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Activation of the Complement Cascade by Trypsin
Biological Chemistry Hoppe-Seyler, 1991In twenty-three patients with acute pancreatitis, the plasma levels of immunoreactive trypsin were determined with a RIA method. The patients were divided into groups according to the severity of the disease. Ranson's criteria and the development of multisystem organ failure were used for the classification.
L, Roxvall +3 more
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The Proteolytic Activation Systems of Complement
Annual Review of Biochemistry, 1981CLASSICAL PATHWAY OF COMPLEMENT ACTIVATION ... . . . . . . ...... . Structure 0/ Components . CI (Clq. Clr. and CIs) . Component C2 . Component C4 ....... . . Components C3 ant!.. C5 . Control proteins (CI inhibitor and C4b binding protein) concerned with regulation of cT and C4b . C Obl :n ; ! ': b.2 :::::::::::::::::::::::::::::::::::
K B, Reid, R R, Porter
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Activation of the Complement System
1973The complement system is a mediator of a number of biologically important reactions which range from cytotoxicity of antibody-sensitized cells, bacteria, and viruses to mediation of inflammatory processes. The components of the system are a number of normal serum proteins which are present in the circulation as functionally inactive precursor molecules.
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Activation of Complement in IgA Nephropathy
American Journal of Kidney Diseases, 1988Considerable evidence supports a role for the complement system in the pathogenesis of IgA nephropathy (IgAN). The alternative pathway components C3 and properdin (P) and the membrane attack complex (C5b-9) are generally found in the mesangial deposits in IgAN, while the classical pathway components C1q and C4 are usually absent.
R J, Wyatt, B A, Julian
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Activation of the First Component of Complement
Annual Review of Immunology, 1987Recent physical and chemical studies have contributed substantially to our knowledge of the structures of subcomponents Clq, Clr, and CIs and their assembly into Cl. Kinetic studies have provided new insight into the activation process, particularly the central role played by C1-inhibitor: This protein appears to be loosely associated with the Cl ...
V N, Schumaker, P, Zavodszky, P H, Poon
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Complement activation by cigarette smoke
American Journal of Physiology-Lung Cellular and Molecular Physiology, 1991Lung disease secondary to cigarette smoking is associated with an influx of neutrophils and monocytes into the lower respiratory tract. To determine whether cigarette smoke can generate chemotactic activity, human serum was exposed to cigarette smoke and evaluated for neutrophil and monocyte chemotactic activity.
R A, Robbins +4 more
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Complement activation in hypercholesterolemia.
Nutrition, metabolism, and cardiovascular diseases : NMCD, 2000Inflammatory and lipid factors share an important role in atherosclerosis. This study evaluates their relations in dyslipidemic subjects.We compared the complement system (serum hemolytic activity CH50, C3 and C4 fractions and terminal complex sC5b-9) in 30 hypercholesterolemic patients with elevated cholesterol and decreased HDL-cholesterol levels, 30
PASQUI A. L. +5 more
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Complement activation by (auto-) antibodies
Molecular Immunology, 2011The complement system is a key part of the innate immune system and plays an important role in the clearance of pathogens and apoptotic cells upon its activation. It is well known that both IgG and IgM can activate complement via the classical pathway by binding of C1q to the Fc regions of these immunoglobulins. Recent advances have shown that also IgA
Daha, N.A. +6 more
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Staphylococcus disrupts complement activation
Nature Reviews Microbiology, 2021Grant Otto, Otto Grant
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