Results 111 to 120 of about 4,342,004 (341)

Restricted Complement Activation by Escherichia Coli with the K-1 Capsular Serotype: A Possible Role in Pathogenicity [PDF]

, 1978
Paul Stevens, Shena N-Y. Huang, William D. Welch, Lowell S. Young   +3 more
openalex   +1 more source

S267: PROPERDIN-BLOCKING ANTIBODIES ATTENUATE COMPLEMENT ALTERNATIVE PATHWAY ACTIVATION TRIGGERED BY CELL-FREE HEME IN SICKLE CELL DISEASE MODELS

, 2022
Thiago Trovati Maciel, Roxanne Cofiell, Caroline Carvalho, Slimane Allali, Rachel Rignault, A. Bennet, Yang Dai, Paul P. Tamburini, Christoph Gasteyger, Olivier Hermine, S. K. Kim   +10 more
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Complement Activation in Nephrotic Glomerular Diseases

Biomedicines
The nephrotic syndrome holds significant clinical importance and is characterized by a substantial protein loss in the urine. Damage to the glomerular basement membrane or podocytes frequently underlies renal protein loss.
Dominik Nell, Robert Wolf, Przemyslaw Marek Podgorny, Tobias Kuschnereit, Rieke Kuschnereit, Thomas Dabers, Sylvia Stracke, Tilman Schmidt   +7 more
doaj   +1 more source

Human brain trauma severity is associated with lectin complement pathway activation [PDF]

, 2018
Daiana De Blasio, Stefano Fumagalli, Franca Orsini, Laura Neglia, Carlo Perego, Fabrizio Ortolano, Elisa R. Zanier, Edoardo Picetti, Marco Locatelli, Nino Stocchetti, Luca Longhi, Peter Garred, Maria Grazia De Simoni   +12 more
openalex   +1 more source

Complement System Part I – Molecular Mechanisms of Activation and Regulation

Frontiers in Immunology, 2015
Complement is a complex innate immune surveillance system, playing a key role in defense against pathogens and in host homeostasis. The complement system is initiated by conformational changes in recognition molecular complexes upon sensing danger ...
N. Merle, S. Church, V. Frémeaux-Bacchi, L. Roumenina   +3 more
semanticscholar   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Role of the complement system in the tumor microenvironment

Cancer Cell International, 2019
The complement system has traditionally been considered a component of innate immunity against invading pathogens and “nonself” cells. Recent studies have demonstrated the immunoregulatory functions of complement activation in the tumor microenvironment (
Ronghua Zhang, Qiaofei Liu, Tong Li, Quan Liao, Yupei Zhao   +4 more
doaj   +1 more source

Modulation of complement activation by pentraxin-3 in prostate cancer [PDF]

, 2020
Giovanni Stallone, Giuseppe Stefano Netti, Luigi Cormio, Giuseppe Castellano, Barbara Infante, Paola Pontrelli, Chiara Divella, Oscar Selvaggio, Federica Spadaccino, Elena Ranieri, Francesca Sanguedolce, Antonio Pennella, Loreto Gesualdo, Giuseppe Carrieri, Giuseppe Grandaliano   +14 more
openalex   +1 more source