Results 91 to 97 of about 2,792 (97)

Activation of the Classical Complement Pathway by Nephritic Factor Bound to the Alternative Pathway C3/C5 Convertase

The Journal of Immunology, 1979
Abstract Nephritic Factor (NF), the potent alternative pathway activator, which is occasionally found in association with certain types of nephritis has recently been identified as an IgG class autoantibody specific for the C3 convertase of the alternative pathway.
A T, Sobel, N R, Cooper, R D, Schreiber
openaire   +2 more sources

The C3/C5 convertase of the alternative pathway of complement: Stabilization and restriction of control by lanthanide ions

Molecular Immunology, 1983
The alternative pathway C3 convertase (C3b,Bb) is a Mg-dependent, labile enzyme with a t/2 of 3 min at 37 degrees C and of 14 min at 24 degrees C (at half physiological ionic strength). To stabilize the enzyme, metal ions of the lanthanide series were tested.
Z, Fishelson, H J, Müller-Eberhard
openaire   +2 more sources

A Novel Approach to Treatment of Paroxysmal Nocturnal Hemoglobinuria (PNH): Both Hemolysis and C3 Deposition Are Blocked by a Monoclonal Antibody (mAb) Specific for the Alternative Pathway of Complement (APC) C3/C5 Convertase.

Blood, 2009
Abstract Abstract 157 In PNH, red blood cells (RBCs) lack key complement control proteins, CD55 and CD59 and are therefore sensitive to complement activation and intravascular hemolysis. These regulatory proteins function at two different steps in the complement cascade; CD55 (decay accelerating factor, DAF) controls the ...
Ronald P Taylor, Margaret A Lindorfer, Andrew W Pawluczkowycz, Charles J Parker   +3 more
openaire   +1 more source

In situ assessment of glomerular C3/C5 convertases indicates ongoing complement activation in IgA nephropathy

Nephrology Dialysis Transplantation
ABSTRACT Background and hypothesis The complement system contributes to the progression of immunoglobulin A nephropathy (IgAN) and offers promising therapeutic targets currently under investigation. Identifying appropriate candidates for these treatments is now critical.
Augustin Obrecht, Marie-Sophie Meuleman, Jérôme Olagne, Anne Grunenwald, Sophie Chauvet, Lubka Roumenina, Véronique Frémeaux-Bacchi, Sophie Caillard, Anna Duval   +8 more
openaire   +1 more source

Trypanosoma lewisi: restriction of alternative complement pathway C3/C5 convertase activity.

Experimental parasitology, 1987
The rat parasite Trypanosoma lewisi was incubated in vitro with rat or human serum, washed, and extracted in detergent. Extracts were fractionated by electrophoresis in denaturing gels, transferred to nitrocellulose, allowed to renature, then immunoblotted with polyclonal antibodies to rat complement component C3 and human complement components C3, C5,
J E, Sturtevant, A E, Balber
openaire   +1 more source

Regulation of the C3 nephritic factor stabilized C3/C5 convertase of complement by purified human erythrocyte C3b receptor.

Clinical and experimental immunology, 1983
Activation of complement may result in the generation of the amplification convertase C3bBb. This convertase can be stabilized by properdin (P) or C3NeF. C3bBbP is susceptible to inactivation by beta 1H, while C3bBbNeF is relatively resistant. Since it has been shown that the human erythrocyte C3b receptor (CR1) is able to inactivate C3bBbP, the ...
M R, Daha, D J, Kok, L A, Van Es
openaire   +1 more source

Complement Component C2: the Classical and Lectin Pathway C3/C5 Convertases

2013
openaire   +1 more source