDF]

, 2021
\ua9 2021 by the authors. Licensee MDPI, Basel, Switzerland. The birth of long non-coding RNAs (lncRNAs) is closely associated with the presence and activation of repetitive elements in the genome.
Shaymaa Sadeq, Andreas Werner, Al-Hashimi S, Surar Al-Hashimi, Sadeq S, Werner A, Cusack CM, Carmen M. Cusack   +7 more
core   +1 more source

Competing Endogenous RNA Regulations in Neurodegenerative Disorders: Current Challenges and Emerging Insights [PDF]

, 2018
The past decade has witnessed exciting breakthroughs that have contributed to the richness and complexity of a burgeoning modern RNA world, and one particular breakthrough—the competing endogenous RNA (ceRNA) hypothesis—has been described as the “Rosetta
Jun Wan, Yifei Cai, Wan, Jun, Cai, Yifei
core   +2 more sources

Canonical and Interior Circular RNAs Function as Competing Endogenous RNAs in Psoriatic Skin [PDF]

International Journal of Molecular Sciences, 2021
(1) Background: Understanding the function of circular RNAs (circRNAs), a class of noncoding RNA, in psoriatic skin can provide important insights into the complex regulation of genes contributing to the pathogenesis of psoriasis. (2) Methods: A novel method was applied to RNA-seq datasets from 93 skin biopsy samples to comprehensively identify ...
Xiaoxin Liu, Jacqueline Frost, Anne Bowcock, Weixiong Zhang   +3 more
openaire   +3 more sources

Role of circular RNA as competing endogenous RNA in ovarian cancer (Review). [PDF]

Int J Mol Med
Circular RNA (circRNA), a type of non‑coding RNA, plays a regulatory role in biological processes. The special loop structure of circRNA makes it highly stable and specific in diseased tissues and cells, especially in tumors. Competing endogenous RNAs (ceRNAs) compete for the binding of microRNA (miRNA) at specific binding sites and thus regulate gene ...
Ye W, Xiang N, Wang Q, Lu Y.
europepmc   +3 more sources

A small RNA response at DNA ends in Drosophila [PDF]

, 2012
Small RNAs have been implicated in numerous cellular processes, including effects on chromatin structure and the repression of transposons. We describe the generation of a small RNA response at DNA ends in Drosophila that is analogous to the recently ...
Förstemann, Klaus, Böttcher, Romy, Michalik, Katharina M.   +2 more
core   +1 more source

Whole transcriptome analysis reveals non-coding RNA's competing endogenous gene pairs as novel form of motifs in serous ovarian cancer [PDF]

, 2022
The non-coding RNA (ncRNA) regulation appears to be associated to the diagnosis and targeted therapy of complex diseases. Motifs of non-coding RNAs and genes in the competing endogenous RNA (ceRNA) network would probably contribute to the accurate ...
Li, Haili, Bai, Huimin, Yang, Shu, Dong, Ming, Lixin Cheng, Kwong-Sak Leung, Yakun Liu, Ye, Xiufeng, Leung, Kwong Sak, Man-Hon Wong, Ming Dong, Haili Li, Xubin Zheng, Zheng, Xubin, Wong, Man Hon, Jing Gao, Liu, Yakun, Gao, Jing, Huimin Bai, Cheng, Lixin, Shu Yang, Xiufeng Ye, Liu, Y, Li, H, Bai, H, Yang, S, Wong, M-H, Zheng, X, Leung, K-S, Ye, X, Gao, J, Dong, M   +31 more
core   +1 more source

An improved in vivo tethering assay with single molecule FISH reveals that a nematode Nanos enhances reporter expression and mRNA stability

, 2021
Robust methods are critical for testing the in vivo regulatory mechanism of RNA binding proteins. Here we report improvement of a protein–mRNA tethering assay to probe the function of an RNA binding protein in its natural context within the C.
Kimble, Judith, Lynch, Tina R., Aoki, Scott T., Doenier, Jonathan, Scott T. Aoki, Jonathan Doenier, Judith Kimble, Tina R. Lynch   +7 more
core   +1 more source

Progress in Competing Endogenous RNA and Cancer

Journal of Cancer Therapy, 2015
The competing endogenous RNA (ceRNA) hypothesis was introduced as a previously unrecognized gene regulatory layer. This is a recently discovered hypothesis about how mRNAs, pseudogene transcripts, long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) regulate post-transcriptional expression by sharing common microRNA response elements (MREs ...
Ting Zhang, Weiguo Huang
openaire   +2 more sources