Results 71 to 80 of about 375,488 (189)
Complement evasion factor (CEF), a novel immune evasion factor of Streptococcus pyogenes
Virulence, 2022 Streptococcus pyogenes, a leading human pathogen, is responsible for a wide range of diseases, including skin and soft tissue infections and severe invasive diseases. S.
Haniyeh Aghababa +5 more
doaj +1 more source
Glia, Volume 74, Issue 9, September 2026.Young adult deletion of microglial C1q reduced engulfment of Vglut1+ synapses and mitigated spatial cognitive deficits at 10 months of age in the amyloidopathy Arctic mouse model of AD. Neither fibrillar amyloid plaques nor soluble or insoluble Aβ levels in the hippocampus were affected by young adult microglial loss of C1q despite reduced phagocytosis
Tiffany J. Petrisko +4 more
wiley +1 more source
Intermodule cooperativity in the structure and dynamics of consecutive complement control modules in human C1r [PDF]
The FEBS Journal, 2010 The modular C1r protein is the first protease activated in the classical complement pathway, a key component of innate immunity. Activation of the heteropentameric C1 complex, possibly accompanied by major intersubunit re‐arrangements besides proteolytic cleavage, requires targeted regulation of flexibility within the context of the intramolecular and ...
András, Láng +5 more
openaire +2 more sources
Calcium-dependent conformational flexibility of a CUB domain controls activation of the complement serine protease C1r. [PDF]
, 2010 C1, the first component of the complement system, is a Ca(2+)-dependent heteropentamer complex of C1q and two modular serine proteases, C1r and C1s. Current functional models assume significant flexibility of the subcomponents.
Kardos, József +5 more
core +1 more source
, 2016 Complement component I (IF) and C1R subcomponent of Cl (C1R) types were determined by isoelectric focusing and subsequent immunoblotting techniques for 658 individuals from nine aboriginal Taiwanese populations.
Yuasa, Isao +7 more
core +1 more source
Scientific Reports, 2021 Endometriosis (EMS) is a disease that shows immune dysfunction and chronic inflammation characteristics, suggesting a role of complement system in its pathophysiology.
Liang Yu +6 more
doaj +1 more source
Andrology, Volume 14, Issue 6, Page 1535-1551, September 2026.ABSTRACT Background Oligoasthenozoospermia is a leading cause of male infertility and has been increasingly associated with the global surge in obesity and exposure to reproductive toxicants. Despite extensive research on each factor individually, their combined pathological effects remain poorly understood.
Yunlong Yao +12 more
wiley +1 more source
Cloning and sequencing of full-length cDNA encoding the precursor of human complement component C1r [PDF]
Biochemical Journal, 1986 The sequencing of human liver cDNA clones encoding the entire C1r precursor protein has confirmed the previously determined peptide sequence and has shown that there is a leader peptide which is 17 amino acids long. A residue tentatively identified as beta-hydroxyaspartic acid [Arlaud, Willis & Gagnon (1986) Biochem.
Journet, Agnès, Tosi, Mario
openaire +2 more sources
Frontiers in Immunology, 2020 C1-inhibitor (C1-INH) is an important regulator of the complement, coagulation, fibrinolytic and contact systems. The quantity of protease/C1-INH complexes in the blood is proportional to the level of the in vivo activation of these four cascade-like ...
Erika Kajdácsi +17 more
doaj +1 more source
Allergy, Volume 81, Issue 8, Page 2744-2774, August 2026.ABSTRACT Hereditary angioedema (HAE) with C1 inhibitor deficiency is a rare disease characterized by unpredictable episodes of tissue swelling (angioedema), which, in most cases, occur first under the age of 18 years, and entail a significant burden of disease not only for the patients but also for their families.
Henriette Farkas +128 more
wiley +1 more source