Results 81 to 90 of about 796,318 (197)
Proteomic characterization of thiazolidinedione regulation of obese adipose secretome in Zucker obese rats [PDF]
, 2009 Signaling molecules released by adipose tissue have been implicated in inflammation, adipocyte dysfunction and systemic insulin resistance. In this study, we used 2-D LC-MS/MS and quantitative proteomics approaches to characterize the obese adipose ...
Chen, Xiaoli +3 more
core +1 more source
Frontiers in Immunology, 2020 C1-inhibitor (C1-INH) is an important regulator of the complement, coagulation, fibrinolytic and contact systems. The quantity of protease/C1-INH complexes in the blood is proportional to the level of the in vivo activation of these four cascade-like ...
Erika Kajdácsi +17 more
doaj +1 more source
Scientific Reports, 2021 Endometriosis (EMS) is a disease that shows immune dysfunction and chronic inflammation characteristics, suggesting a role of complement system in its pathophysiology.
Liang Yu +6 more
doaj +1 more source
Effective Capacity in Multiple Access Channels with Arbitrary Inputs
, 2015 In this paper, we consider a two-user multiple access fading channel under quality-of-service (QoS) constraints. We initially formulate the transmission rates for both transmitters, where the transmitters have arbitrarily distributed input signals.
Akin, Sami +2 more
core +1 more source
Improved Sum-of-Squares Lower Bounds for Hidden Clique and Hidden Submatrix Problems [PDF]
, 2015 Given a large data matrix $A\in\mathbb{R}^{n\times n}$, we consider the problem of determining whether its entries are i.i.d. with some known marginal distribution $A_{ij}\sim P_0$, or instead $A$ contains a principal submatrix $A_{{\sf Q},{\sf Q ...
Deshpande, Yash, Montanari, Andrea
core
Data in Brief, 2016 This article provides kinetic constants for C-terminal processing of procollagen type I by bone morphogenetic protein 1 (BMP-1; the major procollagen C-proteinase), a reaction stimulated by the connective tissue glycoprotein procollagen C-proteinase ...
Laura Moschcovich, Efrat Kessler
doaj +1 more source
EMBO Molecular Medicine, 2023 Fibrosis is associated with compromised muscle functionality in Duchenne muscular dystrophy (DMD). We report observations with tissues from dystrophic patients and mice supporting a model to explain fibrosis in DMD, which relies on the crosstalk between ...
Francesca Florio +8 more
doaj +1 more source
Complement System Part I – Molecular Mechanisms of Activation and Regulation [PDF]
, 2015 Complement is a complex innate immune surveillance system, playing a key role in defense against pathogens and in host homeostasis. The complement system is initiated by conformational changes in recognition molecular complexes upon sensing danger ...
Lubka T. Roumenina +3 more
core +2 more sources
Intermodule cooperativity in the structure and dynamics of consecutive complement control modules in human C1r [PDF]
The FEBS Journal, 2010 The modular C1r protein is the first protease activated in the classical complement pathway, a key component of innate immunity. Activation of the heteropentameric C1 complex, possibly accompanied by major intersubunit re‐arrangements besides proteolytic cleavage, requires targeted regulation of flexibility within the context of the intramolecular and ...
András, Láng +5 more
openaire +2 more sources
Potential therapeutic benefit of C1-esterase inhibitor in neuromyelitis optica evaluated in vitro and in an experimental rat model. [PDF]
PLoS ONE, 2014 Neuromyelitis optica (NMO) is an autoimmune demyelinating disease of the central nervous system in which binding of anti-aquaporin-4 (AQP4) autoantibodies (NMO-IgG) to astrocytes causes complement-dependent cytotoxicity (CDC) and inflammation resulting ...
Lukmanee Tradtrantip +3 more
doaj +1 more source