Results 81 to 90 of about 365,100 (332)

circTP63 functions as a ceRNA to promote lung squamous cell carcinoma progression by upregulating FOXM1

Nature Communications, 2019
Circular RNAs are known to regulate cancer. Here, the authors show that the circular RNA circTP63 promotes lung squamous cell carcinoma by competing with endogenous RNA to upregulate FOXM1.
Zhuoan Cheng, Chengtao Yu, Shaohua Cui, Hui Wang, Haojie Jin, Cun Wang, Botai Li, Meilin Qin, Chen Yang, Jia He, Qiaozhu Zuo, Siying Wang, Jun Liu, Weidong Ye, Yuanyuan Lv, Fangyu Zhao, Ming Yao, Liyan Jiang, Wenxin Qin   +18 more
doaj   +1 more source

MicroRNA and circular RNA profiling in the deposited fat tissue of Sunite sheep

Frontiers in Veterinary Science, 2022
As the most typical deposited fat, tail fat is an important energy reservoir for sheep adapted to harsh environments and plays an important role as a raw material in daily life.
Xige He, Rihan Wu, Yueying Yun, Yueying Yun, Xia Qin, Yajuan Huang, Lu Chen, Yunfei Han, Jindi Wu, Lina Sha, Gerelt Borjigin   +10 more
doaj   +1 more source

A stable mode of bookmarking by TBP recruits RNA polymerase II to mitotic chromosomes. [PDF]

, 2018
Maintenance of transcription programs is challenged during mitosis when chromatin becomes condensed and transcription is silenced. How do the daughter cells re-establish the original transcription program?
An, Luye, Bhargava-Shah, Aarohi, Darzacq, Xavier, Teves, Sheila S, Tjian, Robert, Xie, Liangqi   +5 more
core  

MicroR159 regulation of most conserved targets in Arabidopsis has negligible phenotypic effects [PDF]

, 2016
BACKGROUND A current challenge of microRNA (miRNA) research is the identification of biologically relevant miRNA:target gene relationships. In plants, high miRNA:target gene complementarity has enabled accurate target predictions, and slicing of target ...
Allen, Robert S, Alonso-Peral, Maria M, Gubler, Frank, Li, Junyan, Millar, Anthony A, White, Rosemary G   +5 more
core   +1 more source

CircUBAP2-mediated competing endogenous RNA network modulates tumorigenesis in pancreatic adenocarcinoma

Aging, 2019
We investigated the role of the competing endogenous RNA (ceRNA) network in the development and progression of pancreatic adenocarcinoma (PAAD). We analyzed the expression profiles of PAAD and normal pancreatic tissues from multiple GEO databases and ...
R. Zhao, J. Ni, Si Lu, Sujing Jiang, Liangkun You, Hao Liu, J. Shou, C. Zhai, Wei Zhang, S. Shao, Xinmei Yang, H. Pan, W. Han   +12 more
semanticscholar   +1 more source

circ_0007385 served as competing endogenous RNA for miR‐519d‐3p to suppress malignant behaviors and cisplatin resistance of non‐small cell lung cancer cells

Thoracic Cancer, 2020
Background Circular RNAs (circRNAs) have been closely implicated in competing endogenous RNA (ceRNA) network among human cancers including non‐small cell lung cancer (NSCLC). However, the role of most circRNAs in NSCLC remains to be determined.
Yancheng Ye, Liangcun Zhao, Qingke Li, C. Xi, Yinghong Li, Zhengguo Li   +5 more
semanticscholar   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Construction of competing endogenous RNA interaction networks as prognostic markers in metastatic melanoma [PDF]

, 2021
Zan He, Zijuan Xin, Yongfei Peng, Hua Zhao, Xiangdong Fang   +4 more
openalex   +1 more source