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Emerging Advances of Non-coding RNAs and Competitive Endogenous RNA Regulatory Networks in Asthma [PDF]

Bioengineered, 2021
Asthma is a chronic inflammatory disease characterized by airway remodeling and bronchial hyperresponsiveness. A variety of effector cells and cytokines jointly stimulate the occurrence of inflammatory response in asthma. Although the pathogenesis of asthma is not entirely clear, the possible roles of non-coding RNAs (ncRNAs) have been recently ...
Zhiliang Guo
exaly   +3 more sources

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Long Non-Coding RNAs as Competitive Endogenous RNAs in Osteosarcoma

Molecular Biology, 2020
It was more than twenty years ago that miRNAs were recognized as a new class of RNA, but the understanding of their regulatory role is just beginning to emerge. Furthermore, it was found that the function of miRNAs as "master regulators" can be controlled by other non-coding RNAs (ncRNAs), in particular, long ncRNAs (lncRNAs).
N E, Kushlinskii, M V, Fridman, E A, Braga   +2 more
openaire   +2 more sources

Pseudogenes as Competitive Endogenous RNAs: Testing miRNA Dependency

2021
Pseudogenes may function as competitive endogenous RNAs (ceRNAs), where they regulate the expression of genes by sequestering shared miRNAs. ceRNAs are becoming more extensively identified and studied, and demonstrating the dependence of their effects on miRNA sequestration is critical to establish them as ceRNAs.
Xiaonan, Xu, Florian A, Karreth
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Computational prediction of competitive endogenous RNA

2015 IEEE Biomedical Circuits and Systems Conference (BioCAS), 2015
MicroRNAs (miRNAs) play an important role in the post-transcriptional regulation of gene expression by pairing target messenger RNAs (mRNAs). As the abnormal expression of miRNAs has been implicated in various diseases, there has been many studies on regulating the expression level of miRNA, including “miRNA sponges.” miRNA sponges, which are ...
Seunghyun Park 0001, Soowon Kang, Hyeyoung Min, Sungroh Yoon   +3 more
openaire   +1 more source

Mimicry, deception and competition: The life of competing endogenous RNAs

WIREs RNA, 2019
Since their discovery, small regulatory RNAs (sRNAs) were thought to be regulated exclusively at the transcriptional level. However, accumulating data from recent reports indicate that posttranscriptional signals can also modulate the function and stability of sRNAs.
Marc P, Grüll, Eric, Massé
openaire   +2 more sources

Sp1 is a competitive endogenous RNA of Klf4 during odontoblast differentiation

The International Journal of Biochemistry & Cell Biology, 2017
Our previous studies have demonstrated that KLF4 is a critical transcription factor that promotes the odontoblastic differentiation of dental papilla cells. Klf4 mRNA was found to be regulated by multiple microRNAs (miRNAs). Competitive endogenous RNAs (ceRNAs) are a group of transcripts post-transcriptionally regulating each other by competing for ...
Jie, Zhang, Huan, Liu, Heng, Lin, Shuchen, Li, Huangheng, Tao, Lu, Zhang, Guohua, Yuan, Zhi, Chen   +7 more
openaire   +2 more sources

Construction of a Competitive Endogenous RNA Network Related to Exosomes in Diabetic Retinopathy

Combinatorial Chemistry & High Throughput Screening, 2023
Background: The competing endogenous RNA (ceRNA) network plays an important role in the occurrence and development of a variety of diseases. This study aimed to construct a ceRNA network related to exosomes in diabetic retinopathy (DR). Methods: We explored the Gene Expression Omnibus (GEO) database and then analyzed the RNAs of samples to obtain ...
Tong, Wang, Mao-Yuan, Cheng, Meng-Ya, Shan, Cui-Yao, Tang, Nai-Jia, Pan, Zi-Hui, Xu, Xian-Lun, Tang   +6 more
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Competitive Endogenous RNAs Participate in Benzene Hematotoxicity by Promoting Ferroptosis

SSRN Electronic Journal, 2021
Background: Benzene exposure leads to hematotoxicity, but we still lack sensitive biomarkers for its monitoring and prevention owing to the complex mechanisms. We previously constructed a competitive endogenous RNA(ceRNA) regulatory network (Lnc-TC-miR-142-5p-CUL4B), which may be potential biomarkers for benzene hematotoxicity, and further explored the
Jing Ren, Jingyu Wang, Xiaoli Guo, Wei Zhang, Yujiao Chen, Ai Gao   +5 more
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Pseudogenes as Competitive Endogenous RNAs: Target Prediction and Validation

2014
Pseudogenes may regulate expression of their parental genes as well as other protein-coding genes through various mechanisms. One such mechanism is the ability to act as competitive endogenous RNA (ceRNA) and participate in microRNA-mediated cross-regulation.
Karreth, Florian A., Ala, Ugo, Provero, Paolo, Pandolfi, Pier Paolo   +3 more
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The development and controversy of competitive endogenous RNA hypothesis in non-coding genes

Molecular and Cellular Biochemistry, 2020
As a momentous post-transcriptional regulator, microRNAs (miRNAs) are attracting more and more attention. The classical miRNAs regulated mechanism shows it binds to the targets' 3'UTR thus play the role in post-transcription. Meanwhile, single miRNA can target multiple genes, so those should compete to bind that miRNA.
Weimin Lin, Hongcheng Liu, Yonghang Tang, Yuchen Wei, Wei Wei, Lifan Zhang, Jie Chen   +6 more
openaire   +2 more sources