Results 51 to 60 of about 610,146 (137)

Complement activation leads to C3 & C5 dependent prothrombotic alterations of fibrin clots

, 2019
Alterations of the fibrin network structure with thin fibrin fibers, increased fiber density, small pores, and hypofibrinolysis are associated with an increased risk of cardiovascular diseases.
Maxeiner, Sebastian
core   +1 more source

Effect of complement 3/5 knockout on renal proteomics landscape after ischemia and reperfusion injury in rats

Physiological Reports, Volume 14, Issue 14, July 2026.
Comparative proteomic analysis of kidneys from C3‐/‐ and C5‐/‐ rats following ischemia‐reperfusion injury (IRI) reveals diverse range of renal injury and repair mechanisms. C3 knockout enhanced mitochondrial, metabolic, and purine pathways while suppressing immune and extracellular matrix programs. In contrast, C5 absences affected extracellular matrix
Dinesh Bhattarai, Amod Sharma, Madison McGraw, Se‐Ran Jun, Neelam Joshi, Neriman Gokden, Samuel Mackintosh, Nirmala Parajuli   +7 more
wiley   +1 more source

Principles of novel complement convertase assay.

, 2013
Classical complement convertases are assembled on sheep erythrocytes sensitized with antibodies and incubated with C3 or C5-depleted serum. The lack of a particular component allows the complement cascade to proceed only to the stage of classical C3 ...
Ben C. King (303496), Marcin Okroj (90305), Emelie Holmquist (303495), Anna M. Blom (53233)   +3 more
core   +1 more source

The neuro‐immune interface in multiple sclerosis: From pathogenesis to therapeutic opportunities

Brain‐X, Volume 4, Issue 2, June 2026.
This review analyzes the immunopathology of multiple sclerosis (MS), focusing on the interactions between innate and adaptive immunity, glial cells, and key molecular mechanisms such as MHC, chemokines, cytokines, and the complement system. It also explores current and emerging therapeutic strategies, providing a comprehensive view of disease ...
Ruohan Wang, Mengqi Li, Xinyao Chen, Manling Lang, Qifei Cong   +4 more
wiley   +1 more source

Decoding the Factor H‐Related Proteins: Gatekeepers of Complement Dysregulation in AMD

European Journal of Immunology, Volume 56, Issue 6, June 2026.
This review will explore the role of the factor H‐related (FHR) proteins in age‐related macular degeneration (AMD), their accumulation in the outer blood/retinal barrier, and how they may contribute to barrier dysfunction and inflammation. ABSTRACT Age‐related macular degeneration (AMD) is the third most common form of blindness in the Western world ...
Jiaqi Tang, Nathalie Zgoda, Simon J. Clark   +2 more
wiley   +1 more source

A novel method for direct measurement of complement convertases activity in human serum

Complement convertases are enzymatic complexes that play a central role in sustaining and amplification of the complement cascade. Impairment of complement function leads directly or indirectly to pathological conditions, including higher infection rate,
Blom AM, Lopez-Trascasa M, Okroj M, Marchbank KJ, Berghard L, Volokhina EB, Stromberg P, van den Heuvel LP, Mollnes TE, Fransson V, Goodship TH, Viktorelius M   +11 more
core   +4 more sources

Iptacopan monotherapy resulted in increased hemoglobin level in patients with PNH and hemoglobin ≥10 g/dL after anti‐C5 therapy

HemaSphere, Volume 10, Issue 6, June 2026.
Abstract Patients with paroxysmal nocturnal hemoglobinuria (PNH) on anti‐C5 often experience extravascular hemolysis with anemia. Iptacopan, the first oral proximal complement inhibitor targeting factor B, has shown efficacy and safety in PNH patients. APPULSE‐PNH (NCT05630001), a phase 3b, single‑arm, open‐label trial, enrolled adult patients with PNH
Austin Kulasekararaj, Flore S. de Fontbrune, Anna Gaya, Ilene Weitz, David J. Kuter, Bhumika J. Patel, David J. Araten, Abhay Singh, Jun H. Jang, Richard J. Kelly, Eros Di Bona, Michael Loschi, Vinod Pullarkat, Jörg Schubert, Rosario Notaro, Mustafa N. Yenerel, Joan Beckman, Nicolas Blin, Irina Murakhovskaya, Jens Panse, Eloy Roman, Alexander Röth, Hubert Schrezenmeier, Srinivas Tantravahi, Régis P. de Latour, Navin Mahajan, Luca Monaco, Tao Ding, Tomasz Lawniczek, Philippe Ferber, Marion Dahlke, Antonio M. Risitano   +31 more
wiley   +1 more source

Multifaceted Role of Extracellular Vesicles: Intercellular Messengers to Therapeutic Applications: A Narrative Review

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Extracellular vesicles (EVs) are nanoscale carriers, including exosomes, microvesicles, and apoptotic bodies, that mediate intercellular communication by transporting proteins, nucleic acids, lipids, and metabolites. They regulate immunity, tissue repair, and cell differentiation.
Kajal Kamra, Satya Kumar Lalam, Shefali Srivastava, Madan Kumar Arumugam, Lokesh Kumar Boopathy, Simran Takkar, Zhiqiu Xia, Sabarinath Peruvemba Subramanian   +7 more
wiley   +1 more source

Current Status of Kidney Xenotransplantation in Basic Research

Organ Medicine, Volume 3, Issue 2, Page 87-101, June 2026.
Kidney xenotransplantation is a potential solution to the organ shortage for end‐stage kidney disease. This review systematically elaborates on the application advances of donor pig gene editing technologies, the molecular mechanisms and regulatory strategies of xenogeneic immune rejection, and the optimization approaches of immune compatibility ...
Yu Luo, Bingzhuo Liu, Weijie Lai
wiley   +1 more source

Urine Proteomic Profiling at Admission Reveals Complement Biomarkers Linked to Alcohol‐Associated Liver Disease

Alcohol, Clinical and Experimental Research, Volume 50, Issue 6, June 2026.
Patients with alcohol‐associated hepatitis (AH) and alcohol‐cirrhosis (AC) show perturbations in complement. Complement activation pathways are perturbed in the urine of patients with AH and AC, and distinguish severe AH from AC. Complement perturbations can help physicians and researchers to understand the liver–kidney crosstalk in severe AH and AC ...
Luan Prado, Ryan Musich, Moyinoluwa Taiwo, Vai Pathak, Daniel M. Rotroff, Annette Bellar, Nicole Welch, Jaividhya Dasarathy, David Streem, for the AlcHepNet, Srinivasan Dasarathy, Laura E. Nagy   +11 more
wiley   +1 more source