Results 61 to 70 of about 3,146 (147)

The Distribution of Complement Proteins in Soft and Hard Coronas Impacts Macrophage Uptake of Nanoparticles

Advanced Healthcare Materials, Volume 15, Issue 6, 9 February 2026.
Protein corona plays a critical role in the biological behavior of nanoparticles. This study investigates the distribution of complement proteins in soft corona and their impact on the macrophage uptake of polymer nanoparticles. It underlines the significance of soft corona investigation for understanding in vivo performance of nanomedicines.
Ying Qiu, Tianchang He, Chunjie Miao, Xinyang Shi, Yuanyuan Niu, Volker Mailänder, Daniel Crespy, Katharina Landfester, Shuai Jiang   +8 more
wiley   +1 more source

Complement factor C5 in Atlantic salmon (Salmo salar): characterization of cDNA, protein and glycosylation [PDF]

, 2019
Complement component 5 (C5) is an essential factor of the defensive complement system in all vertebrates. We report the characterization of C5 cDNA and protein from Atlantic salmon (Salmo salar), a teleost fish species of high importance in aquaculture ...
Johansen, Wenche, Moen, Anders, Agusti-Ridaura, Celia, Grove, Søren, Anonsen, Jan Haug, Strætkvern, Knut Olav, Azar, Amir Sefidmouy   +6 more
core   +1 more source

Serum properdin consumption as a biomarker of C5 convertase dysregulation in C3 glomerulopathy.

, 2016
Properdin (P) stabilizes the alternative pathway (AP) convertases, being the only known positive regulator of the complement system. In addition, P is a pattern recognition molecule able to initiate directly the AP on non-self surfaces.
Tortajada, A, Bravo García-Morato, M, Rodríguez de Córdoba, S, Corvillo, F, Garrido, S, López-Trascasa, M, Nozal, P   +6 more
core   +2 more sources

Kallikrein Cleaves C3 and Activates Complement

, 2017
The human plasma contact system is an immune surveillance system activated by the negatively charged surfaces of bacteria and fungi and includes the kallikrein-kinin, the coagulation, and the fibrinolytic systems.
Peter F. Zipfel, Sarah Irmscher, Niklas Beyersdorf, Christine Skerka, Luke D. Halder, Isabell Kopka, Shanshan Luo, Christine Dunker, Stefan Lorkowski, Nadia Döring, Ilse D. Jacobsen, Hortense Slevogt, Emeraldo A.H. Jo   +12 more
core   +1 more source

Tmax of classical convertases.

, 2013
EA were incubated with C3-depleted serum (A, C,) or C5-depleted serum (B, D) for indicated time periods and thereafter complement mediated lysis was developed with guinea-pig serum in a buffer containing EDTA, thus preventing de novo assembly of ...
Ben C. King (303496), Marcin Okroj (90305), Emelie Holmquist (303495), Anna M. Blom (53233)   +3 more
core   +1 more source

Paths reunited: initiation of the classical and lectin pathways of complement activation [PDF]

, 2010
Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago.
Schmid, Ralf, Schwaeble, Wilhelm J., Wilhelm J. Schwaeble, Anthony H. Keeble, Russell Wallis, Mitchell, Daniel A., Keeble, Anthony H., Wallis, Russell, Ralf Schmid, Daniel A. Mitchell   +9 more
core   +1 more source

Lessons from and for complement therapeutics: Novel mechanistic insights into terminal pathway activation and its linkage to thrombosis

In this cumulative dissertation, the precise mechanism of terminal pathway activation as well as the phenomenon of thromboembolic events in complement-related diseases have been elucidated.
Mannes, Marco
core   +1 more source

Complement deposition on pathogen and host surfaces.

, 2016
Saturation of pathogen surface is reached in 54 minutes with complement proteins such as C3b, iC3b, iC3bP (pathogen), C3dg, C3/C5 convertases, properdin (P*), MAC, and intermediates such as C3bB, C3bBP, C5b6-7, C5b6-8, and others.
Angel Dorado (2586817), Nehemiah Zewde (2586811), Dimitrios Morikis (108586), Ronald D. Gorham Jr. (2586814)   +3 more
core   +1 more source

Beyond lipids: Systemic effects of lipoprotein apheresis

Transfusion, Volume 66, Issue 3, Page 590-598, March 2026.
Menatalla Nadim, Yamac Akgun
wiley   +1 more source

Structural basis for therapeutic inhibition of complement C5.

, 2016
Activation of complement C5 generates the potent anaphylatoxin C5a and leads to pathogen lysis, inflammation and cell damage. The therapeutic potential of C5 inhibition has been demonstrated by eculizumab, one of the world's most expensive drugs. However,
Elmlund, H, Yang I Li, Johnson, S, Nunn, MA, Johnson, Steven, Jore, Matthijs M., Li, Yang I., Susan M Lea, Lea, SM, Natalie M Barber, Devon Sheppard, Lea, Susan M., Li, YI, Sheppard, Devon, Barber, Natalie M., Steven Johnson, Miles A Nunn, Matthijs M Jore, Barber, NM, Elmlund, Hans, Jore, MM, Nunn, Miles A., Sheppard, D, Hans Elmlund   +23 more
core   +1 more source