Results 31 to 40 of about 3,146 (147)

The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection.

PLoS Pathogens, 2012
The complement system plays a key role in host defense against pneumococcal infection. Three different pathways, the classical, alternative and lectin pathways, mediate complement activation.
Youssif M Ali, Nicholas J Lynch, Kashif S Haleem, Teizo Fujita, Yuichi Endo, Soren Hansen, Uffe Holmskov, Kazue Takahashi, Gregory L Stahl, Thomas Dudler, Umakhanth V Girija, Russell Wallis, Aras Kadioglu, Cordula M Stover, Peter W Andrew, Wilhelm J Schwaeble   +15 more
doaj   +1 more source

Decoding the Factor H‐Related Proteins: Gatekeepers of Complement Dysregulation in AMD

European Journal of Immunology, Volume 56, Issue 6, June 2026.
This review will explore the role of the factor H‐related (FHR) proteins in age‐related macular degeneration (AMD), their accumulation in the outer blood/retinal barrier, and how they may contribute to barrier dysfunction and inflammation. ABSTRACT Age‐related macular degeneration (AMD) is the third most common form of blindness in the Western world ...
Jiaqi Tang, Nathalie Zgoda, Simon J. Clark   +2 more
wiley   +1 more source

C3 glomerulopathy — understanding a rare complement-driven renal disease

, 2019
The C3 glomerulopathies are a group of rare kidney diseases characterized by complement dysregulation occurring in the fluid phase and in the glomerular microenvironment, which results in prominent complement C3 deposition in kidney biopsy samples.
Nester, Carla M.,, D’Agati, Vivette D.,, Anna M. Blom, H. Terence Cook, Giuseppe Remuzzi, Mihály Józsi, Fremeaux-Bacchi, Véronique, Fremeaux-Bacchi, Véronique,, Sethi, Sanjeev,, Zipfel, Peter F., Blom, Anna M.,, Peter F. Zipfel, Pickering, Matthew C.,, Cook, H. Terence,, Van der Vlag, Johan,, Carla M. Nester, Smith, Richard J.H.,, Marina Noris, Johan Van der Vlag, Santiago Rodriguez de Córdoba, Noris, Marina,, Appel, Gerald B.,, de Córdoba, Santiago Rodriguez,, Zipfel, Peter F.,, de Córdoba, Santiago Rodriguez, Véronique Fremeaux-Bacchi, Lund University., Cook, H. Terence, Van der Vlag, Johan, Nester, Carla M., Gerald B. Appel, Appel, Gerald B., Sanjeev Sethi, Remuzzi, Giuseppe,, Smith, Richard J.H., Vivette D D’Agati, Richard J. H. Smith, Blom, Anna M., Lambris, John D.,, Fakhouri, Fadi, David Kavanagh, Fakhouri, Fadi,, Józsi, Mihály, Matthew C. Pickering, D’Agati, Vivette D., Sethi, Sanjeev, Lambris, John D., Remuzzi, Giuseppe, Pickering, Matthew C., Kavanagh, David,, Fadi Fakhouri, John D. Lambris, Kavanagh, David, Noris, Marina, Józsi, Mihály,   +54 more
core   +3 more sources

Iptacopan monotherapy resulted in increased hemoglobin level in patients with PNH and hemoglobin ≥10 g/dL after anti‐C5 therapy

HemaSphere, Volume 10, Issue 6, June 2026.
Abstract Patients with paroxysmal nocturnal hemoglobinuria (PNH) on anti‐C5 often experience extravascular hemolysis with anemia. Iptacopan, the first oral proximal complement inhibitor targeting factor B, has shown efficacy and safety in PNH patients. APPULSE‐PNH (NCT05630001), a phase 3b, single‑arm, open‐label trial, enrolled adult patients with PNH
Austin Kulasekararaj, Flore S. de Fontbrune, Anna Gaya, Ilene Weitz, David J. Kuter, Bhumika J. Patel, David J. Araten, Abhay Singh, Jun H. Jang, Richard J. Kelly, Eros Di Bona, Michael Loschi, Vinod Pullarkat, Jörg Schubert, Rosario Notaro, Mustafa N. Yenerel, Joan Beckman, Nicolas Blin, Irina Murakhovskaya, Jens Panse, Eloy Roman, Alexander Röth, Hubert Schrezenmeier, Srinivas Tantravahi, Régis P. de Latour, Navin Mahajan, Luca Monaco, Tao Ding, Tomasz Lawniczek, Philippe Ferber, Marion Dahlke, Antonio M. Risitano   +31 more
wiley   +1 more source

Validation of alternative convertases assays with acknowledged complement inhibitors.

, 2013
Alternative convertases were formed on the surface of rE with 5% of C5-depleted serum for 20 minutes in the presence (A) or absence (B) of complement inhibitors or control proteins.
Ben C. King (303496), Marcin Okroj (90305), Emelie Holmquist (303495), Anna M. Blom (53233)   +3 more
core   +1 more source

Complement C2 [PDF]

, 2013
Complement C2 is a single chain serum glycoprotein (110 kDa), which serves as the catalytic subunit of C3 and C5 convertases in the classical and lectin pathways.
Inal, Jameel, Dinasarapu, Ashok Reddy, Dinasarapu, Ashok Dinasarapu, Subramaniam, Shankar, Chandrasekhar, Anjana   +4 more
core   +1 more source

Multifaceted Role of Extracellular Vesicles: Intercellular Messengers to Therapeutic Applications: A Narrative Review

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Extracellular vesicles (EVs) are nanoscale carriers, including exosomes, microvesicles, and apoptotic bodies, that mediate intercellular communication by transporting proteins, nucleic acids, lipids, and metabolites. They regulate immunity, tissue repair, and cell differentiation.
Kajal Kamra, Satya Kumar Lalam, Shefali Srivastava, Madan Kumar Arumugam, Lokesh Kumar Boopathy, Simran Takkar, Zhiqiu Xia, Sabarinath Peruvemba Subramanian   +7 more
wiley   +1 more source

Properdin and factor H: Opposing players on the alternative complement pathway "see-saw" [PDF]

, 2013
This article has been made available through the Brunel Open Access Publishing Fund.Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway.
Kouser, L, Cordula M. Stover, Munirah Abdul-Aziz, Robert B. Sim, Nayak, A, Lubna Kouser, L. Kouser (7639589), Kishore, U, M. Abdul-Aziz (7677725), R. B. Sim (7584038), U. Kishore (7639601), Cordula M. Stover (7117046), Abdul-Aziz, M, Annapurna Nayak, A. Nayak (7334981), Stover, CM, Sim, RB, Uday Kishore   +17 more
core   +1 more source

Current Status of Kidney Xenotransplantation in Basic Research

Organ Medicine, Volume 3, Issue 2, Page 87-101, June 2026.
Kidney xenotransplantation is a potential solution to the organ shortage for end‐stage kidney disease. This review systematically elaborates on the application advances of donor pig gene editing technologies, the molecular mechanisms and regulatory strategies of xenogeneic immune rejection, and the optimization approaches of immune compatibility ...
Yu Luo, Bingzhuo Liu, Weijie Lai
wiley   +1 more source

C5 nephritic factors drive the biological phenotype of C3 glomerulopathies

, 2017
International audienceC3 Glomerulopathies, which include Dense Deposit Disease and C3 Glomerulonephritis, are associated with genetic and acquired dysregulation of the C3 convertase alternative pathway of complement.
Cailliez, Mathilde, Maria-Chiara Marinozzi, Pietrement, C., Marinozzi, M. C., Chauvet, S., Karras, A., Karras, Alexandre, Petitprez, F., Deschênes, Georges, Nobili, Francois, Veronique Fremeaux-Bacchi, Dragon-Durey, Marie-Agnès, Florent Petitprez, Mathilde Cailliez, Lubka T. Roumenina, Fakhouri, F., Roumenina, L. T., Michel Fischbach, Nobili, F., Alexandre Karras, Fakhouri, Fadi, Le Quintrec, M., Petitprez, Florent, Sophie Chauvet, Mignotet, M., Francois Nobili, Fischbach, M., Chauvet, Sophie, Christine Pietrement, Le Quintrec, Moglie, Frémeaux-Bacchi, Véronique, Marie-Agnes Dragon-Durey, Dragon-Durey, M. A., Fadi Fakhouri, Mignotet, Morgane, Legendre, Christophe, Moglie Le Quintrec, Marinozzi, Maria-Chiara, Georges Deschenes, Deschenes, G., Christophe Legendre, Roumenina, Lubka, Fremeaux-Bacchi, V., Pietrement, Christine, Morgane Mignotet, Cailliez, M., Fischbach, Michel, Legendre, C.   +47 more
core   +1 more source