Results 211 to 220 of about 325,802 (246)
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Immunology Today, 1981
When activated, the system of serum proteins known as complement is involved in a wide variety of responses to inflammatory and noxious stimuli. In this article Eric Brown and Michael Frank review the activation of complement by the classical and alternative pathways and discuss some of its biological effects.
E J, Brown, M M, Frank
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When activated, the system of serum proteins known as complement is involved in a wide variety of responses to inflammatory and noxious stimuli. In this article Eric Brown and Michael Frank review the activation of complement by the classical and alternative pathways and discuss some of its biological effects.
E J, Brown, M M, Frank
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Initiation of Complement Activation
Springer Seminars in Immunopathology, 1984The complement system is an excellent one to look at as an example of a triggered enzyme system. It is found to use almost all the strategies of enzyme cascades and for initiation which were discussed in the introduction. The classical pathway is a fine example of an active zymogen form of activation and the alternative pathway is the canonical example
P J, Lachmann, N C, Hughes-Jones
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The Journal of Immunology, 1962
Summary A test has been devised to measure hemolytic complement activity of mouse serum. The chief requirement for detecting mouse hemolytic complement is the use of extremely large amounts of sensitizing antibody. The hemolytic factor measured in mouse serum is indeed complement.
Rosenberg, L T, Tachibana, D K
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Summary A test has been devised to measure hemolytic complement activity of mouse serum. The chief requirement for detecting mouse hemolytic complement is the use of extremely large amounts of sensitizing antibody. The hemolytic factor measured in mouse serum is indeed complement.
Rosenberg, L T, Tachibana, D K
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Complement activation in pneumonia
Medical Microbiology and Immunology, 1979Complement analyses performed on serially collected plasma samples from 10 patients during acute infectious pneumonia or bronchopneumonia showed normal or increased values for hemolytic activity and Clq, C4, C3, and factor B levels. However, the levels of C3 breakdown products (C3d) were significantly (greater than 2 SD) increased in six patients ...
U, Nydegger +4 more
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COMPLEMENT ACTIVATION IN MIGRAINE
The Lancet, 1977Forty patients attending the Prince Henry Hospital migraine clinic have been investigated for evidence of complement activation related to migraine. These patients had a history of clinically similar migraine attacks. Levels of serum complement components were determined in nine patients, both in and out of migraine.
G D, Lord +2 more
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Complement activation in psoriasis
Clinical and Experimental Dermatology, 1990Plasma from 16 patients with psoriasis and 12 healthy control subjects were measured for iC3b, C4d, and Bb fragments generated by complement activation. Plasma concentrations for iC3b, C4d, and Bb fragments were found to be significantly increased in the patients with psoriasis.
E W, Rosenberg +4 more
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Complement activation and atherosclerosis
Molecular Immunology, 1999Atherosclerosis is an inflammatory disease mediated through the action of monocyte/macrophages, complement and T-lymphocytes. C5a and monocyte chemotactic factor released during complement activation in the arterial wall may participate in the initial monocyte recruitment. Assembly of C5b-9 on cells of the arterial wall may also induce cell lysis.
F, Niculescu, H, Rus
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Staphylococcus disrupts complement activation
Nature Reviews Microbiology, 2021This study shows that one mechanism of immune evasion used by Staphylococcus aureus involves a virulence factor, SpA, which can block complement activation by inhibiting IgG oligomerization.
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Complement activation during CAPD
Nephrology Dialysis Transplantation, 1993Abstract Complement activation was monitored in 20 CAPD patients and 20 normal individuals using markers of the alternative (Bb fragment), classical (C4d fragment), common (iC3b) and terminal pathways (SC5b-9, the soluble form of the membrane attack complex, MAC), together with C3, C4 and factor B.
G A, Young, S, Kendall, A M, Brownjohn
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Biological Activities of Complement
Biochemical Society Transactions, 1978Complement is a system of serum proteins whose main function is to defend the body against infection. Although it has a reputation as a dauntingly complex system, this results chiefly from confusion in the nomenclature, which has varied considerably with time as more components were discovered, for example as ‘component C3’ became subdivided into ...
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