Results 31 to 40 of about 275,985 (253)
Nature Communications, 2023 IgG3 is unique among the IgG subclasses due to its extended hinge, allotypic diversity and enhanced effector functions, including highly efficient pathogen neutralisation and complement activation.
Leoni Abendstein +6 more
doaj +1 more source
Identification of defensin binding to C1 complement [PDF]
FEBS Letters, 1994 In human serum we found strong defensin binding to the complexes of activated C1 complement (C) and C1 inhibitor (C1i). Purified C1q, activated C1 tetramer ( 2 2) and C1i did not bind defensin. When ( 2 2) was dissociated by EDTA, only the activated C1s (Cs) bound defensin.
Panyutich, Alexander V. +4 more
openaire +2 more sources
The correlation between inflammatory biomarkers and polygenic risk score in Alzheimer's Disease [PDF]
, 2017 Plasma biomarkers to aid the early diagnosis of Alzheimer’s disease (AD) or to monitor disease progression have long been sought and continue to be widely studied.
Escott-Price, Valentina +8 more
core +1 more source
PLoS ONE, 2016 The serpin C1 inhibitor (C1-INH) is the only regulator of classical complement activation as well as the major regulator of the contact system. Its importance is demonstrated by hereditary angioedema (HAE), a severe disease with potentially life ...
Ann-Kathrin Schoenfeld +2 more
doaj +1 more source
Frontiers in Allergy, 2022 BackgroundHereditary Angioedema with C1-inhibitor deficiency (C1-INH-HAE) is a rare disease characterized by recurrent subcutaneous and/or submucosal edematous (HAE) episodes, which may occur at any age.
Noémi Andrási +10 more
doaj +1 more source
Structure of the C1 complex of complement [PDF]
Proceedings of the National Academy of Sciences, 2017 In PNAS, Mortensen et al. (1) propose a model of the C1 complex of complement derived from small-angle X-ray scattering (SAXS) and electron microscopy (EM) analyses that contradicts previously published models and suggests an intermolecular activation process. This proposal is largely derived from a conjectural structure of C1r2C1s2, the catalytic unit
Arlaud, Gérard J +3 more
openaire +4 more sources
C1-inactivator is upregulated in glioblastoma.
PLoS ONE, 2017 BackgroundGlioblastoma is the most common and aggressive type of primary brain tumor in adults. A key problem is the capacity of glioma cells to inactivate the body's immune response.
Karolina Förnvik +5 more
doaj +1 more source
Human oligodendroglial cells express low levels of C1 inhibitor and membrane cofactor protein mRNAs
Journal of Neuroinflammation, 2004 Background Oligodendrocytes, neurons, astrocytes, microglia, and endothelial cells are capable of synthesizing complement inhibitor proteins. Oligodendrocytes are vulnerable to complement attack, which is particularly observed in multiple sclerosis. This
McGeer Patrick L +2 more
doaj +1 more source
Clique-Stable Set separation in perfect graphs with no balanced skew-partitions [PDF]
, 2016 Inspired by a question of Yannakakis on the Vertex Packing polytope of perfect graphs, we study the Clique-Stable Set Separation in a non-hereditary subclass of perfect graphs.
Lagoutte, Aurélie, Trunck, Théophile
core +5 more sources
Сахарный диабет, 2011 Aim. Comparative analysis of the levels of the membrane attack complex (MAC) - an end product of complement activation, and of hemolytic activitiesof C1 and C3 complement components in sera of patients with diabetes mellitus 2 (DM2) and healthy subjects.
Elina Alexandrovna Arakelova +5 more
doaj +1 more source