Results 11 to 20 of about 610,146 (137)

Functional Characterization of Alternative and Classical Pathway C3/C5 Convertase Activity and Inhibition Using Purified Models [PDF]

Frontiers in Immunology, 2018
Complement is essential for the protection against infections; however, dysregulation of complement activation can cause onset and progression of numerous inflammatory diseases.
Seline A. Zwarthoff, Evelien T. M. Berends, Sanne Mol, Maartje Ruyken, Piet C. Aerts, Mihály Józsi, Carla J. C. de Haas, Suzan H. M. Rooijakkers, Ronald D. Gorham   +8 more
doaj   +4 more sources

Complement Activation by Post-Translationally Modified Proteins: Links to Chronic Inflammation and Autoimmunity. [PDF]

Immunol Rev
ABSTRACT Post‐translational modifications (PTMs) of proteins are essential to maintain homeostasis as many cellular processes rely on reversible PTMs. However, several PTMs, particularly irreversible PTMs in the extracellular space, can contribute to tissue dysfunction, inflammation, and may even trigger the development of autoimmunity against PTM ...
van Greevenbroek MMJ, Trouw LA.
europepmc   +2 more sources

Complement Gene Variants Define the Conformational Dynamics of C3 Convertase. [PDF]

Eur J Immunol
Multidisciplinary data have significantly advanced our understanding of C3bBb molecular dynamics. This review specifically contextualizes the functional impact of disease‐associated genetic variants, demonstrating that clinical genetics not only supports the current C3bBb model but also provides novel insights into previously undefined molecular ...
Martín Merinero H, Welsh SJ, Xu Z, Smith RJH, Zhang Y.   +4 more
europepmc   +2 more sources

Complement Factor H-Based Therapeutics: A Comprehensive Overview. [PDF]

Eur J Immunol
Complement factor H is a central regulator of the complement system and thus a target for therapeutic intervention. In this review, we provide an overview of past and current factor H‐based therapeutic concepts and modalities to treat complement‐mediated diseases.
Hamers SMWR, Buter EJ, Pouw RB.
europepmc   +2 more sources

Different Aspects of Classical Pathway Overactivation in Patients With C3 Glomerulopathy and Immune Complex-Mediated Membranoproliferative Glomerulonephritis

Frontiers in Immunology, 2021
The rare and heterogeneous kidney disorder C3 glomerulopathy (C3G) is characterized by dysregulation of the alternative pathway (AP) of the complement system. C3G is often associated with autoantibodies stabilizing the AP C3 convertase named C3 nephritic
Marloes A. H. M. Michels, Nicole C. A. J. van de Kar, Sanne A. W. van Kraaij, Sebastian A. Sarlea, Valentina Gracchi, Flore A. P. T. Engels, Eiske M. Dorresteijn, Johannes van der Deure, Caroline Duineveld, Jack F. M. Wetzels, Lambertus P. W. J. van den Heuvel, Lambertus P. W. J. van den Heuvel, Lambertus P. W. J. van den Heuvel, Lambertus P. W. J. van den Heuvel, Elena B. Volokhina, Elena B. Volokhina   +15 more
doaj   +1 more source

Design and development of TT30, a novel C3d-targeted C3/C5 convertase inhibitor for treatment of human complement alternative pathway–mediated diseases [PDF]

Blood, 2011
AbstractTo selectively modulate human complement alternative pathway (CAP) activity implicated in a wide range of acute and chronic inflammatory conditions and to provide local cell surface and tissue-based inhibition of complement-induced damage, we developed TT30, a novel therapeutic fusion protein linking the human complement receptor type 2 (CR2 ...
Fridkis Hareli M, Storek M, Mazsaroff I, RISITANO, ANTONIO MARIA, Lundberg AS, Horvath CJ, Holers V.M.   +6 more
openaire   +3 more sources

Induction of immune cytolysis: tumor-cell killing by complement is initiated by covalent complex of monoclonal antibody and stable C3/C5 convertase. [PDF]

Proceedings of the National Academy of Sciences, 1981
The unique specificity of monoclonal antibodies (Ab) was combined with the cell-killing function of the cytolytic alternative pathway of complement. The functionally C3b-like glycoprotein of cobra venom was linked to a murine monoclonal Ab directed to a human melanoma-associated antigen by a disulfide bond, by using a heterobifunctional crosslinking ...
C W, Vogel, H J, Müller-Eberhard
openaire   +2 more sources

Aurin tricarboxylic acid protects against red blood cell hemolysis in patients with paroxysmal nocturnal hemoglobinemia. [PDF]

PLoS ONE, 2014
OBJECTIVES: Paroxysmal nocturnal hemoglobinemia (PNH) is a rare but serious condition characterized by complement-mediated red blood cell (RBC) hemolysis and episodic thrombotic attack.
Moonhee Lee, Sujaatha Narayanan, Edith G McGeer, Patrick L McGeer   +3 more
doaj   +1 more source

Deregulation of Factor H by Factor H-Related Protein 1 Depends on Sialylation of Host Surfaces

Frontiers in Immunology, 2021
To discriminate between self and non-self surfaces and facilitate immune surveillance, the complement system relies on the interplay between surface-directed activators and regulators.
Arthur Dopler, Selina Stibitzky, Rachel Hevey, Marco Mannes, Mara Guariento, Britta Höchsmann, Britta Höchsmann, Hubert Schrezenmeier, Hubert Schrezenmeier, Daniel Ricklin, Christoph Q. Schmidt   +10 more
doaj   +1 more source

Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b [PDF]

, 2012
Upon host infection, the human pathogenic microbe Staphylococcus aureus (S. aureus) immediately faces innate immune reactions such as the activated complement system. Here, a novel innate immune evasion strategy of S. aureus is described.
Peter F. Zipfel, Christine Skerka, Kraiczy, Peter, Michael Reuter, Reuter, Michael, Skerka, Christine, Barthel, Diana, Diana Barthel, Koch, Tina K., Elsen, Jean van den, Böhm, Sascha, Zipfel, Peter F., Jean van den Elsen, Peter Kraiczy, Tina K Koch, Sascha Böhm, Peter F Zipfel, Tina K. Koch   +17 more
core   +1 more source