Results 51 to 60 of about 3,146 (147)

Structural Basis for the Function of Complement Component C4 within the Classical and Lectin Pathways of Complement [PDF]

, 2015
Complement component C4 is a central protein in the classical and lectin pathways within the complement system. During activation of complement, its major fragment C4b becomes covalently attached to the surface of pathogens and altered self-tissue, where
Szilágyi, Ágnes, Petersen, Steen V., Kidmose Rune T, Prohászka, Zoltan, Andersen Gregers R, Andersen, Gregers R., Kidmose, Rune T., Mortensen, Sofia, Mortensen Sofia,, Petersen Steen V   +9 more
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Yersinia enterocolitica O:3 Outer Membrane Vesicles as a Platform for Complement Activation

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
Basic characteristics and biological activity of outer membrane vesicles (OMVs) secreted by Yersinia enterocolitica O:3 (YeO3), depending on LPS chemotype and growth temperature. ABSTRACT Lipopolysaccharide (LPS) is the major component of the outer membrane vesicles (OMVs) of Gram‐negative bacteria.
Cédric Battaglino, Iryna Bodnaruk, Paula Czyszczoń, Mikael Skurnik, Beata Filip‐Psurska, Dariusz Jarych, Anna Maciejewska, Mariusz Gadzinowski, Kamil Malik, Izabela Potocka, Paweł Migdał, Roksana Kruszakin, Maciej Cedzyński, Katarzyna Kasperkiewicz, Jolanta Lukasiewicz, Anna S. Świerzko   +15 more
wiley   +1 more source

Identification of Key Genes Involved in Lactic Acid Metabolism in Periodontitis Based on Bioinformatics Analysis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 8, April 2026.
ABSTRACT Lactic acid metabolism correlates with periodontitis progression. Using machine learning (LASSO and SVM‐RFE) on GSE16134 and GSE173078 datasets, CFI and COQ2 were identified as key genes, with good diagnostic performance (AUC > 0.75). GSEA linked these genes to MAPK signalling, endocytosis, and ubiquitin‐mediated proteolysis.
Bijun Zhu, Shi Xu, Mingyue Cheng, Leiying Miao   +3 more
wiley   +1 more source

The Crystal Structure of Cobra Venom Factor, a Cofactor for C3- and C5-Convertase CVFBb

, 2009
SummaryCobra venom factor (CVF) is a functional analog of human complement component C3b, the active fragment of C3. Similar to C3b, in human and mammalian serum, CVF binds factor B, which is then cleaved by factor D, giving rise to the CVFBb complex ...
Narayana, Sthanam V.L., Xu, Yuanyuan, Karthe Ponnuraj, John E. Volanakis, Macon, Kevin, Ponnuraj, Karthe, Volanakis, John E., Sthanam V.L. Narayana, Krishnan, Vengadesan, Vengadesan Krishnan, Kevin Macon, Yuanyuan Xu   +11 more
core   +1 more source

Placenta‐derived extracellular vesicles: Signal messengers shuttling across the maternal‐fetal barrier

Interdisciplinary Medicine, Volume 4, Issue 2, March 2026.
In normal pregnancy, PEVs help maintain maternal–fetal immune tolerance while enabling controlled immune activation, promote endothelial migration, and support trophoblast invasion and syncytialization, strengthening antimicrobial defense. In pregnancy‐related disorders, dysregulated PEV signaling may drive endothelial dysfunction and hypertension, BBB
Jiale Du, Maliang Tao, Yanxuan Xiao, Zhijian Wang, Bo Situ, Lei Zheng   +5 more
wiley   +1 more source

Structural basis for the stabilization of the complement alternative pathway C3 convertase by properdin

, 2014
33 p.-4 fig.-2 fig. supl.Complement is an essential component of innate immunity. Its activation results in the assembly of unstable protease complexes, denominated C3/C5 convertases, leading to inflammation and lysis.
Llorca, Óscar, Rodríguez de Córdoba, Santiago, Tortajada, Agustín, Alcorlo, Martín   +3 more
core   +1 more source

The allosteric modulation of Complement C5 by knob domain peptides

, 2021
Bovines have evolved a subset of antibodies with ultra-long CDRH3 regions that harbour cysteine-rich knob domains. To produce high affinity peptides, we previously isolated autonomous 3-6 kDa knob domains from bovine antibodies.
Schulze, Monika-Sarah E.D., Alex Macpherson, Mollnes, Tom Eirik,, Tom Eirik Mollnes, Macpherson, Alex, Snowden, James, Oleinikovas, Vladas,, Schulze, Monika-Sarah Ed, Crennell, Susan, van den Elsen, Jean Mh, James Snowden, Ellis, Victoria,, Birtley, James R.,, Per H Nilsson, Svergun, Dmitri I., Dmitri Svergun, James R Birtley, Oleinikovas, Vladas, Lawson, Alastair D.G., Svergun, Dmitri,, Graewert, Melissa Ann, Deane, Charlotte M.,, van den Elsen, Jean M. H.,, Graewert, Melissa A.,, Jean MH van den Elsen, Nilsson, Per H., Maisem Laabei, Schulze, Monika-Sarah E. D.,, Mollnes, Tom Eirik, Ellis, Victoria, Melissa A Graewert, Robinson, Sarah A., Laabei, Maisem,, Graewert, Melissa A, Ben Holmes, Snowden, James,, Svergun, Dmitri, Holmes, Ben,, Nilsson, Per H.,, Deane, Charlotte M., Holmes, Ben, Victoria Ellis, Laabei, Maisem, Deane, Charlotte M, Susan Crennell, Monika-Sarah ED Schulze, Robinson, Sarah A.,, Birtley, James R, Ahdash, Zainab, Lawson, Alastair D. G.,, Robinson, Sarah A, Ahdash, Zainab,, Sarah A Robinson, Crennell, Susan,, Birtley, James R., Nilsson, Per H, Vladas Oleinikovas, Charlotte M Deane, Zainab Ahdash, Lawson, Alastair Dg, Alastair DG Lawson, Macpherson, Alex,, van den Elsen, Jean   +62 more
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Complement Hyperactivation Is Mediated by Alternative and Lectin Pathways During Early Phase of Severe Vaccination‐Omicron BA.5 Infection

Journal of Medical Virology, Volume 98, Issue 3, March 2026.
ABSTRACT Complement temporal activation kinetics, activation pathways, and their relationship with thromboinflammation and antibody responses in severe vaccination‐COVID‐19 remains unclear. Based on a vaccinated‐infected cohort, we analyzed complement immune responses across mild to critical COVID‐19 cases by a dynamic model.
Jinpeng Cao, Gang Yang, Tingting Cui, Jian Qin, Deyi Huang, Shiqin Jin, Xiaoyun Yang, Mingzhu Huang, Xiaoling Su, Siyi Liu, Yingjiao Xia, Shidong Deng, Chengna Luo, Zhuxiang Zhao, Yunhui Zhang, Nanshan Zhong, Zhongfang Wang   +16 more
wiley   +1 more source

The fc fragment of IgMs binds C1q to activate the first step of the classical complement pathway, while inhibiting complement‐dependent cytotoxicity

The FEBS Journal, Volume 293, Issue 5, Page 1358-1375, March 2026.
Multimeric IgM‐fragment crystallizable region (Fc) fragments retain the ability to bind C1q and initiate the classical complement pathway, leading to C4 activation and deposition in vitro. However, the Fc cores can also inhibit complement‐dependent cytotoxicity by competing with surface‐bound antibodies for C1q engagement.
Andrea J. Pinto, Anne Chouquet, Isabelle Bally, Véronique Rossi, Nicole M. Thielens, Chantal Dumestre‐Pérard, Renate Kunert, Christine Gaboriaud, Wai Li Ling, Jean‐Baptiste Reiser   +9 more
wiley   +1 more source

Complement C5 [PDF]

, 2012
Complement C5 is a 189 kDa protein synthesized in liver as a single-chain precursor molecule. The precursor molecule is then cleaved to a disulfide linked two-chain glycoprotein consisting of a 115 kDa (C5α) and a 75 kDa N-terminal (C5β) chain.
Dinasarapu, Ashok Reddy, Subramaniam, Shankar, Chandrasekhar, Anjana, Isenman, David E.   +3 more
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