Results 141 to 150 of about 4,342,004 (341)

Persistent complement dysregulation with signs of thromboinflammation in active Long Covid

Science
Long Covid is a debilitating condition of unknown etiology. We performed multimodal proteomics analyses of blood serum from COVID-19 patients followed up to 12 months after confirmed severe acute respiratory syndrome coronavirus 2 infection. Analysis of >
Carlo Cervia-Hasler, S. Brüningk, Tobias Hoch, Bowen Fan, Giulia Muzio, Ryan C. Thompson, Laura Ceglarek, Roman Meledin, Patrick Westermann, M. Emmenegger, Patrick Taeschler, Yves Zurbuchen, Michele Pons, D. Menges, T. Ballouz, Sara Cervia-Hasler, Sarah Adamo, M. Merad, Alexander W. Charney, M. Puhan, P. Brodin, J. Nilsson, Adriano Aguzzi, M. E. Raeber, Christoph B. Messner, N. Beckmann, Karsten M. Borgwardt, O. Boyman   +27 more
semanticscholar   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Storage of Transfusion Platelet Concentrates Is Associated with Complement Activation and Reduced Ability of Platelets to Respond to Protease-Activated Receptor-1 and Thromboxane A2 Receptor [PDF]

Linnéa Andersson, Dick J. Sjöström, Huy Quang Quach, Kim Hägerström, Lisa Hurler, Erika Kajdácsi, László Cervenak, Zoltán Prohászka, Erik J. M. Toonen, Camilla Mohlin, Tom Eirik Mollnes, Per Sandgren, Ivar Tjernberg, Per H. Nilsson   +13 more
openalex   +1 more source

Effect of sodium nitroprusside on complement activation induced by cardiopulmonary bypass: A clinical and experimental study [PDF]

, 1996
Marie-Christine Seghaye, Jean Duchateau, Ralph Grabitz, Thibault Wolffbb, Christiane Marcus, W. Engelhardt, H Hörnchen, Bruno J. Messmer, Goetz von Bernuth   +8 more
openalex   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Complement activation in patients with COVID-19: A novel therapeutic target

Journal of Allergy and Clinical Immunology, 2020
M. Cugno, P. Meroni, R. Gualtierotti, S. Griffini, E. Grovetti, A. Torri, M. Panigada, S. Aliberti, F. Blasi, F. Tedesco, F. Peyvandi   +10 more
semanticscholar   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Role of IgM and angiotensin II Type I receptor autoantibodies in local complement activation in placental ischemia-induced hypertension in the rat

, 2016
Jean F. Regal, Megan E Strehlke, Jenna M Peterson, Cameron R. Wing, Jordan E. Parker, Noel Fernando Nieto, Lynne Bemis, Jeffrey S. Gilbert, Sherry D. Fleming   +8 more
openalex   +1 more source