Results 31 to 40 of about 4,342,004 (341)

Complement Activation Levels Are Related to Disease Stage in AMD

Investigative Ophthalmology and Visual Science, 2020
Purpose To study the levels of complement activation in different disease stages of AMD and the influence of genetic polymorphisms in complement genes.
Thomas J. Heesterbeek, Y. Lechanteur, L. Lorés-Motta, T. Schick, M. Daha, L. Altay, S. Liakopoulos, D. Smailhodzic, A. D. den Hollander, C. Hoyng, E. D. de Jong, B. Klevering   +11 more
semanticscholar   +1 more source

Using animal models to determine the significance of complement activation in Alzheimer's disease

Journal of Neuroinflammation, 2004
Complement inflammation is a major inflammatory mechanism whose function is to promote the removal of microorganisms and the processing of immune complexes.
Loeffler David A
doaj   +1 more source

Essential Role of Complement in Pregnancy: From Implantation to Parturition and Beyond

Frontiers in Immunology, 2020
The complement cascade was identified over 100 years ago, yet investigation of its role in pregnancy remains an area of intense research. Complement inhibitors at the maternal-fetal interface prevent inappropriate complement activation to protect the ...
Guillermina Girardi, Joshua J. Lingo, Sherry D. Fleming, Jean F. Regal   +3 more
doaj   +1 more source

Beyond Binding: The Outcomes of Antibody-Dependent Complement Activation in Human Malaria

Frontiers in Immunology, 2021
Antibody immunity against malaria is effective but non-sterile. In addition to antibody-mediated inhibition, neutralisation or opsonisation of malaria parasites, antibody-mediated complement activation is also important in defense against infection ...
Dilini Rathnayake, Elizabeth H. Aitken, Stephen J. Rogerson   +2 more
doaj   +1 more source

Complement activation in sickle cell disease: Dependence on cell density, hemolysis and modulation by hydroxyurea therapy

American journal of hematology/oncology, 2020
The complement system is an innate immune defense cascade that can cause tissue damage when inappropriately activated. Evidence for complement over activation has been reported in small cohorts of patients with sickle cell disease (SCD).
L. Roumenina, P. Chadebech, G. Bodivit, Paula Vieira-Martins, Anne Grunenwald, I. Boudhabhay, Victoria Poillerat, Sadaf Pakdaman, L. Kiger, Alicia Jouard, E. Audureau, F. Pirenne, F. Galactéros, V. Frémeaux-Bacchi, P. Bartolucci   +14 more
semanticscholar   +1 more source

Clinical relevance of glomerular IgM deposition in patients with lupus nephritis

BMC Immunology, 2021
Background The aim of the study was to investigate the clinical relevance of IgM deposition in patients with lupus nephritis (LN) in a large cohort. Results 217 patients with renal biopsy-proven active LN were enrolled.
Fengmei Wang, Jirong Yu, Lei Zhang, Yan Zhang, Jie Zhang, Bicheng Liu, Xiaowei Yang   +6 more
doaj   +1 more source

Complement activation in obesity, insulin resistance, and type 2 diabetes mellitus

World Journal of Diabetes, 2020
Amplified inflammatory reaction has been observed to be involved in cardiometabolic diseases such as obesity, insulin resistance, diabetes, dyslipidemia, and atherosclerosis.
Kyumin Shim, R. Begum, Catherine F Yang, Hongbin Wang   +3 more
semanticscholar   +1 more source

Complement Proteins as Soluble Pattern Recognition Receptors for Pathogenic Viruses

Viruses, 2021
The complement system represents a crucial part of innate immunity. It contains a diverse range of soluble activators, membrane-bound receptors, and regulators.
Valarmathy Murugaiah, Praveen M. Varghese, Nazar Beirag, Syreeta De Cordova, Robert B. Sim, Uday Kishore   +5 more
doaj   +1 more source

Staphylococcal protein A inhibits complement activation by interfering with IgG hexamer formation

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Antibodies are crucial for the immune response against bacteria. To drive bacterial killing, antibodies should bind to the bacterial cell and induce the complement reaction.
A. R. Cruz, Maurits A. den Boer, Jürgen Strasser, S. Zwarthoff, F. Beurskens, C. D. de Haas, P. Aerts, Guanbo Wang, R. D. de Jong, F. Bagnoli, J. V. van Strijp, K. V. van Kessel, J. Schuurman, J. Preiner, A. Heck, S. Rooijakkers   +15 more
semanticscholar   +1 more source

Antiphospholipid syndrome: Complement activation, complement gene mutations, and therapeutic implications

Journal of Thrombosis and Haemostasis, 2020
Antiphospholipid syndrome (APS) is an acquired thromboinflammatory disorder characterized by the presence of antiphospholipid antibodies as well as an increased frequency of venous or arterial thrombosis and/or obstetrical morbidity.
Shruti Chaturvedi, Evan M. Braunstein, R. Brodsky   +2 more
semanticscholar   +1 more source