Complement C1q Enhances Primary Hemostasis [PDF]
Frontiers in Immunology, 2020 The cross-talk between the inflammatory complement system and hemostasis is becoming increasingly recognized. The interaction between complement C1q, initiation molecule of the classical pathway, and von Willebrand factor (vWF), initiator molecule of ...
Claudia Donat +6 more
doaj +6 more sources
Prognostic Implications of the Complement Protein C1q in Gliomas [PDF]
Frontiers in Immunology, 2019 The contribution of the complement system in the pathophysiology of brain cancers has been recently considered in light of its well-known involvement in carcinogenesis.
Alessandro Mangogna +10 more
doaj +11 more sources
Serum Complement C1q Activity Is Associated With Obstructive Coronary Artery Disease [PDF]
Frontiers in Cardiovascular Medicine, 2021 Background: Complement C1q plays a dual role in the atherosclerosis. Previous studies showed inconsistent results about the association of serum C1q levels and coronary artery disease (CAD).
Shuren Guo +5 more
doaj +3 more sources
Role of complement C1q/C3-CR3 signaling in brain injury after experimental intracerebral hemorrhage and the effect of minocycline treatment [PDF]
Frontiers in Immunology, 2022 AimThe complement cascade is activated and may play an important pathophysiologic role in brain injury after experimental intracerebral hemorrhage (ICH). However, the exact mechanism of specific complement components has not been well studied. This study
Yonghe Zheng +12 more
doaj +3 more sources
Epigenetic regulation of complement C1Q gene expression. [PDF]
Front ImmunolHuman C1q is a multifaceted complement protein whose functions range from activating the complement classical pathway to immunomodulation and promoting placental development and tumorigenesis.
Pegoraro S +6 more
europepmc +4 more sources
Trichinella spiralis Calreticulin S-Domain Binds to Human Complement C1q to Interfere With C1q-Mediated Immune Functions [PDF]
Frontiers in Immunology, 2020 Helminths develop strategies to escape host immune responses that facilitate their survival in the hostile host immune environment. Trichinella spiralis, a tissue-dwelling nematode, has developed a sophisticated strategy to escape complement attack.
Shuai Shao +7 more
doaj +3 more sources
Trichinella spiralis Paramyosin Binds Human Complement C1q and Inhibits Classical Complement Activation. [PDF]
PLoS Neglected Tropical Diseases, 2015 BACKGROUND:Trichinella spiralis expresses paramyosin (Ts-Pmy) as a defense mechanism. Ts-Pmy is a functional protein with binding activity to human complement C8 and C9 and thus plays a role in evading the attack of the host's immune system.
Ran Sun +6 more
doaj +4 more sources
Complement C1q activates tumor suppressor WWOX to induce apoptosis in prostate cancer cells. [PDF]
PLoS ONE, 2009 BACKGROUND:Tissue exudates contain low levels of serum complement proteins, and their regulatory effects on prostate cancer progression are largely unknown.
Qunying Hong +10 more
doaj +7 more sources
Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer's disease mouse models. [PDF]
Nat Aging, 2022 Microglia and complement can mediate neurodegeneration in Alzheimer’s disease (AD). By integrative multi-omics analysis, here we show that astrocytic and microglial proteins are increased in TauP301S synapse fractions with age and in a C1q-dependent ...
Dejanovic B +21 more
europepmc +2 more sources
Serum complement C1q level is associated with left ventricular hypertrophy induced by coarctation of the aorta: A retrospective observational study [PDF]
BMC Cardiovascular Disorders, 2022 Background The complement system plays an important role in the development of left ventricular hypertrophy. Complement C1q is an initial component of the classical complement pathway and is related to many inflammatory diseases.
Li Chen +6 more
doaj +2 more sources