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Monomeric Complement-Activating IgG Paraproteins
The Journal of Immunology, 1999AbstractThree patients presented a unique syndrome of recurrent panniculitis with an IgGκ paraprotein and depletion of the early components of the classical pathway of complement. The IgGκ paraproteins were monomers with a normal structure, and with no evidence for aggregation, as assessed by electron microscopy and ultracentrifugation.
M, Trendelenburg +5 more
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Examining coagulation-complement crosstalk: complement activation and thrombosis
Thrombosis Research, 2016The coagulation and complement systems are ancestrally related enzymatic cascades of the blood. Although their primary purposes have diverged over the past few hundred million years, they remain inextricably connected. Both complement and coagulation systems limit infection by pathogens through innate immune mechanisms. Recently, it has been shown that
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Complement Activation by Cold Agglutinins
Vox Sanguinis, 1992AbstractPurified monoclonal human IgM cold agglutinins (CA) of different specificities (anti‐I, anti‐i, anti‐Pr) were investigated for their complement‐activating capacity in a homologous system. Incubation of human RBC with excess of IgM CA in the cold, and subsequently with human serum at 37°C, resulted in striking differences in hemolysis. Hemolysis
M, Kirschfink, H, Fritze, D, Roelcke
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Complement Activation in Renal Disease
Uremia Investigation, 1984Perturbation of the serum complement system in glomerulonephritis can be the result of classical pathway activation by immune complexes or of C3 activation by the C3-C5 convertase stabilized by the C3 nephritic factor. Low C3 levels can also be the result of diminished C3 synthesis and possibly, in certain circumstances, of C3 convertases deposited on ...
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Complement activation induces excessive T cell cytotoxicity in severe COVID-19
Cell, 2022Philipp Georg +2 more
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