Results 111 to 120 of about 4,621,354 (401)

VERSATILITY OF THE COMPLEMENT SYSTEM IN NEUROINFLAMMATION, NEURODEGENERATION AND BRAIN HOMEOSTASIS

Frontiers in Cellular Neuroscience, 2014
The immune response after brain injury is highly complex and involves both local and systemic events at the cellular and molecular level. It is associated to a dramatic over-activation of enzyme systems, the expression of proinflammatory genes and the ...
Franca eOrsini, Daiana eDe Blasio, Daiana eDe Blasio, Rosalia eZangari, Rosalia eZangari, Elisa R. Zanier, Maria-Grazia eDe Simoni   +6 more
doaj   +1 more source

Complement Overactivation and Consumption Predicts In-Hospital Mortality in SARS-CoV-2 Infection

Frontiers in Immunology, 2021
ObjectivesUncontrolled thromboinflammation plays an important role in the pathogenesis of coronavirus disease (COVID-19) caused by SARS-CoV-2 virus. Complement was implicated as key contributor to this process, therefore we hypothesized that markers of ...
György Sinkovits, Blanka Mező, Blanka Mező, Marienn Réti, Veronika Müller, Zsolt Iványi, János Gál, László Gopcsa, Péter Reményi, Beáta Szathmáry, Botond Lakatos, János Szlávik, Ilona Bobek, Zita Z. Prohászka, Zsolt Förhécz, Dorottya Csuka, Lisa Hurler, Erika Kajdácsi, László Cervenak, Petra Kiszel, Tamás Masszi, István Vályi-Nagy, István Vályi-Nagy, Zoltán Prohászka, Zoltán Prohászka   +24 more
doaj   +1 more source

Structural features of human immunoglobulin G that determine isotype-specific differences in complement activation. [PDF]

, 1993
Although very similar in sequence, the four subclasses of human immunoglobulin G (IgG) differ markedly in their ability to activate complement. Glu318-Lys320-Lys322 has been identified as a key binding motif for the first component of complement, C1q ...
Morrison, SL, Smith, RI, Tao, MH
core  

Combinatorial functions of two chimeric antibodies directed to human CD4 and one directed to the a-chain of the human interleukin-2 receptor [PDF]

, 1992
The general feasibility of chimerization of monoclonal antibodies (mAbs) has already been shown for a large number of them. In order to evaluate in vitro parameters relevant to immunosuppressive therapy, we have chimerized and synthesized two anti-CD4 ...
Flieger, Dimitri, Kaluzab, Brigitte, Lenz, Helmut, Reiter, Christian, Rieber, Ernst Peter, Riethmüller, Gert, Scheuer, Werner, Schwirzke, Marina, Weidle, Ulrich H., Weiss, Elisabeth H., Weissenhorn, Winfried   +10 more
core   +1 more source

C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation

Nature Communications, 2016
Complement C1q is the activator of the classical pathway. However, it is now recognized that C1q can exert functions unrelated to complement activation.
R. Bulla, C. Tripodo, Damiano Rami, G. Ling, C. Agostinis, C. Guarnotta, S. Zorzet, P. Durigutto, M. Botto, Francesco Saverio Tedesco   +9 more
semanticscholar   +1 more source

Complement activation by recombinant adenoviruses [PDF]

Gene Therapy, 2001
Recombinant adenoviruses are currently the most important vector system in gene therapy. Adenoviruses frequently cause upper respiratory tract infections in humans and anti-adenoviral antibodies are found in 35-70% of the population. Therefore in the majority of potential patients receiving adenoviral gene therapy, the contact of virus particles and ...
T Müller, Hartmut H.-J. Schmidt, S Boeckh-Herwig, G Cichon, E Wehnes, R Burger, P Pring-Akerblom   +6 more
openaire   +2 more sources

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Pathological significance of urinary complement activation in diabetic nephropathy: A full view from the development of the disease

Journal of Diabetes Investigation, 2019
Aims/Introduction The aim of the present study was to obtain a full view of the changes of urinary complement activation products in the development of diabetic nephropathy and explore their possible significance in the disease process.
Jing‐Min Zheng, Zuan‐Hong Jiang, De‐Jun Chen, Sa‐Sa Wang, Wen‐Jin Zhao, Li‐Juan Li   +5 more
doaj   +1 more source

Multi-activity Influence and Intervention [PDF]

arXiv, 2021
Using a general network model with multiple activities, we analyse a planner's welfare maximising interventions taking into account within-activity network spillovers and cross-activity interdependence. We show that the direction of the optimal intervention, under sufficiently large budgets, critically depends on the spectral properties of two matrices:
arxiv  

Incomplete inhibition by eculizumab: mechanistic evidence for residual C5 activity during strong complement activation.

Blood, 2017
Eculizumab inhibits the terminal, lytic pathway of complement by blocking the activation of the complement protein C5 and shows remarkable clinical benefits in certain complement-mediated diseases.
M. Harder, Nadine Kuhn, H. Schrezenmeier, B. Höchsmann, I. von Zabern, C. Weinstock, T. Simmet, Daniel Ricklin, John D Lambris, A. Skerra, M. Anliker, C. Schmidt   +11 more
semanticscholar   +1 more source