Results 71 to 80 of about 3,146 (147)

Dissecting the regions of virion-associated Kaposi's sarcoma-associated herpesvirus complement control protein required for complement regulation and cell binding

, 2006
Complement, which bridges innate and adaptive immune responses as well as humoral and cell-mediated immunity, is antiviral. Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a lytic cycle protein called KSHV complement control protein (KCP) that ...
Proctor, David Gwyn, Blom, Anna,, Aitken, J.A., Blom, AM, C. E. Blue, A. M. Blom, Blom, Anna M., Blue, C. E., Blom, Anna, L. Mark, D. J. Blackbourn, Mark, Linda,, O. B. Spiller, D. G. Proctor, Proctor, DG, Blackbourn, DJ, Blue, Clare, Blom, A.M., Spiller, Owen Bradley, Aitken, JA, Aikten, JA, Aitken, J. A., Blue, CE, Blackbourn, David J., Blackbourn, David, Spiller, OB, Mark, Linda, Blackbourn, D.J., Mark, CE, Mark, L, J. A. Aitken, Lund University.   +31 more
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Development of methods for analysis of ”C5 Nephritic Factors” (C5NeF)

, 2021
Normalt sett skyddar komplementsystemet kroppen mot infektioner och patogener. Vid vissa typer av njursjukdomar, framför allt vid C3-glomerulopati, förekommer autoantikroppar som kallas ”nephritic factors” (NeF).
Bäckström, Filippa
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Staphylococcal complement evasion by various convertase-blocking molecules.

, 2007
To combat the human immune response, bacteria should be able to divert the effectiveness of the complement system. We identify four potent complement inhibitors in Staphylococcus aureus that are part of a new immune evasion cluster. Two are homologues of
Maartje Ruyken, Köhl, J, Suzan H.M. Rooijakkers, Ruyken, M, Pandey, MK, Rooijakkers, SH, Jörg Köhl, Kok P.M. van Kessel, Jongerius, Ilse, Ilse Jongerius, Jongerius, I, van Strijp, JA, van Kessel, KP, Jos A.G. van Strijp, van Kessel, van, Manoj K. Pandey   +15 more
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Schematic representation of interactions between aggrecan G3 domain and complement.

, 2013
C1-complex binds the aggrecan G3 domain via the globular heads of C1q, which leads to activation of the classical pathway and the deposition of C4b.
Matthias Mörgelin (109607), Anders Aspberg (402464), Camilla Melin Fürst (402462), Kasper Vadstrup (402463), Dick Heinegård (55330), Anna M. Blom (53233)   +5 more
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Triple-fusion protein (TriFu) : a potent, targeted, enzyme-like inhibitor of all three complement activation pathways [PDF]

The introduction of a therapeutic anti-C5 antibody into clinical practice in 2007 inspired a surge into the development of complement-targeted therapies. This has led to the recent approval of a C3 inhibitory peptide, an antibody directed against C1s and
Sonnentag, Sophia J., Dopler, Arthur, Kleiner, Katharina, Späth, Nadja, Boyanapalli, Ruby, Akilah, Amira, Anliker, Markus, Schmidt, Christoph Q., Garg, Brijesh K., Schrezenmeier, Hubert, Höchsmann, Britta Elisabeth Hedwig, Huber-Lang, Markus, Mannes, Marco   +12 more
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A novel method for direct measurement of complement convertases activity in human serum

Complement convertases are enzymatic complexes that play a central role in sustaining and amplification of the complement cascade. Impairment of complement function leads directly or indirectly to pathological conditions, including higher infection rate,
Blom AM, Lopez-Trascasa M, Okroj M, Marchbank KJ, Berghard L, Volokhina EB, Stromberg P, van den Heuvel LP, Mollnes TE, Fransson V, Goodship TH, Viktorelius M   +11 more
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Molecular intercommunication between the complement and coagulation systems

, 2010
The complement system as well as the coagulation system has fundamental clinical implications in the context of life-threatening tissue injury and inflammation.
Lambris, J D, Daniel Rittirsch, Flierl, M A, Bo Nilsson, Markus Huber-Lang, Rittirsch, D, Klos, A, Rittirsch, Daniel, Barbara Acker, Amara, Umme, Uwe B. Brückner, Flierl, Michael A., Chen, Hui, Chen, H, Brueckner, Uwe B., Lambris, John D., Brückner, U B, Klos, Andreas, Umme Amara, Andreas Klos, Nilsson, Bo,, Michael A. Flierl, Hui Chen, Florian Gebhard, John D. Lambris, Amara, U, Gebhard, Florian, Acker, B, Nilsson, B, Gebhard, F, Huber-Lang, M, Acker, Barbara, Huber-Lang, Markus   +32 more
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Molecular insights into the surface-specific arrangement of complement C5 convertase enzymes

, 2015
Background: Complement is a large protein network in plasma that is crucial for human immune defenses and a major cause of aberrant inflammatory reactions.
Gorham R.D., Jr., Ruyken, M., Berends, E.T.M., Rooijakkers, S.H.M., Orhan, H., de Haas, C.J.C., Soppe, J.A., Aerts, P.C., Gros, P.   +8 more
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Correction: Sez6L2 inhibits complement by facilitating factor I cleavage of C3b and accelerating the decay of C3 convertases. [PDF]

Front Immunol
Qiu WQ, Luo S, Ma SA, Saminathan P, Li H, Gunnersen JM, Gelbard HA, Hammond JW.   +7 more
europepmc   +1 more source

A new perspective on the pathophysiology of kidney diseases: the intracellular complement system- "complosome". [PDF]

Front Nephrol
Leventoğlu E, Bakkaloğlu SA.
europepmc   +1 more source