Functional Characterization of Alternative and Classical Pathway C3/C5 Convertase Activity and Inhibition Using Purified Models [PDF]
Frontiers in Immunology, 2018 Complement is essential for the protection against infections; however, dysregulation of complement activation can cause onset and progression of numerous inflammatory diseases.
Seline A. Zwarthoff +8 more
doaj +4 more sources
C3-Glomerulopathy Autoantibodies Mediate Distinct Effects on Complement C3- and C5-Convertases [PDF]
Frontiers in Immunology, 2019 C3 glomerulopathy (C3G) is a severe kidney disease, which is caused by defective regulation of the alternative complement pathway. Disease pathogenesis is heterogeneous and is caused by both autoimmune and genetic factors.
Fei Zhao +13 more
doaj +2 more sources
A novel and rapid method to purify the human complement opsonin C3b from human plasma [PDF]
Frontiers in ImmunologyComplement opsonin C3b is at the center of the complement cascade. All complement initiation pathways converge when convertases activate C3, converting it into the anaphylatoxin C3a and the opsonin C3b, which can attach to surfaces via its freshly ...
Jannik Sichau, Christoph Q. Schmidt
doaj +2 more sources
C3 glomerulonephritis with genetically confirmed C3 deficiency in a pediatric patient: a case report [PDF]
Childhood Kidney DiseasesComplement component 3 glomerulonephritis (C3GN) is a rare kidney disease characterized by complement dysregulation that results in prominent complement component 3 (C3) deposition in the kidneys. The clinical course of C3GN varies from mild hematuria to
Hae Min Kim +8 more
doaj +2 more sources
Complement and transplant-associated thrombotic microangiopathy: Current and future approaches. [PDF]
HemasphereHemaSphere, Volume 10, Issue 4, April 2026.
Cugno M, Onida F, Lämmle B.
europepmc +2 more sources
Aurin tricarboxylic acid protects against red blood cell hemolysis in patients with paroxysmal nocturnal hemoglobinemia. [PDF]
PLoS ONE, 2014 OBJECTIVES: Paroxysmal nocturnal hemoglobinemia (PNH) is a rare but serious condition characterized by complement-mediated red blood cell (RBC) hemolysis and episodic thrombotic attack.
Moonhee Lee +3 more
doaj +1 more source
Induction of immune cytolysis: tumor-cell killing by complement is initiated by covalent complex of monoclonal antibody and stable C3/C5 convertase. [PDF]
Proceedings of the National Academy of Sciences, 1981 The unique specificity of monoclonal antibodies (Ab) was combined with the cell-killing function of the cytolytic alternative pathway of complement. The functionally C3b-like glycoprotein of cobra venom was linked to a murine monoclonal Ab directed to a human melanoma-associated antigen by a disulfide bond, by using a heterobifunctional crosslinking ...
C W, Vogel, H J, Müller-Eberhard
openaire +2 more sources
Adventitial Niches, Complement and Inflammation in Pulmonary Vascular Disease: Current Status and Future Directions. [PDF]
Compr PhysiolLocal complement production by pulmonary artery adventitial fibroblasts, activated intracellularly by CFD and CFB and extracellularly by GZMK+ CD8 T cells, and its secretion in soluble form and within EVs promotes macrophage and T cell chemotaxis and activation.
Zhang H +9 more
europepmc +2 more sources
Deregulation of Factor H by Factor H-Related Protein 1 Depends on Sialylation of Host Surfaces
Frontiers in Immunology, 2021 To discriminate between self and non-self surfaces and facilitate immune surveillance, the complement system relies on the interplay between surface-directed activators and regulators.
Arthur Dopler +10 more
doaj +1 more source
Scientific Reports, 2021 The complement system is a potent mediator of ischemia–reperfusion injury (IRI), which detrimentally affects the function and survival of transplanted kidneys.
Anjan K. Bongoni +10 more
doaj +1 more source