Results 41 to 50 of about 610,146 (137)

Validation of alternative convertases assays with acknowledged complement inhibitors.

, 2013
Alternative convertases were formed on the surface of rE with 5% of C5-depleted serum for 20 minutes in the presence (A) or absence (B) of complement inhibitors or control proteins.
Ben C. King (303496), Marcin Okroj (90305), Emelie Holmquist (303495), Anna M. Blom (53233)   +3 more
core   +1 more source

The Role of Properdin in C5 Convertase Activity and C5b-9 Formation in the Complement Alternative Pathway

, 2021
Contains fulltext : 242823.pdf (Publisher’s version ) (Open Access)The complement system is an important part of innate immunity. Complement activation leads to formation of convertase enzymes, switch of their specificity from C3 to C5 ...
Heuvel, L.P.W.J. van den, Velden, T.J.A.M. van der, Kar, N.C.A.J. van de, Maas, R.J.F., Volokhina, E.B., Michels, M.A.H.M.   +5 more
core   +1 more source

Complement Inhibition in the Clinic: Are We Doing Enough to Protect Patients From Infection?

European Journal of Immunology, Volume 56, Issue 7, July 2026.
Excessive complement activation is implicated in a broad range of diseases. Therapeutic approaches targeting the complement cascade, from pathway‐selective inhibition to terminal blockade, can effectively control disease activity. However, increasing degrees of complement inhibition are associated with a heightened susceptibility to bacterial, viral ...
Serena Bettoni, Ebba Qviberg, Edward Chaloner, Hayley Lavender, Maisem Laabei   +4 more
wiley   +1 more source

The Crystal Structure of Cobra Venom Factor, a Cofactor for C3- and C5-Convertase CVFBb [PDF]

, 2009
SummaryCobra venom factor (CVF) is a functional analog of human complement component C3b, the active fragment of C3. Similar to C3b, in human and mammalian serum, CVF binds factor B, which is then cleaved by factor D, giving rise to the CVFBb complex ...
Narayana, Sthanam V.L., Xu, Yuanyuan, Karthe Ponnuraj, John E. Volanakis, Macon, Kevin, Ponnuraj, Karthe, Volanakis, John E., Sthanam V.L. Narayana, Krishnan, Vengadesan, Vengadesan Krishnan, Kevin Macon, Yuanyuan Xu   +11 more
core   +1 more source

Complement C2 [PDF]

, 2013
Complement C2 is a single chain serum glycoprotein (110 kDa), which serves as the catalytic subunit of C3 and C5 convertases in the classical and lectin pathways.
Inal, Jameel, Dinasarapu, Ashok Reddy, Dinasarapu, Ashok Dinasarapu, Subramaniam, Shankar, Chandrasekhar, Anjana   +4 more
core   +2 more sources

Properdin and factor H: Opposing players on the alternative complement pathway "see-saw" [PDF]

, 2013
This article has been made available through the Brunel Open Access Publishing Fund.Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway.
Kouser, L, Cordula M. Stover, Munirah Abdul-Aziz, Robert B. Sim, Nayak, A, Lubna Kouser, L. Kouser (7639589), Kishore, U, M. Abdul-Aziz (7677725), R. B. Sim (7584038), U. Kishore (7639601), Cordula M. Stover (7117046), Abdul-Aziz, M, Annapurna Nayak, A. Nayak (7334981), Stover, CM, Sim, RB, Uday Kishore   +17 more
core   +1 more source

C5 nephritic factors drive the biological phenotype of C3 glomerulopathies

, 2017
International audienceC3 Glomerulopathies, which include Dense Deposit Disease and C3 Glomerulonephritis, are associated with genetic and acquired dysregulation of the C3 convertase alternative pathway of complement.
Cailliez, Mathilde, Maria-Chiara Marinozzi, Pietrement, C., Marinozzi, M. C., Chauvet, S., Karras, A., Karras, Alexandre, Petitprez, F., Deschênes, Georges, Nobili, Francois, Veronique Fremeaux-Bacchi, Dragon-Durey, Marie-Agnès, Florent Petitprez, Mathilde Cailliez, Lubka T. Roumenina, Fakhouri, F., Roumenina, L. T., Michel Fischbach, Nobili, F., Alexandre Karras, Fakhouri, Fadi, Le Quintrec, M., Petitprez, Florent, Sophie Chauvet, Mignotet, M., Francois Nobili, Fischbach, M., Chauvet, Sophie, Christine Pietrement, Le Quintrec, Moglie, Frémeaux-Bacchi, Véronique, Marie-Agnes Dragon-Durey, Dragon-Durey, M. A., Fadi Fakhouri, Mignotet, Morgane, Legendre, Christophe, Moglie Le Quintrec, Marinozzi, Maria-Chiara, Georges Deschenes, Deschenes, G., Christophe Legendre, Roumenina, Lubka, Fremeaux-Bacchi, V., Pietrement, Christine, Morgane Mignotet, Cailliez, M., Fischbach, Michel, Legendre, C.   +47 more
core   +1 more source

Complement C3 mediates adolescent social isolation‐induced hippocampal synaptic deficits and sex‐specific emotional dysfunction

Interdisciplinary Medicine, Volume 4, Issue 4, July 2026.
Adolescent social isolation disrupts hippocampal function and exacerbates emotional symptoms, with sex‐specific patterns, as shown by human studies. In mice, social isolation decreased hippocampal synaptic density and calcium signaling, upregulated complement proteins, and activated complement‐mediated microglial synaptic phagocytosis.
Yuwan Qi, Siying Weng, Qiao Yin, Mengqi Li, Liang Shen, Enyou Qiao, Lu Gao, Yihan Wang, Yuxuan Li, Weifeng Luo, Qilin Zhang, Jing Wang, Jianfeng Feng, Qifei Cong   +13 more
wiley   +1 more source

In situ Visualization of C3/C5 Convertases to Differentiate Complement Activation [PDF]

Kidney International Reports, 2020
Person, Fermin, Petschull, Tim, Wulf, Sonia, Buescheck, Franziska, Biniaminov, Sergey, Fehrle, Wilfrid, Oh, Jun, Skerka, Christine, Zipfel, Peter F., Wiech, Thorsten   +9 more
openaire   +2 more sources

Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions

MedComm, Volume 7, Issue 7, July 2026.
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An, Yi An, Mengwei Chen, Longlong Wu, Rong Wang   +4 more
wiley   +1 more source