Results 41 to 50 of about 3,146 (147)
Alcohol, Clinical and Experimental Research, Volume 50, Issue 6, June 2026.Patients with alcohol‐associated hepatitis (AH) and alcohol‐cirrhosis (AC) show perturbations in complement. Complement activation pathways are perturbed in the urine of patients with AH and AC, and distinguish severe AH from AC. Complement perturbations can help physicians and researchers to understand the liver–kidney crosstalk in severe AH and AC ...
Luan Prado +11 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 11, Page 2874-2889, June 2026.Abstract Background and Purpose Overactivation of the alternative pathway (AP) underlies several diseases. Iptacopan is an oral, first‐in‐class, highly potent specific inhibitor of factor B, a key AP protease. Experimental Approach The analysis included data from two phase 1 randomised, volunteer‐blinded, placebo‐controlled studies: Study 1, a single ...
Irina Baltcheva +5 more
wiley +1 more source
, 2012 Complement C3 is the central component of the human complement system. It is ~186 kDa in size, consisting of an α-chain (~110 kDa) and a β-chain (~75 kDa) that are connected by cysteine bridges. C3 in its native form is inactive. Cleavage of C3 into C3b (
Dinasarapu, Ashok Reddy +3 more
core
Complement activation leads to C3 & C5 dependent prothrombotic alterations of fibrin clots
, 2019 Alterations of the fibrin network structure with thin fibrin fibers, increased fiber density, small pores, and hypofibrinolysis are associated with an increased risk of cardiovascular diseases.
Maxeiner, Sebastian
core +1 more source
Activation of the Lectin Pathway Drives Persistent Complement Dysregulation in Long COVID
Immunology, Volume 178, Issue 2, Page 261-268, June 2026.The complement cascade, a series of blood proteins that assists in the recognition and neutralisation of pathogens, either independently or in conjunction with antibodies, is persistently activated in patients with long COVID. We found that blood plasma samples from patients with long COVID contained elevated concentrations of the mannan‐binding lectin‐
Samuel B. K. Keat +14 more
wiley +1 more source
Principles of novel complement convertase assay.
, 2013 Classical complement convertases are assembled on sheep erythrocytes sensitized with antibodies and incubated with C3 or C5-depleted serum. The lack of a particular component allows the complement cascade to proceed only to the stage of classical C3 ...
Ben C. King (303496) +3 more
core +1 more source
Physiological Reports, Volume 14, Issue 11, June 2026.Abstract Ischemia‐reperfusion injury (IRI) is a prevalent condition that predominantly afflicts hospitalized patients, inducing acute kidney injury (AKI). In recent years, complement 5 (C5) and its anaphylatoxin receptor C5aR1 have been implicated in driving kidney IRI and loss of function.
Madison McGraw +5 more
wiley +1 more source
Staphylococcal complement inhibitor modulates phagocyte responses by dimerization of convertases.
, 2010 The human pathogen Staphylococcus aureus produces several complement-evasion molecules that enable the bacterium to withstand the host immune response. The human-specific staphylococcal complement inhibitor (SCIN) blocks the central C3 convertase enzymes
Jongerius, I +6 more
core +1 more source
Borrelia burgdorferi sensu lato Employs Several Escape Mechanisms to Bypass the Human Defense System
European Journal of Immunology, Volume 56, Issue 5, May 2026.Integrated overview of host defense and immune evasion in Lyme Borreliosis. Bbsl evades immunity through tick saliva‐mediated suppression of innate defenses, TLR2/NOD2‐driven cytokine dysregulation, and interference with JAK/STAT and CIITA‐dependent antigen presentation.
Zara Karami +2 more
wiley +1 more source
In situ Visualization of C3/C5 Convertases to Differentiate Complement Activation [PDF]
Kidney International Reports, 2020 Person, Fermin +9 more
openaire +2 more sources