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Biological Activities of Complement
Biochemical Society Transactions, 1978Complement is a system of serum proteins whose main function is to defend the body against infection. Although it has a reputation as a dauntingly complex system, this results chiefly from confusion in the nomenclature, which has varied considerably with time as more components were discovered, for example as ‘component C3’ became subdivided into ...
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Assays for Complement Activation
Clinics in Laboratory Medicine, 1986Complement is a major biologic mediation system that functions in host defense against microorganisms and other pathogens and also aids in the elimination of damaged and abnormal cells. This is accomplished by its ability to mediate the destruction of pathogens and altered cells directly through cytolytic and cytotoxic properties, as well as indirectly
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Complement Activation and Pregnancy Failure
Clinical Reviews in Allergy & Immunology, 2009Pregnancy represents a physiologic condition where maternal immune system tolerates the semi-allogenic fetus. The fetal tissues are directly exposed to the maternal blood with potential attacks from maternal immune system, including the activation of complement cascade. Small amounts, of both early and late components, of complement are physiologically
TINCANI, Angela +5 more
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Activation of the Complement System
1973The complement system is a mediator of a number of biologically important reactions which range from cytotoxicity of antibody-sensitized cells, bacteria, and viruses to mediation of inflammatory processes. The components of the system are a number of normal serum proteins which are present in the circulation as functionally inactive precursor molecules.
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Complement activation in hypercholesterolemia.
Nutrition, metabolism, and cardiovascular diseases : NMCD, 2000Inflammatory and lipid factors share an important role in atherosclerosis. This study evaluates their relations in dyslipidemic subjects.We compared the complement system (serum hemolytic activity CH50, C3 and C4 fractions and terminal complex sC5b-9) in 30 hypercholesterolemic patients with elevated cholesterol and decreased HDL-cholesterol levels, 30
PASQUI A. L. +5 more
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Ficolins in complement activation
Molecular Immunology, 2013Ficolins are a group of multimeric lectins made up of single subunits each of which is composed of a collagen-like domain and a fibrinogen-like domain. Most of the ficolins identified to date bind to acetylated compounds such as N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc).
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Immunoglobulin flexibility in complement activation
Immunology Today, 1986Next to antigen-binding, the interaction between antibody and complement is among the most familiar and well-studied of all immunological events. Now that many of the molecular details are known, antibody-mediated complement activation provides a fascinating example of the subtle relationship between protein structure and function.
A, Feinstein +2 more
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Activation of the Complement Cascade by Trypsin
Biological Chemistry Hoppe-Seyler, 1991In twenty-three patients with acute pancreatitis, the plasma levels of immunoreactive trypsin were determined with a RIA method. The patients were divided into groups according to the severity of the disease. Ranson's criteria and the development of multisystem organ failure were used for the classification.
L, Roxvall +3 more
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Complement activation by carbon nanotubes
Advanced Drug Delivery Reviews, 2011Carbon nanotube interaction with an important part of the innate immune system, complement, needs to be taken into account when envisaging their use in biomedical applications. Carbon nanotubes (CNTs) and other synthetic materials are recognized by various components of the complement system in human or mammalian blood and also collectins in the lungs.
Malgorzata J, Rybak-Smith, Robert B, Sim
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Complement Activation by Neutrophil Granulocytes
Scandinavian Journal of Immunology, 2008Abstract Complement plays a vital role in the body’s defence systems. Cardiopulmonary bypass induces a detrimental inflammatory reaction in which the complement system is known to participate through direct effects as well as through activation of neutrophils, platelets and endothelial cells.
A E, Asberg, T E, Mollnes, V, Videm
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