Results 61 to 70 of about 638,552 (336)

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

The Human Platelet as an Innate Immune Cell: Interactions Between Activated Platelets and the Complement System

Frontiers in Immunology, 2019
Platelets play an essential role in maintaining homeostasis in the circulatory system after an injury by forming a platelet thrombus, but they also occupy a central node in the intravascular innate immune system.
Oskar Eriksson, Camilla Mohlin, Bo Nilsson, Kristina N. Ekdahl, Kristina N. Ekdahl   +4 more
doaj   +1 more source

Dendrimer end-terminal motif-dependent evasion of human complement and complement activation through IgM hitchhiking

Nature Communications, 2021
Understanding nanomaterials interactions with complement is important for a number of applications. Here, the authors study the interaction of sub 6 nm dendrimers with complement and show the small dendrimers escape complement activation but do interact ...
Lin-Ping Wu, Mario Ficker, Jørn B. Christensen, Dmitri Simberg, Panagiotis N. Trohopoulos, Seyed M. Moghimi   +5 more
doaj   +1 more source

C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy [PDF]

, 2016
Introduction Guillain-Barré syndrome (GBS) is an autoimmune disease that results in acute paralysis through inflammatory attack on peripheral nerves, and currently has limited, non-specific treatment options.
Barrie, Jennifer A., Cunningham, Madeleine E., Fewou, Simon N., Furukawa, Koichi, McGonigal, Rhona, Sankaranarayanan, Sethu, Willison, Hugh J., Yao, Denggao, Yednock, Ted A.   +8 more
core   +2 more sources

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Complement Factor D as a Strategic Target for Regulating the Alternative Complement Pathway

Frontiers in Immunology, 2021
The complement system is central to first-line defense against invading pathogens. However, excessive complement activation and/or the loss of complement regulation contributes to the development of autoimmune diseases, systemic inflammation, and ...
Jonathan Barratt, Jonathan Barratt, Ilene Weitz   +2 more
doaj   +1 more source

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

FEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki, Masae Ohtsuka, Takeshi Nakano, Masaru Tanokura, Takuya Miyakawa   +4 more
wiley   +1 more source

Borrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components [PDF]

, 2013
Spirochetes belonging to the Borrelia (B.) burgdorferi sensu lato complex differ in their resistance to complement-mediated killing, particularly in regard to human serum.
A Alitalo, A Alitalo, A Alitalo, A Seling, AC Steere, AM Blom, Andreas Klos, AP van Dam, B Stevenson, C Hammerschmidt, C Siegel, C Siegel, Christine Skerka, Claudia Hammerschmidt, CS Brooks, Dania Richter, E Diza, F Strle, Franz-Rainer Matuschka, H Jiang, H Michel, J Hellwage, J Pietikainen, J Potempa, Jasmin Schwab, JD Lambris, JV McDowell, K Hartmann, K Haupt, K Kurtenbach, K Kurtenbach, K Saito, K Whaley, KM Hovis, KP Hunfeld, L Beinrohr, M Collares-Pereira, M Jusko, M Józsi, MJ Walport, MK Pangburn, MR Bhide, MR Bhide, MR Kenedy, MS Metts, N Marr, ND van Burgel, P Herzberger, P Herzberger, P Kraiczy, P Kraiczy, P Kraiczy, P Kraiczy, P Kraiczy, P Kraiczy, P Ramu, Peter F. Zipfel, Peter Kraiczy, PF Zipfel, PF Zipfel, R Dieterich, R Wallich, Reinhard Wallich, RG Discipio, RJ Ziccardi, S Breitner-Ruddock, S Grosskinsky, S Grosskinsky, S Heinen, S Kühn, SC Bock, SG Rijpkema, SH Rooijakkers, T Fujita, T Fujita, V Brade, Y Terao   +76 more
core   +9 more sources

Complement Overactivation and Consumption Predicts In-Hospital Mortality in SARS-CoV-2 Infection

Frontiers in Immunology, 2021
ObjectivesUncontrolled thromboinflammation plays an important role in the pathogenesis of coronavirus disease (COVID-19) caused by SARS-CoV-2 virus. Complement was implicated as key contributor to this process, therefore we hypothesized that markers of ...
György Sinkovits, Blanka Mező, Blanka Mező, Marienn Réti, Veronika Müller, Zsolt Iványi, János Gál, László Gopcsa, Péter Reményi, Beáta Szathmáry, Botond Lakatos, János Szlávik, Ilona Bobek, Zita Z. Prohászka, Zsolt Förhécz, Dorottya Csuka, Lisa Hurler, Erika Kajdácsi, László Cervenak, Petra Kiszel, Tamás Masszi, István Vályi-Nagy, István Vályi-Nagy, Zoltán Prohászka, Zoltán Prohászka   +24 more
doaj   +1 more source

The differential ability of human IgG1 and IgG4 to activate complement is determined by the COOH-terminal sequence of the CH2 domain. [PDF]

, 1991
Using domain switch chimeric antibodies, we confirm the important role of CH2 in complement activation. In addition, we demonstrate that the structures responsible for the differential ability of human IgG1 and IgG4 to activate complement are located at ...
Canfield, SM, Morrison, SL, Tao, MH
core