Results 41 to 50 of about 275,985 (253)

A Novel C1-Esterase Inhibitor Oxygenator Coating Prevents FXII Activation in Human Blood

Biomolecules, 2020
The limited hemocompatibility of currently used oxygenator membranes prevents long-term use of artificial lungs in patients with lung failure. To improve hemocompatibility, we developed a novel covalent C1-esterase inhibitor (C1-INH) coating.
Katharina Gerling, Sabrina Ölschläger, Meltem Avci-Adali, Bernd Neumann, Ernst Schweizer, Christian Schlensak, Hans-Peter Wendel, Sandra Stoppelkamp   +7 more
doaj   +1 more source

Complement Activation in the Central Nervous System: A Biophysical Model for Immune Dysregulation in the Disease State

Frontiers in Molecular Neuroscience, 2021
Complement, a feature of the innate immune system that targets pathogens for phagocytic clearance and promotes inflammation, is tightly regulated to prevent damage to host tissue.
Nicholas Peoples, Candace Strang
doaj   +1 more source

A polyhedral approach for the Equitable Coloring Problem [PDF]

, 2011
In this work we study the polytope associated with a 0,1-integer programming formulation for the Equitable Coloring Problem. We find several families of valid inequalities and derive sufficient conditions in order to be facet-defining inequalities.
Bahiense, Campêlo, Daniel Severín, Das, Graciela Nasini, Isabel Méndez-Díaz, Januschowski, Kaibel, Kierstead, Kubale, Lih, Margot, Meyer, Méndez-Díaz, Pemmaraju, Tucker   +15 more
core   +2 more sources

The role of C1 inhibitor and complement as acute phase reactants: are we missing the diagnosis of hereditary angioedema?

Allergy, Asthma & Clinical Immunology, 2021
Background C1 inhibitor (C1-INH) and complement 4 (C4) have historically been referred to as positive acute phase reactants, however this has never been evaluated in hereditary angioedema (HAE) patients.
Peter Stepaniuk, Ana-Maria Bosonea, Persia Pourshahnazari, Adrienne Roos, Amin Kanani   +4 more
doaj   +1 more source

Variably Protease‐Sensitive Prionopathy: Two New Cases With Motor Neuron‐Dementia Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We describe two patients with variably protease‐sensitive prionopathy (VPSPr) who developed progressive upper motor neuron symptoms, insomnia, behavioral and cognitive decline, compatible with primary lateral sclerosis associated with frontotemporal dementia (FTD).
María Elena Erro, María Victoria Zelaya, Hasier Eraña, Javier Sánchez Ruiz de Gordoa, Fermín García‐Amigot, Anika Simonovska‐Serra, María Cristina Caballero, Isidre Ferrer, Ellen Gelpi, Ivonne Jericó, Joaquín Castilla   +10 more
wiley   +1 more source

Angioedema hereditario en Medellín, Colombia: evaluación clínica y de la calidad de vida

Biomédica: revista del Instituto Nacional de Salud, 2015
Introducción. El angioedema hereditario es una inmunodeficiencia primaria de carácter autosómico dominante, debida a un déficit en la proteína inhibidora del factor C1 y caracterizada por episodios recurrentes de edema subcutáneo y de las mucosas.
María Dulfary Sánchez, Julián Cuervo, Deisi Rave, Gustavo Clemen, Juan José Yepes-Núñez, Blanca Ortiz-Reyes, Sara Sus, Ricardo Cardona   +7 more
doaj   +1 more source

Spin correlations in polarizations of P-wave charmonia $\chi_{cJ}$ and impact on $J/\psi$ polarization

, 2014
Based on a general form of the effective vertex functions for the decays of P-wave charmonia $\chicj$, angular distribution formulas for the subsequent decays $\chicj\rightarrow \jpsi \gamma$ and $\jpsi \to \mu^+\mu^-$ are derived.
Chao, Kuang-Ta, Shao, Hua-Sheng
core   +1 more source

Clinical Significance of Therapeutic Drug Level Monitoring for Mycophenolate in Patients with Extra‐Renal Systemic Lupus Erythematosus – A Systematic Review & Meta‐analysis

Arthritis Care &Research, Accepted Article.
Background Clinical response to Mycophenolic acid (MPA) is highly heterogeneous; thus, therapeutic drug monitoring (TDM) may help improve treatment efficacy. This systematic review and meta‐analysis examined therapeutic ranges for MPA levels associated with better outcomes and safety in patients with SLE, particularly those with extra‐renal ...
Zahraa Qamhieh, Dalia Sriwi, Callie Saric, Tripti Singh, Christie M. Bartels, Shivani Garg   +5 more
wiley   +1 more source

The Interactions of Parasite Calreticulin With Initial Complement Components: Consequences in Immunity and Virulence

Frontiers in Immunology, 2020
Because of its capacity to increase a physiologic inflammatory response, to stimulate phagocytosis, to promote cell lysis and to enhance pathogen immunogenicity, the complement system is a crucial component of both the innate and adaptive immune ...
Galia Ramírez-Toloza, Lorena Aguilar-Guzmán, Carolina Valck, Viviana P. Ferreira, Arturo Ferreira   +4 more
doaj   +1 more source

Structure of the C1r–C1s interaction of the C1 complex of complement activation [PDF]

Proceedings of the National Academy of Sciences, 2018
SignificanceC1 is a large complex that triggers the destruction of invading pathogens via lysis or by stimulation of innate and adaptive immune processes. It is composed of C1q, a protein with a bouquet-like architecture, together with a tetramer assembled from two copies each of the serine proteases C1r and C1s, which activate when C1q binds to a ...
Jamal O. M. Almitairi, Umakhanth Venkatraman Girija, Christopher M. Furze, Xanthe Simpson-Gray, Farah Badakshi, Jamie E. Marshall, Wilhelm J. Schwaeble, Daniel A. Mitchell, Peter C. E. Moody, Russell Wallis   +9 more
openaire   +4 more sources