Results 61 to 70 of about 4,342,004 (341)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

The Human Platelet as an Innate Immune Cell: Interactions Between Activated Platelets and the Complement System

Frontiers in Immunology, 2019
Platelets play an essential role in maintaining homeostasis in the circulatory system after an injury by forming a platelet thrombus, but they also occupy a central node in the intravascular innate immune system.
Oskar Eriksson, Camilla Mohlin, Bo Nilsson, Kristina N. Ekdahl, Kristina N. Ekdahl   +4 more
doaj   +1 more source

Complement Overactivation and Consumption Predicts In-Hospital Mortality in SARS-CoV-2 Infection

Frontiers in Immunology, 2021
ObjectivesUncontrolled thromboinflammation plays an important role in the pathogenesis of coronavirus disease (COVID-19) caused by SARS-CoV-2 virus. Complement was implicated as key contributor to this process, therefore we hypothesized that markers of ...
György Sinkovits, Blanka Mező, Blanka Mező, Marienn Réti, Veronika Müller, Zsolt Iványi, János Gál, László Gopcsa, Péter Reményi, Beáta Szathmáry, Botond Lakatos, János Szlávik, Ilona Bobek, Zita Z. Prohászka, Zsolt Förhécz, Dorottya Csuka, Lisa Hurler, Erika Kajdácsi, László Cervenak, Petra Kiszel, Tamás Masszi, István Vályi-Nagy, István Vályi-Nagy, Zoltán Prohászka, Zoltán Prohászka   +24 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Pathological significance of urinary complement activation in diabetic nephropathy: A full view from the development of the disease

Journal of Diabetes Investigation, 2019
Aims/Introduction The aim of the present study was to obtain a full view of the changes of urinary complement activation products in the development of diabetic nephropathy and explore their possible significance in the disease process.
Jing‐Min Zheng, Zuan‐Hong Jiang, De‐Jun Chen, Sa‐Sa Wang, Wen‐Jin Zhao, Li‐Juan Li   +5 more
doaj   +1 more source

Understanding the Role of Anti-PEG Antibodies in the Complement Activation by Doxil in Vitro

Molecules, 2018
Infusion reactions (IRs) are common immune-mediated side effects in patients treated with a variety of drug products, including, but not limited to, nanotechnology formulations. The mechanism of IRs is not fully understood.
B. Neun, Y. Barenholz, J. Szebeni, M. Dobrovolskaia   +3 more
semanticscholar   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

VERSATILITY OF THE COMPLEMENT SYSTEM IN NEUROINFLAMMATION, NEURODEGENERATION AND BRAIN HOMEOSTASIS

Frontiers in Cellular Neuroscience, 2014
The immune response after brain injury is highly complex and involves both local and systemic events at the cellular and molecular level. It is associated to a dramatic over-activation of enzyme systems, the expression of proinflammatory genes and the ...
Franca eOrsini, Daiana eDe Blasio, Daiana eDe Blasio, Rosalia eZangari, Rosalia eZangari, Elisa R. Zanier, Maria-Grazia eDe Simoni   +6 more
doaj   +1 more source

Complement and Cancer—A Dysfunctional Relationship?

Antibodies, 2020
Although it was long believed that the complement system helps the body to identify and remove transformed cells, it is now clear that complement activation contributes to carcinogenesis and can also help tumors to escape immune-elimination.
Joshua M. Thurman, Jennifer Laskowski, Raphael A. Nemenoff   +2 more
doaj   +1 more source

Dendrimer end-terminal motif-dependent evasion of human complement and complement activation through IgM hitchhiking

Nature Communications, 2021
Understanding nanomaterials interactions with complement is important for a number of applications. Here, the authors study the interaction of sub 6 nm dendrimers with complement and show the small dendrimers escape complement activation but do interact ...
Lin-Ping Wu, Mario Ficker, Jørn B. Christensen, Dmitri Simberg, Panagiotis N. Trohopoulos, Seyed M. Moghimi   +5 more
doaj   +1 more source