Results 151 to 160 of about 651,857 (304)

Molecular determinants of STEC-HUS: from complement activation to microvascular thrombosis. [PDF]

Front Immunol
Santarsiero D, Galbusera M, Gastoldi S, Bresin E, Piras R, Alberti M, Vivarelli M, Prandini S, Conti S, Zotta F, Schubart A, Benigni A, Remuzzi G, Noris M, Aiello S.   +14 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Yersinia enterocolitica O:3 Outer Membrane Vesicles as a Platform for Complement Activation. [PDF]

J Extracell Vesicles
Battaglino C, Bodnaruk I, Czyszczoń P, Skurnik M, Filip-Psurska B, Jarych D, Maciejewska A, Gadzinowski M, Malik K, Potocka I, Migdał P, Kruszakin R, Cedzyński M, Kasperkiewicz K, Lukasiewicz J, Świerzko AS.   +15 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Complement activation in secondary thrombotic microangiopathies. [PDF]

Nephrol Dial Transplant
Morelle J, Caravaca-Fontan F, Fakhouri F, Frangou E, Bruchfeld A, Floege J, Mirioglu S, Moran SM, Steiger S, Stevens KI, Teng OYK, Aydin S, Java A, Timmermans SAMEG, Kronbichler A.   +14 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Complement Activation as a Predictor of Postoperative Delirium in Elderly Spine Surgery Patients. [PDF]

Int J Mol Sci
Vogelgesang A, Wolf H, Strack S, Flöel A, Schroeder HWS, Müller J, Müller JU, Fleischmann A, Fleischmann R, Pauly D, Ruhnau J.   +10 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Aberrant Complement Activation Is a Prominent Feature of Chronic Inflammatory Demyelinating Polyneuropathy. [PDF]

Neurol Neuroimmunol Neuroinflamm
Stascheit F, Preßler H, Stein K, Pernice HF, Hahn K, Meisel A, Lünemann JD.   +6 more
europepmc   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source