Results 51 to 60 of about 312,740 (284)

LncRNA H19 regulates PI3K–Akt signal pathway by functioning as a ceRNA and predicts poor prognosis in colorectal cancer: integrative analysis of dysregulated ncRNA-associated ceRNA network

Cancer Cell International, 2019
Background It is becoming increasingly clear that cancers can rarely be ascribed to just one or a few genomic variations. Genes generally do not function alone, but in groups that function as “networks”. This study aimed to develop a competing endogenous
Min-Er Zhong, Yanyu Chen, Guannan Zhang, Lai Xu, Wei Ge, Bin Wu   +5 more
doaj   +1 more source

Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. [PDF]

, 2016
Tissue injury, whether by trauma, surgical intervention, metabolic dysfunction, ischemia, or infection, evokes a complex cellular response (inflammation) that is associated with painful hyperalgesic states.
Guan, Zhonghui, Hellman, Judith, Schumacher, Mark   +2 more
core   +2 more sources

Cancer Stem Cells and Competing Endogenous RNAs

, 2022
Cancer stem cells (CSCs) are one of the cell types that account for cancer heterogeneity. They arrest in the G0 phase and generate non-CSC progeny by self-renewing and pluripotency activity, resulting in tumor recurrence, metastasis, and chemoresistance. One CSC can stimulate tumor relapse and can re-grow a metastatic tumor.
Aria, Hamid, Azizi, Mahdieh, Nazem, Shima, Bahmanyar, Maryam, Moravej, Ali, Pourjafarian, Mohammad Hosein, Pezeshki, Babak, Tavassoli, Alireza, Vakil, Mohammad Kazem, Mansoori, Yaser   +9 more
openaire   +1 more source

Construction of PARPi Resistance-related Competing Endogenous RNA Network

Current Genomics, 2022
Objective: Ovarian cancer is the common gynecological malignancy in women. PARP inhibitors (PARPi) have been approved for ovarian cancer treatment. However, the primary and acquired resistance have limited the application of PARPi. The mechanisms underlying remain to be elucidated.
Kong, Lili, Xu, Jiaqi, Yu, Lijun, Liu, Shuo, Liu, Zongjian, Xiang, Juanjuan   +5 more
openaire   +2 more sources

Construction of circRNA-miRNA-mRNA Network for Exploring Underlying Mechanisms of Lubrication Disorder

Frontiers in Cell and Developmental Biology, 2021
Lubrication disorder is a common health issue that manifests as insufficient sexual arousal at the beginning of sex. It often causes physical and psychological distress.
Shengnan Cong, Jinlong Li, Jingjing Zhang, Jingyi Feng, Aixia Zhang, Aixia Zhang, Lianjun Pan, Jiehua Ma   +7 more
doaj   +1 more source

Kinetic modelling of competition and depletion of shared miRNAs by competing endogenous RNAs

, 2018
Non-conding RNAs play a key role in the post-transcriptional regulation of mRNA translation and turnover in eukaryotes. miRNAs, in particular, interact with their target RNAs through protein-mediated, sequence-specific binding, giving rise to extended ...
A Arvey, A Baccarini, A Fatica, A Franks, A Helwak, A Joshi, A Loinger, A Martirosyan, A Martirosyan, A Nadal, A Raveh, A Re, A Riba, A Sanchez, A Sanchez-Mejias, AD Bosson, AK Leung, AM Gurtan, AS Flynt, B Du, B Obermayer, C Bosia, C Bosia, C Bosia, CW Hsu, D Baek, D Kim, DP Bartel, DP Bartel, DP Bartel, DT Gillespie, E Anastasiadou, E Berezikov, E Koller, E Levine, E Levine, FA Karreth, G Tkacik, H Liang, H Teimouri, I Alvarez-Garcia, I Bose, I Legnini, J Breda, J Das, J Fiorentino, J Kwon, J Noorbakhsh, J Tsang, JM Franco-Zorrilla, JM Schmiedel, L López-Maury, L Salmena, L Tsimring, M Chekulaeva, M Figliuzzi, M Figliuzzi, M Gerstein, M Jens, M Klein, M Mauri, M Nitzan, M Osella, M Osella, M Samoilov, MA Gibson, MA Valencia-Sanchez, MS Ebert, MS Ebert, NG Kampen Van, P Flondor, P Mehta, P Sumazin, PB Detwiler, PS Swain, R Denzler, R Denzler, RC Brewster, RC Friedman, RI Gregory, S Djuranovic, S Grigolon, S Guil, S Jonas, S Mukherji, S Pitchiaya, S Sass, S Wang, SD Chandradoss, TB Hansen, TR Cech, U Ala, U Alon, V Siciliano, X Lai, X Wang, X Yuan, Y Liang, Y Shimoni, Y Tay, Y Tay, Y Yuan   +101 more
core   +2 more sources

Innate immune system activation in zebrafish and cellular models of Diamond Blackfan Anemia. [PDF]

, 2018
Deficiency of ribosomal proteins (RPs) leads to Diamond Blackfan Anemia (DBA) associated with anemia, congenital defects, and cancer. While p53 activation is responsible for many features of DBA, the role of immune system is less defined.
Bibikova, Elena, Danilova, Nadia, Lin, Shuo, Sakamoto, Kathleen M, Wilkes, Mark, Youn, Min-Young   +5 more
core   +2 more sources

Interferon-alpha competing endogenous RNA network antagonizes microRNA-1270 [PDF]

Cellular and Molecular Life Sciences, 2015
A new form of circuitry for gene regulation has been identified in which RNAs can crosstalk by competing for shared microRNAs (miRNAs). Such competing endogenous RNAs (ceRNAs) form a network via shared miRNA response elements (MREs) to antagonize miRNA function.
Kimura, Tominori, Jiang, Shiwen, Yoshida, Noriyuki, Sakamoto, Ryou, Nishizawa, Mikio   +4 more
openaire   +2 more sources

Long noncoding RNA SNHG6 mainly functions as a competing endogenous RNA in human tumors

Cancer Cell International, 2020
Increased expression of the small nucleolar RNA host gene 6 (SNHG6) has been reported in different cancers, such as hepatocellular carcinoma, colorectal cancer, and lung cancer.
Hui-shan Wang, Wen Zhang, Han-long Zhu, Quan-peng Li, Lin Miao   +4 more
doaj   +1 more source

Direct activation of RNA polymerase III transcription by c-Myc

, 2003
The proto-oncogene product c-Myc has a direct role in both metazoan cell growth and division. RNA polymerase III (pol III) is involved in the generation of transfer RNA and 5S ribosomal RNA, and these molecules must be produced in bulk to meet the need ...
Eisenman, R.N., Gomez-Roman, N., Grandori, C,, White, R.J.   +3 more
core   +1 more source