Results 41 to 50 of about 729,206 (315)
Complement Component C1q and Anti‐C1q Antibodies in Theory and in Clinical Practice [PDF]
Scandinavian Journal of Immunology, 2008 AbstractThe complement system is a major part of the innate immunity. The first component of the classical pathway of complement activation, C1q, plays a crucial role in the clearance of immune complexes and apoptotic bodies from the organism. Autoantibodies against C1q (anti‐C1q) have been found in a number of autoimmune and infectious diseases.
P. Kralikova, E. Potlukova
openaire +3 more sources
The role of complement component C1q in angiogenesis
Exploration of Immunology, 2023 The complement component C1q plays a role as a pro-angiogenic factor in different contexts, acting in a complement-independent way. For example, this molecule is able to foster the remodeling of the spiral arteries for a physiological pregnancy and to promote the wound healing process.
Mariagiulia Spazzapan +3 more
openaire +2 more sources
Hepatology, EarlyView., 2022 Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong +9 more
wiley +1 more source
Cerebral complement C1q activation in chronic Toxoplasma infection [PDF]
Brain, Behavior, and Immunity, 2016 Exposure to the neurotropic parasite, Toxoplasma gondii, causes significant brain and behavioral anomalies in humans and other mammals. Understanding the cellular mechanisms of T. gondii-generated brain pathologies would aid the advancement of novel strategies to reduce disease.
Jianchun Xiao +10 more
semanticscholar +4 more sources
Microglia mediate neurocognitive deficits by eliminating C1q-tagged synapses in sepsis-associated encephalopathy [PDF]
, 2023 Sepsis-associated encephalopathy (SAE) is a severe and frequent complication of sepsis causing delirium, coma, and long-term cognitive dysfunction. We identified microglia and C1q complement activation in hippocampal autopsy tissue of patients with ...
Andreas, Nico +23 more
core +1 more source
The peritumoral brain zone in glioblastoma: where we are and where we are going
Journal of Neuroscience Research, Volume 101, Issue 2, Page 199-216, February 2023., 2023 Abstract Glioblastoma (GBM) is the most aggressive and invasive primary brain tumor. Current therapies are not curative, and patients' outcomes remain poor with an overall survival of 20.9 months after surgery. The typical growing pattern of GBM develops by infiltrating the surrounding apparent normal brain tissue within which the recurrence is ...
Martina Giambra +8 more
wiley +1 more source
Complement in Renal Disease as a Potential Contributor to Arterial Hypertension
Kidney & Blood Pressure Research, 2021 Objective: Complement deposition is prevalent in kidney biopsies of patients with arterial hypertension and hypertensive nephropathy, but an association of hypertension and complement deposition or involvement of complement in the pathogenesis of ...
Lisa-Maren Fischer +6 more
doaj +1 more source
Frontiers in Immunology, 2020 To investigate the fine epitope(s) of anti-C1q A08 antibodies and their roles in complement activation in lupus nephritis, C1q A08 and related peptides with various amino acid sequences around A08 were synthesized.
Wen-Jun Wu +23 more
doaj +1 more source
TGF-β Signaling Regulates Neuronal C1q Expression and Developmental Synaptic Refinement [PDF]
, 2014 Immune molecules, including complement proteins C1q and C3, have emerged as critical mediators of synaptic refinement and plasticity. Complement localizes to synapses and refines the developing visual system via C3-dependent microglial phagocytosis of ...
Bialas, Allison R., Stevens, Beth
core +1 more source
Frontiers in Aging Neuroscience, 2022 BackgroundThe immune response and the complement system are associated with cognitive impairment and diabetes mellitus, respectively. Activation of the complement system in these diseases occurs mainly through either the classical pathway or the ...
Zhenxing Li +7 more
doaj +1 more source