Results 171 to 180 of about 2,294,616 (302)

Clinical Value of Kidney Immunodeposits and Urinary Complement Activation Fragments in IgAN. [PDF]

Kidney Int Rep
Royal V, Caliskan Y, Laurin LP, Bonnefoy A, Merlen C, Lentine KL, Troyanov S, CureGN Collaborators7, CureGN Collaborators.   +8 more
europepmc   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

The black fly salivary protein Simukunin inhibits complement activation through the lectin pathway protease MASP-2. [PDF]

J Biol Chem
Jung MD, Ring ME, Bonilla BG, Ganesan S, Valenzuela-Leon PC, Calvo E.   +5 more
europepmc   +1 more source

Complement Activation in Pemphigus

Journal of Investigative Dermatology, 1980
openaire   +2 more sources

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

KIAA1199 aggravates sepsis-induced lung injury by promoting complement activation. [PDF]

Commun Biol
Qin Y, Zhang J, Zhang Y, Ling S, Ren W, Liu L, Jin S, Wang J, Yang X.   +8 more
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Sialic Acids in Kidney Disease: Immune Regulation, Complement Activation and Glomerular Injury. [PDF]

Antioxidants (Basel)
Spennacchio A, Caridi G, Bigatti C, Gaggero G, Mazzocco K, Gambaudo MT, Musso R, Vellone VG, Angeletti A, Kajana X.   +9 more
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Early binding of anti-amyloid antibodies to CAA drives complement activation, inflammation and ARIA in mice. [PDF]

Mol Neurodegener
Bathini P, Schilling S, Rahfeld JU, Holtzman DM, Saido TC, Lemere CA.   +5 more
europepmc   +1 more source