Results 81 to 90 of about 3,038,737 (399)

Long-term safety and efficacy of the combination of belimumab and rituximab in the treatment of severe and refractory SLE: a preliminary report

open access: yesLupus Science and Medicine
Objective Combination therapy with rituximab and belimumab is a novel treatment strategy for severe SLE and lupus nephritis. Phase II studies have shown promising results, although long-term data are currently lacking.
Tineke Kraaij   +11 more
doaj   +1 more source

Nephritic Factors: An Overview of Classification, Diagnostic Tools and Clinical Associations

open access: yesFrontiers in Immunology, 2019
Nephritic factors comprise a heterogeneous group of autoantibodies against neoepitopes generated in the C3 and C5 convertases of the complement system, causing its dysregulation.
Fernando Corvillo   +11 more
doaj   +1 more source

Complement Factor H Family Proteins Modulate Monocyte and Neutrophil Granulocyte Functions

open access: yesFrontiers in Immunology, 2021
Besides being a key effector arm of innate immunity, a plethora of non-canonical functions of complement has recently been emerging. Factor H (FH), the main regulator of the alternative pathway of complement activation, has been reported to bind to ...
Éva Kárpáti   +7 more
doaj   +1 more source

Simple loops on 2-bridge spheres in 2-bridge link complements

open access: yes, 2011
The purpose of this note is to announce complete answers to the following questions. (1) For an essential simple loop on a 2-bridge sphere in a 2-bridge link complement, when is it null-homotopic in the link complement?
Lee, Donghi, Sakuma, Makoto
core   +1 more source

Coxeter transformation groups and reflection arrangements in smooth manifolds [PDF]

open access: yes, 2015
Artin groups are a natural generalization of braid groups and are well-understood in certain cases. Artin groups are closely related to Coxeter groups.
Das, Ronno, Deshpande, Priyavrat
core   +1 more source

The intersection of complemented submodules is not complemented

open access: yes, 2023
We show by (counter)example that the intersection of complemented submodules in a Hilbert $C^*$-module is not necessarily complemented, answering an open question from [MR].
Dungen, Koen van den   +2 more
openaire   +2 more sources

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

open access: yesMolecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever   +1 more
wiley   +1 more source

Haemolytic uremic syndrome: diagnosis and management [version 1; peer review: 3 approved]

open access: yesF1000Research, 2019
The thrombotic microangiopathies (TMAs) are a group of diseases characterised by microangiopathic haemolysis, thrombocytopenia, and thrombus formation leading to tissue injury.
Neil S. Sheerin, Emily Glover
doaj   +1 more source

Immunological features of patients affected by Barraquer-Simons syndrome

open access: yesOrphanet Journal of Rare Diseases, 2020
Background C3 hypocomplementemia and the presence of C3 nephritic factor (C3NeF), an autoantibody causing complement system over-activation, are common features among most patients affected by Barraquer-Simons syndrome (BSS), an acquired form of partial ...
Fernando Corvillo   +13 more
doaj   +1 more source

The differential ability of human IgG1 and IgG4 to activate complement is determined by the COOH-terminal sequence of the CH2 domain. [PDF]

open access: yes, 1991
Using domain switch chimeric antibodies, we confirm the important role of CH2 in complement activation. In addition, we demonstrate that the structures responsible for the differential ability of human IgG1 and IgG4 to activate complement are located at ...
Canfield, SM, Morrison, SL, Tao, MH
core  

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