Results 21 to 30 of about 610,146 (137)

A potent truncated form of human soluble CR1 is protective in a mouse model of renal ischemia–reperfusion injury

Scientific Reports, 2021
The complement system is a potent mediator of ischemia–reperfusion injury (IRI), which detrimentally affects the function and survival of transplanted kidneys.
Anjan K. Bongoni, Ingela B. Vikstrom, Jennifer L. McRae, Evelyn J. Salvaris, Nella Fisicaro, Martin J. Pearse, Sandra Wymann, Tony Rowe, Adriana Baz Morelli, Matthew P. Hardy, Peter J. Cowan   +10 more
doaj   +1 more source

Borrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components [PDF]

, 2013
Spirochetes belonging to the Borrelia (B.) burgdorferi sensu lato complex differ in their resistance to complement-mediated killing, particularly in regard to human serum.
Christine Skerka, Skerka, Christine, Schwab, Jasmin, Peter Kraiczy (36173), Jasmin Schwab (105418), Christine Skerka (105424), Zipfel, Peter F., Richter, Dania, Peter Kraiczy, Peter F Zipfel, Dania Richter (105422), Franz-Rainer Matuschka, Peter F. Zipfel, Kraiczy, Peter, Reinhard Wallich (57833), Matuschka, Franz-Rainer, Dania Richter, Claudia Hammerschmidt, Wallich, Reinhard, Hammerschmidt, Claudia, Reinhard Wallich, Jasmin Schwab, Claudia Hammerschmidt (105420), Peter F. Zipfel (105431), Franz-Rainer Matuschka (105426)   +24 more
core   +1 more source

Mice lacking C1q or C3 show accelerated rejection of minor H disparate skin grafts and resistance to induction of tolerance [PDF]

, 2010
Complement activation is known to have deleterious effects on organ transplantation. On the other hand, the complement system is also known to have an important role in regulating immune responses.
Cook, T, Derbyshire, Katy, Dyson, Julian, Cook, Terence, Chai, JG, Coe, D, Scott, Diane, Dumitriu, IE, Baruah, Paramita, Coe, David, Dumitriu, Ingrid E; id_orcid, Dyson, J, Baruah, P, Derbyshire, K, Simpson, Elizabeth, Botto, Marina, Addey, C, Scott, D, Addey, Caroline, Botto, M, Chai, Jian-Guo, Simpson, E   +21 more
core   +1 more source

Complement ratios C3bc/C3 and sC5b-9/C5 do not increase the sensitivity of detecting acute complement activation systemically [PDF]

, 2021
Background Complement activation plays an important pathogenic role in numerous diseases. The ratio between an activation product and its parent protein is suggested to be more sensitive to detect complement activation than the activation product itself.
Nakstad, Espen Rostrup, Bosnes, Vidar, Pischke, Soeren, Andersen, Geir Øystein, Thomas, Anub Mathew, Barratt-Due, Andreas, Chaban, Viktoriia, Orrem, Hilde Lang, Sunde, Kjetil, Lundqvist, Christofer, Seljeflot, Ingebjørg, Schjalm, Camilla, Mollnes, Tom Eirik   +12 more
core   +2 more sources

Nephritic Factors: An Overview of Classification, Diagnostic Tools and Clinical Associations

Frontiers in Immunology, 2019
Nephritic factors comprise a heterogeneous group of autoantibodies against neoepitopes generated in the C3 and C5 convertases of the complement system, causing its dysregulation.
Fernando Corvillo, Fernando Corvillo, Marcin Okrój, Pilar Nozal, Pilar Nozal, Pilar Nozal, Marta Melgosa, Marta Melgosa, Pilar Sánchez-Corral, Pilar Sánchez-Corral, Margarita López-Trascasa, Margarita López-Trascasa   +11 more
doaj   +1 more source

Properdin Is a Key Player in Lysis of Red Blood Cells and Complement Activation on Endothelial Cells in Hemolytic Anemias Caused by Complement Dysregulation

Frontiers in Immunology, 2020
The complement system alternative pathway (AP) can be activated excessively in inflammatory diseases, particularly when there is defective complement regulation.
Jin Y. Chen, Neeti S. Galwankar, Heather N. Emch, Smrithi S. Menon, Claudio Cortes, Joshua M. Thurman, Samuel A. Merrill, Robert A. Brodsky, Viviana P. Ferreira   +8 more
doaj   +1 more source

C3 glomerulonephritis with genetically confirmed C3 deficiency in a pediatric patient: a case report [PDF]

Childhood Kidney Diseases
Complement component 3 glomerulonephritis (C3GN) is a rare kidney disease characterized by complement dysregulation that results in prominent complement component 3 (C3) deposition in the kidneys. The clinical course of C3GN varies from mild hematuria to
Hae Min Kim, Jae Il Shin, Ji Hong Kim, Jiyoung Oh, Ji-Man Kang, Hee Gyung Kang, Seong Heon Kim, Byoung Soo Cho, Keum Hwa Lee   +8 more
doaj   +1 more source

Ultrastructure of cobra venom factor-dependent C3/C5 convertase and its zymogen, factor B of human complement.

Journal of Biological Chemistry, 1982
The molecular architecture of the cobra venom factor (CVF)-dependent C3/C5 convertase (EC 3.4.21.47) of human complement was deduced from electron microscopy of the purified bimolecular complex (CVF,Bb) and its isolated subunits, CVF and Bb. Negatively stained CVF imaged as an irregularly shaped cylindrical structure, with approximate dimensions of 137
C A, Smith, C W, Vogel, H J, Müller-Eberhard   +2 more
openaire   +2 more sources

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

Complement system part I - molecular mechanisms of activation and regulation

Frontiers in Immunology, 2015
Complement is a complex innate immune surveillance system, playing a key role in defense against pathogens and in host homeostasis. The complement system is initiated by conformational changes in recognition molecular complexes upon sensing danger ...
Nicolas eMerle, Sarah Elizabeth Church, Veronique eFremeaux-Bacchi, Lubka T. Roumenina   +3 more
doaj   +1 more source