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The development and controversy of competitive endogenous RNA hypothesis in non-coding genes
Molecular and Cellular Biochemistry, 2020As a momentous post-transcriptional regulator, microRNAs (miRNAs) are attracting more and more attention. The classical miRNAs regulated mechanism shows it binds to the targets' 3'UTR thus play the role in post-transcription. Meanwhile, single miRNA can target multiple genes, so those should compete to bind that miRNA.
Weimin Lin +6 more
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Competitive endogenous RNA networks: Decoding the role of long non‐coding RNAs and circular RNAs in colorectal cancer chemoresistance [PDF]
Journal of Cellular and Molecular MedicineAli Khalafizadeh +2 more
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Competitive endogenous RNA network: potential implication for systemic lupus erythematosus
Expert Opinion on Therapeutic Targets, 2017Competitive endogenous RNA (ceRNA) hypothesis proposes that RNA transcripts, both coding and non-coding, crosstalk with and coregulate each other using microRNA response elements (MREs). CeRNA analysis tremendously expands functional information of coding and non-coding RNAs.
Lian-Ju Li, Sha-Sha Tao, Rui-Xue Leng
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The BRAF Pseudogene Is a Proto-Oncogenic Competitive Endogenous RNA
Blood, 2014Abstract Non-coding RNAs have long been viewed as non-functional genomic relicts of evolution, but recetn findings have implicated their importance in physiology and disease. Recently, in vitro experiments demonstrated that the pseudogenes of PTEN and KRAS operate as natural miRNA decoys (competitive endogenous RNAs or ceRNAs) that ...
Florian Karreth +5 more
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Clinical and Experimental Medicine, 2020
To investigate lncRNAs acting as competing endogenous RNAs (ceRNAs) involved in oncogenesis and progression of HCC. Different expressed lncRNAs, microRNAs, and mRNAs (DElncRNAs, DEmiRNAs, DEmRNAs), downloaded from The Cancer Genome Atlas (TCGA) database, were identified by edgeR package.
Lili Qu +8 more
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To investigate lncRNAs acting as competing endogenous RNAs (ceRNAs) involved in oncogenesis and progression of HCC. Different expressed lncRNAs, microRNAs, and mRNAs (DElncRNAs, DEmiRNAs, DEmRNAs), downloaded from The Cancer Genome Atlas (TCGA) database, were identified by edgeR package.
Lili Qu +8 more
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Combinatorial Chemistry & High Throughput Screening, 2020
Background: Neonatal sepsis is a serious and difficult-to-diagnose systemic infectious disease occurring during the neonatal period. Objective: This study aimed to identify potential biomarkers of neonatal sepsis and explore its underlying mechanisms.
Ling, Liu +3 more
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Background: Neonatal sepsis is a serious and difficult-to-diagnose systemic infectious disease occurring during the neonatal period. Objective: This study aimed to identify potential biomarkers of neonatal sepsis and explore its underlying mechanisms.
Ling, Liu +3 more
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Immune-Related Hub Genes and the Competitive Endogenous RNA Network in Alzheimer’s Disease
Journal of Alzheimer’s Disease, 2020Background: The pathogenesis of Alzheimer’s disease (AD) involves various immune-related phenomena; however, the mechanisms underlying these immune phenomena and the potential hub genes involved therein are unclear.
Hui, Xu, Jianping, Jia
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Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2020
Long noncoding RNAs (lncRNAs) have gain increasing attention in lung adenocarcinoma. In this study, we aimed at constructing and analyzing the lncRNAs and the related proteins based competitive endogenous RNA (ceRNA) network.RNA expression data of lung adenocarcinoma were extracted from the TCGA database.
Chang, Gu +6 more
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Long noncoding RNAs (lncRNAs) have gain increasing attention in lung adenocarcinoma. In this study, we aimed at constructing and analyzing the lncRNAs and the related proteins based competitive endogenous RNA (ceRNA) network.RNA expression data of lung adenocarcinoma were extracted from the TCGA database.
Chang, Gu +6 more
openaire +2 more sources
2019
MicroRNAs (miRNAs) are fine-tuners of gene expression and contribute to the regulation of most, if not all, biological processes in eukaryotes by targeting both coding and noncoding RNAs. Typically, miRNAs repress numerous target transcripts and most target RNAs harbor binding sites for multiple miRNA families. It was recently proposed that transcripts
openaire +2 more sources
MicroRNAs (miRNAs) are fine-tuners of gene expression and contribute to the regulation of most, if not all, biological processes in eukaryotes by targeting both coding and noncoding RNAs. Typically, miRNAs repress numerous target transcripts and most target RNAs harbor binding sites for multiple miRNA families. It was recently proposed that transcripts
openaire +2 more sources