Results 31 to 40 of about 610,146 (137)

Complement C3 and C5 deficiency affects fracture healing. [PDF]

, 2013
There is increasing evidence that complement may play a role in bone development. Our previous studies demonstrated that the key complement receptor C5aR was strongly expressed in the fracture callus not only by immune cells but also by bone cells and ...
Christian Ehrnthaller, Stefan Recknagel, Nilsson Per, Markus Huber-Lang, Per Nilsson, Mollnes Tom, Ronny Bindl, Redeker Simon, Rapp Anna, Ignatius Anita, Ignatius, Anita,, Anita Ignatius, Ehrnthaller Christian, Amling Michael, Anna Rapp, Nilsson, Per H.,, Tom Mollnes, Recknagel, Stefan,, Recknagel Stefan, Mollnes, Tom,, Simon Redeker, Gebhard Florian, Redeker, Simon,, Bindl, Ronny,, Huber-Lang Markus, Bindl Ronny, Ehrnthaller, Christian,, Florian Gebhard, Amling, Michael,, Rapp, Anna,, Gebhard, Florian,, Michael Amling, Huber-Lang, Markus,   +32 more
core   +1 more source

A novel and rapid method to purify the human complement opsonin C3b from human plasma

Frontiers in Immunology
Complement opsonin C3b is at the center of the complement cascade. All complement initiation pathways converge when convertases activate C3, converting it into the anaphylatoxin C3a and the opsonin C3b, which can attach to surfaces via its freshly ...
Jannik Sichau, Christoph Q. Schmidt
doaj   +1 more source

Decay accelerating factor (CD55) protects neuronal cells from chemical hypoxia-induced injury

Journal of Neuroinflammation, 2010
Background Activated complement system is known to mediate neuroinflammation and neurodegeneration following exposure to hypoxic-ischemic insults. Therefore, inhibition of the complement activation cascade may represent a potential therapeutic strategy ...
Tsokos George C, Simovic Milomir, Dalle Lucca Shawn L, Li Yansong, Wang Ying, Dalle Lucca Jurandir J   +5 more
doaj   +1 more source

Complement C3 [PDF]

, 2012
Complement C3 is the central component of the human complement system. It is ~186 kDa in size, consisting of an α-chain (~110 kDa) and a β-chain (~75 kDa) that are connected by cysteine bridges. C3 in its native form is inactive. Cleavage of C3 into C3b (
Dinasarapu, Ashok Reddy, Sahu, Arvind, Subramaniam, Shankar, Chandrasekhar, Anjana   +3 more
core   +1 more source

Venous Air Embolism Activates Complement C3 Without Corresponding C5 Activation and Trigger Thromboinflammation in Pigs [PDF]

, 2022
Introduction: Air embolism may complicate invasive medical procedures. Bubbles trigger complement C3-mediated cytokine release, coagulation, and platelet activation in vitro in human whole blood.
Nilsen, Bent Aksel, Ludviksen, Judith K, Christiansen, Dorte, Landsem, Anne, Mollnes, Tom Eirik, Fure, Hilde, Dybwik, Knut Gustav, Storm, Benjamin, Braaten, Tonje, Nielsen, Erik Waage, Pettersen, Kristin   +10 more
core   +1 more source

image_1_Functional Characterization of Alternative and Classical Pathway C3/C5 Convertase Activity and Inhibition Using Purified Models.tif

, 2018
Complement is essential for the protection against infections; however, dysregulation of complement activation can cause onset and progression of numerous inflammatory diseases.
Sanne Mol (5543531), Maartje Ruyken (3412181), Mihály Józsi (345845), Evelien T. M. Berends (5543534), Carla J. C. de Haas (176544), Seline A. Zwarthoff (5543528), Ronald D. Gorham (5398490), Suzan H. M. Rooijakkers (496562), Piet C. Aerts (5543537)   +8 more
core   +1 more source

The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection.

PLoS Pathogens, 2012
The complement system plays a key role in host defense against pneumococcal infection. Three different pathways, the classical, alternative and lectin pathways, mediate complement activation.
Youssif M Ali, Nicholas J Lynch, Kashif S Haleem, Teizo Fujita, Yuichi Endo, Soren Hansen, Uffe Holmskov, Kazue Takahashi, Gregory L Stahl, Thomas Dudler, Umakhanth V Girija, Russell Wallis, Aras Kadioglu, Cordula M Stover, Peter W Andrew, Wilhelm J Schwaeble   +15 more
doaj   +1 more source

Adaptive Immunity in Marsupials

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
Comparison of the marsupial and eutherian adaptive immune systems. ABSTRACT Marsupials diverged from eutherian mammals 125–160 million years ago. Although evolutionarily distinct, both groups of mammals can produce complex adaptive immune responses to antigens with several key differences.
Cassandra L. Jol, Hayley J. Stannard, Julie M. Old   +2 more
wiley   +1 more source

Breakthrough Hemolysis in Paroxysmal Nocturnal Hemoglobinuria: Mechanistic Insights and Management Strategies

Transfusion, EarlyView.
Abstract Background Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal hematopoietic stem cell disorder caused by somatic mutations in the PIGA gene, resulting in loss of glycosylphosphatidylinositol (GPI)‐anchored proteins, including the complement regulatory proteins, CD55 and CD59.
Ganesh Raman, Meghana Vivek, Rida Hasan, Siobán Keel, Laura Connelly‐Smith   +4 more
wiley   +1 more source

Xenotransplantation of the Porcine Lung—From Immunological Barriers to Emerging Experimental Strategies

Xenotransplantation, Volume 33, Issue 5, September/October 2026.
ABSTRACT Lung transplantation is the only long‐lasting life‐saving treatment for patients with end‐stage pulmonary disease, but the ever‐growing shortage of suitable donor organs leads to high mortality rates of the afflicted patients. Xenotransplantation, the transplantation of organs across species, has emerged as a promising alternative. This review
Nathalie Roters, Niveditha Varma, Robert Ramm, Heiner Niemann, Patrick Zardo, Arjang Ruhparwar, Tobias Goecke   +6 more
wiley   +1 more source