Results 211 to 220 of about 4,342,004 (341)

Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer, Frauke Stascheit, Maximilian Mönch, Paolo Doksani, Carla Dusemund, Meret Herdick, Philipp Mergenthaler, Maike Stein, Amani Suboh, Jutta Schröder‐Braunstein, Guido Wabnitz, Jan D. Lünemann, Sophie Lehnerer, Sarah Hoffmann, Andreas Meisel   +14 more
wiley   +1 more source

Extracellular mitochondrial DNA activates complement and is associated with complement activation in patients with out-of-hospital cardiac arrest. [PDF]

Sci Rep
de Boer E, Strandmoe AL, Sokolova M, Michelsen TM, Quach HQ, Chaban V, Nakstad ER, Andersen GØ, Torp MS, Stensløkken KO, Mollnes TE, Pischke SE.   +11 more
europepmc   +1 more source

Circulating dsDNA, endothelial injury, and complement activation in thrombotic microangiopathy and GVHD.

Blood, 2017
N. Gloude, P. Khandelwal, Nathan Luebbering, Dana T. Lounder, S. Jodele, M. Alder, A. Lane, Alyss Wilkey, K. Lake, Bridget Litts, S. Davies   +10 more
semanticscholar   +1 more source

Olink Proteomics Analysis Reveals Heterogeneous Responses to FcRn Blockade in Anti‐AChR Antibody‐Positive Myasthenia Gravis: FGF‐19 as a Novel Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo, Deyou Peng, Zhouao Zhang, Mingjin Yang, Xinyan Guo, Tianyu Ma, Xiaoyu Huang, Mingming Xu, Linlin Fu, Yong Zhang   +9 more
wiley   +1 more source

Complement activation by the artificial surface of cardiopulmonary bypass is a persistent clinical problem. [PDF]

Sci Rep
Bierer JD, Stanzel R, Henderson M, El-Rabahi T, Sapp J, Andreou P, Marshall JS, Conrad D, Horne D.   +8 more
europepmc   +1 more source

The Classical Activation Pathway of the Human Complement System Is Specifically Inhibited by Calreticulin from Trypanosoma cruzi [PDF]

, 2004
Viviana P. Ferreira, Carolina Valck, Gittith Sánchez, Alexandre R. Gingras, Sotiria Tzima, Marı́a Carmen Molina, Robert B. Sim, Wilhelm Schwaeble, Arturo Ferreira   +8 more
openalex   +1 more source

Reduced Muscular Carnosine in Proximal Myotonic Myopathy—A Pilot 1H‐MRS Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Myotonic dystrophy type 2 (proximal myotonic myopathy, PROMM) is a progressive multisystem disorder with muscular symptoms (proximal weakness, pain, myotonia) and systemic manifestations such as diabetes mellitus, cataracts, and cardiac arrhythmias.
Alexander Gussew, Maryam Kargaran, Maik Rothe, Andreas Deistung, Dietrich Stoevesandt, Walter A. Wohlgemuth, David Strube, Thomas Kendzierski, Anna Katharina Kölsch, Maurits Gerhard Abraham Heuschen, Markus Otto, Alexander Mensch   +11 more
wiley   +1 more source

In vitro complement activation via nucleocapsid and spike proteins of SARS-CoV-2 in COVID-19 patients. [PDF]

Sci Rep
Kiszel P, Miklós J, Kajdácsi E, Sinkovits G, Cervenak L, Prohászka Z.   +5 more
europepmc   +1 more source

Cytokine induction by circulating immune complexes and signs ofin-vivocomplement activation in systemic lupus erythematosus are associated with the occurrence of anti-Sjögren's syndrome A antibodies

, 2007
Linda Mathsson, Erik Åhlin, Christopher Sjöwall, Thomas Skogh, J Rönnelid   +4 more
openalex   +1 more source

Cholesterol Crystals Activate the Lectin Complement Pathway via Ficolin-2 and Mannose-Binding Lectin: Implications for the Progression of Atherosclerosis [PDF]

, 2016
Katrine Pilely, Anne Rosbjerg, Ninette Genster, Péter Gál, Gábor Pál, Bente Halvorsen, Sverre Holm, Pål Aukrust, Siril S. Bakke, Bjørnar Sporsheim, Ingunn Nervik, Nathalie Niyonzima, Emil D. Bartels, Gregory L. Stahl, Tom Eirik Mollnes, Terje Espevik, Peter Garred   +16 more
openalex   +1 more source