C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy [PDF]
, 2016 Introduction Guillain-Barré syndrome (GBS) is an autoimmune disease that results in acute paralysis through inflammatory attack on peripheral nerves, and currently has limited, non-specific treatment options.
Barrie, Jennifer A. +8 more
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Interaction between complement subcomponent C1q and bacterial lipopolysaccharides [PDF]
Biochemical Journal, 1989 The heptose-less mutant of Escherichia coli, D31m4, bound complement subcomponent C1q and its collagen-like fragments (C1qCLF) with Ka values of 1.4 x 10(8) and 2.0 x 10(8) M-1 respectively. This binding was suppressed by chemical modification of C1q and C1qCLF using diethyl pyrocarbonate (DEPC).
A, Zohair +3 more
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Complement C1q activates tumor suppressor WWOX to induce apoptosis in prostate cancer cells. [PDF]
PLoS ONE, 2009 BACKGROUND:Tissue exudates contain low levels of serum complement proteins, and their regulatory effects on prostate cancer progression are largely unknown.
Qunying Hong +10 more
doaj +1 more source
Human C1q Induces Apoptosis in an Ovarian Cancer Cell Line via Tumor Necrosis Factor [PDF]
, 2016 Copyright: © 2016 Kaur, Sultan, Murugaiah, Pathan, Alhamlan, Karteris and Kishore. Human C1q is the first recognition subcomponent of the complement classical pathway that plays a vital role in the clearance of immune complexes, pathogens and apoptotic ...
Alhamlan, F +6 more
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C1 Complex: An Adaptable Proteolytic Module for Complement and Non-Complement Functions
Frontiers in Immunology, 2017 Complement C1 is the defining component of the classical pathway. Within the C1qC1r2C1s2 complex, C1q functions as a molecular scaffold for C1r2C1s2 and C1q binding to its ligands activates these two serine proteases.
Jinhua Lu, Uday Kishore
doaj +1 more source
Complement activation and protein adsorption by carbon nanotubes [PDF]
, 2006 As a first step to validate the use of carbon nanotubes as novel vaccine or drug delivery devices, their interaction with a part of the human immune system, complement, has been explored.
Flahaut, Emmanuel +5 more
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Paths reunited: initiation of the classical and lectin pathways of complement activation [PDF]
, 2010 Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago.
Keeble, Anthony H. +4 more
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Complement C1q expression in Erythema nodosum leprosum
PLOS Neglected Tropical Diseases, 2018 Complement C1q is a soluble protein capable of initiating components of the classical pathway in host defence system. In earlier qualitative studies, C1q has been implicated in the pathogenesis of Erythema Nodosum Leprosum (ENL). However, little is known about the role of this complement in ENL reaction.
Edessa Negera +5 more
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Complement Component C1q and Anti‐C1q Antibodies in Theory and in Clinical Practice [PDF]
Scandinavian Journal of Immunology, 2008 AbstractThe complement system is a major part of the innate immunity. The first component of the classical pathway of complement activation, C1q, plays a crucial role in the clearance of immune complexes and apoptotic bodies from the organism. Autoantibodies against C1q (anti‐C1q) have been found in a number of autoimmune and infectious diseases.
E, Potlukova, P, Kralikova
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A common theme in interaction of bacterial immunoglobulin-binding proteins with immunoglobulins illustrated in the equine system [PDF]
, 2008 The M protein of Streptococcus equi subsp. equi known as fibrinogen-binding protein (FgBP) is a cell wall-associated protein with antiphagocytic activity that binds IgG. Recombinant versions of the seven equine IgG subclasses were used to investigate the
Abi-Rached +49 more
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