Results 221 to 230 of about 275,985 (253)

Clionasterol: A Potent Inhibitor of Complement Component C1

Planta Medica, 2003
Clionasterol (1a), clionasterol monoacetate (1b) and 5alpha,8alpha-epidioxy-24alpha-ethylcholest-6-en-3-ol (2), isolated from the marine sponge Xestospongia exigua, and beta-sitosterol (3) were tested for their influence on the classical (CP) and alternative (AP) pathways of activation of the human complement system in vitro.
Fátima, Cerqueira, Rawiwan, Watanadilok, Pichai, Sonchaeng, Anake, Kijjoa, Madalena, Pinto, Henriette, Quarles van Ufford, Burt, Kroes, Cees, Beukelman, Maria São José, Nascimento   +8 more
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Functional model of subcomponent C1 of human complement

Journal of Molecular Biology, 1986
The domain organization of the zymogen subunits of the first component of human complement C1s, C1r2 and the complex C1s-C1r2-C1s was studied by electron microscopy. In the absence of Ca2+, monomeric C1s was visualized as a dumb-bell-shaped molecule consisting of two globular domains (center-to-center distance 11 nm) connected by a rod.
V, Weiss, C, Fauser, J, Engel
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Inhibition of bFGF activity by complement C1s: covalent binding of C1s with bFGF

Cell Biochemistry and Function, 1998
The first complement component C1s formed large aggregates with bFGF when bFGF and C1s were incubated at 37 degrees C overnight. Under non-reducing conditions, a part of the aggregates did not penetrate into 5% polyacrylamide gel in the presence of SDS, and the rest penetrated into 5% gel but not into 12% gel.
H, Sakiyama, K, Kaji, K, Nakagawa, K, Nagino   +3 more
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C1, MBL–MASPs and C1-inhibitor: novel approaches for targeting complement-mediated inflammation

Trends in Molecular Medicine, 2008
Complement activation is initiated by the pattern-recognition molecules complement component C1q, mannose-binding lectin (MBL) and ficolins (H-, L-, M-ficolin), which typically recognize antibody-antigen complexes or foreign polysaccharides. The associated proteases (C1r, C1s, MASP-1 and MASP-2) then activate the complement system.
László, Beinrohr, József, Dobó, Péter, Závodszky, Péter, Gál   +3 more
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Biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s

Bioorganic & Medicinal Chemistry Letters, 2008
Complement activation has been implicated in disease states such as hereditary angioedema, ischemia-reperfusion injury, acute respiratory distress syndrome, and acute transplant rejection. Even though the complement cascade provides several protein targets for potential therapeutic intervention only two complement inhibitors have been approved so far ...
Jeremy M, Travins, Farah, Ali, Hui, Huang, Shelley K, Ballentine, Ehab, Khalil, Heather R, Hufnagel, Wenxi, Pan, Joan, Gushue, Kristi, Leonard, Roger F, Bone, Richard M, Soll, Renee L, DesJarlais, Carl S, Crysler, Nisha, Ninan, Jennifer, Kirkpatrick, Maxwell D, Cummings, Norman, Huebert, Christopher J, Molloy, Michael, Gaul, Bruce E, Tomczuk, Nalin L, Subasinghe   +20 more
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Purification and characterization of recombinant hamster tissue complement C1s

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1995
Hamster complement C1s cDNA was inserted into expression plasmid BCMGSNeo, and transfected to SEA7 cells, A31 mouse fibroblasts transformed by polyoma virus. The transfectant secreted a large amount of recombinant C1s that was activated in the serum free culture medium and hydrolyzed acetyl-Gly-L-Lys-naphthyl ester (AGLNE).
T, Toyoguchi, K, Yamaguchi, S, Imajoh-Ohmi, N, Kato, M, Kusunoki, H, Kageyama, S, Sakiyama, S, Nagasawa, H, Moriya, H, Sakiyama   +9 more
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Identification of the disulfide bonds of human complement C1s

Biochemistry, 1991
C1s, one of the three subcomponents of C1, the first component of the complement system, is a complex serine protease. To determine the disulfide-bonding pattern, fragments of C1s were generated by cleavage with pepsin, thermolysin, or subtilisin.
D, Hess, J, Schaller, E E, Rickli
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Detection of complement C1-inhibitor with a piezoelectric immunosensor

Fresenius' Journal of Analytical Chemistry, 2001
A novel piezoelectric immunosensor has been developed for the detection of human complement C1-inhibitor. Anti-C1-inhibitor antibody was immobilized onto the gold electrodes of a 9 MHz AT-cut piezoelectric crystal. Coating the crystal with polyethyleneimine adhesion, followed by a glutaraldehyde cross-linking method to immobilize antibody showed better
L, Liu, J, Hu, L, Wang, L, Liu, X, Zhou
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Biochemical characterization and tissue distribution of hamster complement C1s

The Journal of Immunology, 1991
Abstract Several mAb (PG11, NG7, and ED4) against hamster complement C1s were obtained. PG11 and NG7 were shown to cross-react with human and rat C1s. By using an immunohistochemical method, we examined localization of C1s in tissues of hamsters and rats. Present results revealed a widespread yet specific staining of hamster C1s which is
H, Sakiyama, K, Yamaguchi, K, Chiba, K, Nagata, C, Taniyama, M, Matsumoto, G, Suzuki, T, Tanaka, T, Tomoasawa, M, Yasukawa   +9 more
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Complement Components, C1 Activation and Disease Activity in SLE

International Archives of Allergy and Immunology, 1983
Laboratory parameters were studied in 8 systemic lupus erythematosus patients during periods of high and low disease activity, mainly as defined by clinical criteria. Renal manifestations were present in 6 patients 5 of which showed antibodies to native DNA. C-reactive protein was raised in 3 patients.
G, Sturfelt, A G, Sjöholm, B, Svensson
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