Results 21 to 30 of about 46,139 (228)

Smallpox Inhibitor of Complement Enzymes (SPICE): Dissecting Functional Sites and Abrogating Activity [PDF]

The Journal of Immunology, 2009
Abstract Although smallpox was eradicated as a global illness more than 30 years ago, variola virus and other related pathogenic poxviruses, such as monkeypox, remain potential bioterrorist weapons or could re-emerge as natural infections. Poxviruses express virulence factors that down-modulate the host’s immune system.
M Kathryn, Liszewski, Marilyn K, Leung, Richard, Hauhart, Celia J, Fang, Paula, Bertram, John P, Atkinson   +5 more
openaire   +2 more sources

Smallpox Inhibitor of Complement Enzymes (SPICE): Regulation of Complement Activation on Cells and Mechanism of Its Cellular Attachment [PDF]

The Journal of Immunology, 2008
Abstract Despite eradication of smallpox three decades ago, public health concerns remain due to its potential use as a bioterrorist weapon. Smallpox and other orthopoxviruses express virulence factors that inhibit the host’s complement system.
M Kathryn, Liszewski, Paula, Bertram, Marilyn K, Leung, Richard, Hauhart, Lijuan, Zhang, John P, Atkinson   +5 more
openaire   +2 more sources

Complement activation and regulation in preeclampsia and hemolysis, elevated liver enzymes, and low platelet count syndrome [PDF]

American Journal of Obstetrics and Gynecology, 2022
The complement system is critical to human health owing to its central role in host defense and innate immunity. During pregnancy, the complement system must be appropriately regulated to allow for immunologic tolerance to the developing fetus and placenta.
Richard M, Burwick, Bruce B, Feinberg
openaire   +2 more sources

Citrullination in Rheumatoid Arthritis—A Process Promoted by Neutrophil Lysis?

Rambam Maimonides Medical Journal, 2016
Anti-citrullinated protein antibodies (ACPAs) are highly specific serologic markers for rheumatoid arthritis (RA) and can pre-date clinical disease onset by up to 10 years, also predicting erosive disease.
Tal Gazitt, Christian Lood, Keith B. Elkon   +2 more
doaj   +1 more source

The role of the Lys628 (192) residue of the complement protease, C1s, in interacting with peptide and protein substrates

Frontiers in Immunology, 2014
The C1s protease of the classical complement pathway propagates the initial activation of this pathway of the system by cleaving and thereby activating the C4 and C2 complement components.
Lakshmi Carmel Wijeyewickrema, Renee Charlene Duncan, Robert Neil Pike   +2 more
doaj   +1 more source

Acute-phase proteins: As diagnostic tool

Journal of Pharmacy and Bioallied Sciences, 2011
The varied reactions of the host to infection, inflammation, or trauma are collectively known as the acute-phase response and encompass a wide range of pathophysiological responses such as pyrexia, leukocytosis, hormone alterations, and muscle protein ...
Sachin Jain, Vidhi Gautam, Sania Naseem
doaj   +1 more source

Profiling gene expression induced by protease-activated receptor 2 (PAR2) activation in human kidney cells.

PLoS ONE, 2010
Protease-Activated Receptor-2 (PAR2) has been implicated through genetic knockout mice with cytokine regulation and arthritis development. Many studies have associated PAR2 with inflammatory conditions (arthritis, airways inflammation, IBD) and key ...
Jacky Y Suen, Brooke Gardiner, Sean Grimmond, David P Fairlie   +3 more
doaj   +1 more source

Quantification of Porcine Complement Activation Fragment C3a by a Neoepitope-Based Enzyme-Linked Immunosorbent Assay

, 2021
Enzyme-linked immunosorbent assay (ELISA) enables fast and simple quantification of analytes in the pico- to nanogram range in complex samples. Here, we describe an ELISA for the detection of porcine C3a as a marker for complement activation. Antibody specificity is critical for a robust assay.
Nilsson, Per H., Pettersen, Kristin, Oppermann, Martin, Skjeflo, Espen W., Fure, Hilde, Christiansen, Dorte, Mollnes, Tom Eirik, Roumenina, Lubka T.   +7 more
openaire   +6 more sources

Non-enzymic activation of the covalent binding reaction of the complement protein C3 [PDF]

Biochemical Journal, 1983
The covalent binding of [3H]glycerol to C3 by the transfer of the acyl group of the internal thioester of C3 to the hydroxy group of glycerol can be activated either proteolytically by trypsin or by various chaotropes and denaturants. The activation of binding by trypsin or KBr showed similar dependence on the concentration of glycerol, indicating a ...
openaire   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source