Results 141 to 150 of about 2,294,616 (302)

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Complement Activation in Maternal and Placental Pathology of Preeclampsia. [PDF]

Hypertension
Banadakoppa MT, Chauhan MS, Tacam MJ, Nevins AW, Ruano AH, Ruano SH, Fuson JA, Yallampalli C.   +7 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Investigation of Complement Activation and Cytokine Signatures in AQP4+ NMOSD, MOGAD, and MS. [PDF]

Ann Clin Transl Neurol
Filippatou AG, Dominguez-Penuela S, Acero-Garces D, Gakis G, Smith MD, Resto Y, Reyes-Mantilla M, Chen H, Hernandez I, Said Y, Salazar-Camelo A, Huynh C, Tassoni A, Yednock T, Artis R, Andrews-Zwilling Y, Newsome SD, Saidha S, Bhargava P, Mowry EM, Fitzgerald KC, Calabresi PA, Pardo CA, Sotirchos ES.   +23 more
europepmc   +1 more source

補体学入門 : Cold Activation現象の発見から現在の問題点まで(自然科学系)

, 1997
This short review is for beginners in complementology. The complement system is composed of 30 kinds of physiological proteins: 14 serum complement components; 6 serum inhibitors; 4 membrane inhibitors; and 6 complement receptors on the cellular membrane.
北村, 肇, Kitamura, Hajime
core  

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Complement Activation by Post-Translationally Modified Proteins: Links to Chronic Inflammation and Autoimmunity. [PDF]

Immunol Rev
van Greevenbroek MMJ, Trouw LA.
europepmc   +1 more source

Usefulness and analytical performances of complement multiplex assay for measuring complement biomarkers in plasma

International audienceIntroduction. The complement system is involved in numerous diseases, through diverse mechanisms and degree of activation. With the emergence of complement targeting therapeutic, simple and accessible tools to evaluate the extent of
Courbebaisse, Marie, Duval, Anna, Vieira-Martins, Paula, Chauvet, Sophie, Grunenwald, Anne, Peliconi, Julie, Frémeaux-Bacchi, Véronique, Dragon-Durey, Marie-Agnès, Meuleman, Marie-Sophie, Friedlander, Gérard, Revel, Margot, Rezola Artero, Mikel, Dermani, Mohamed, Roumenina, Lubka, Parfait, Béatrice, Lebeaux, David   +15 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source