Results 41 to 50 of about 268,987 (334)

Anti-factor B autoantibody in dense deposit disease [PDF]

, 2010
Dense deposit disease (DDD), also known as membranoproliferative glomerulonephritis type II, is a rare kidney disorder that is associated with dysregulation of the alternative pathway of complement.
Józsi, Mihály, Papp, Krisztián, Prechl, József, Strobel, S., Zimmering, M.   +4 more
core   +1 more source

Generation of complement protein C3 deficient pigs by CRISPR/Cas9-mediated gene targeting

Scientific Reports, 2017
Complement protein C3 is the pivotal component of the complement system. Previous studies have demonstrated that C3 has implications in various human diseases and exerts profound functions under certain conditions.
Wei Zhang, Guan Wang, Ying Wang, Yong Jin, Lihua Zhao, Qiang Xiong, Lining Zhang, Lisha Mou, Rongfeng Li, Haiyuan Yang, Yifan Dai   +10 more
doaj   +1 more source

Complement Component C3 and Complement Factor B Promote Growth of Cutaneous Squamous Cell Carcinoma [PDF]

, 2017
Cutaneous squamous cell carcinoma (cSCC) is one of the most common metastatic skin cancers with increasing incidence. We examined the roles of complement component C3 and complement factor B (CFB) in the growth of cSCC. Analysis of cSCC cell lines (n = 8)
Farshchian, Mehdi, Grenman, Reidar, Heljasvaara, Ritva, Kahari, Veli-Matti, Kallajoki, Markku, Kivisaari, Atte, Meri, Seppo, Nissinen, Liisa, Peltonen, Juha, Peltonen, Sirkku, Pihlajaniemi, Taina, Riihila, Pilvi   +11 more
core   +1 more source

Bacterial infections in a pediatric cohort of primary and acquired complement deficiencies

Pediatric Rheumatology Online Journal, 2020
Background Acquired complement deficiency can occur in the setting of autoimmune syndromes, such as systemic lupus erythematosus (SLE), with very low or, occasionally, undetectable C3 levels.
Taha Al-Shaikhly, Kristen Hayward, Matthew L. Basiaga, Eric J. Allenspach   +3 more
doaj   +1 more source

Complement C3 and Nonalcoholic Fatty Liver Disease in Chronic Kidney Disease Patients: A Pilot Study

Kidney & Blood Pressure Research, 2020
Context: Evidences have suggested complement C3 is a biomarker for nonalcoholic fatty liver disease (NAFLD) in the general population. Objective: The present study was conducted to explore the predictive function of C3 for NAFLD in chronic kidney disease
Binbin Pan, Xin Wan, Mengqing Ma, Changchun Cao   +3 more
doaj   +1 more source

A Novel Homozygous In-Frame Deletion in Complement Factor 3 Underlies Early-Onset Autosomal Recessive Atypical Hemolytic Uremic Syndrome - Case Report

Frontiers in Immunology, 2021
Background and ObjectivesAtypical hemolytic uremic syndrome (aHUS) is mostly attributed to dysregulation of the alternative complement pathway (ACP) secondary to disease-causing variants in complement components or regulatory proteins.
Shirley Pollack, Shirley Pollack, Israel Eisenstein, Adi Mory, Tamar Paperna, Ayala Ofir, Hagit Baris-Feldman, Karin Weiss, Nóra Veszeli, Dorottya Csuka, Revital Shemer, Fabian Glaser, Zoltán Prohászka, Daniella Magen, Daniella Magen   +14 more
doaj   +1 more source

C3 glomerulonephritis with genetically confirmed C3 deficiency in a pediatric patient: a case report [PDF]

Childhood Kidney Diseases
Complement component 3 glomerulonephritis (C3GN) is a rare kidney disease characterized by complement dysregulation that results in prominent complement component 3 (C3) deposition in the kidneys. The clinical course of C3GN varies from mild hematuria to
Hae Min Kim, Jae Il Shin, Ji Hong Kim, Jiyoung Oh, Ji-Man Kang, Hee Gyung Kang, Seong Heon Kim, Byoung Soo Cho, Keum Hwa Lee   +8 more
doaj   +1 more source

Associations Between Complement Components and Vitamin D and the Physical Activities of Daily Living Among a Longevous Population in Hainan, China

Frontiers in Immunology, 2020
Background: Vitamin D and complement components shared some common pathophysiological pathways in the musculoskeletal system, circulation, and metabolism, which were linked to physical function.
Chi Zhang, Chi Zhang, Shihui Fu, Minghao Zhao, Deping Liu, Deping Liu, Yali Zhao, Yao Yao, Yao Yao   +8 more
doaj   +1 more source

Complement activation and its prognostic role in post-cardiac arrest patients [PDF]

, 2014
Cardiac arrest causes generalized ischemia/hypoxia, and subsequent resuscitation inflicts reperfusion injury, the pathology of which is not fully understood.
Bisschops, Bottiger, Cervera, Dunkelberger, Fust, Gombos, Gorsuch, Kohler, Lindsberg, Matsushita, Mocco, Oddo, Pedersen, Prohaszka, Shinozaki, Szeplaki, Turner, Wojtczak-Soska   +17 more
core   +1 more source

Platelet-bound complement (C3) in immune thrombocytopenia [PDF]

Blood, 1977
The fixation of complement to the circulating platelet in immune thrombocytopenia was detected by measurement of one of the complement components, C3, on the surface of platelets from patients with idiopathic thrombocytopenic purpura (ITP) and systemic lupus erythematosus (SLE) using the anti-C3 consumption assay.
T W, Hauch, W F, Rosse
openaire   +3 more sources