Results 41 to 50 of about 862,879 (325)
Терапевтический архив, 2023 Aim. To compare changes in the complement system in C3-glomerulopathy (C3-GP) and atypical hemolytic uremic syndrome (aHUS) after the relief of an acute episode of thrombotic microangiopathy. Materials and methods.
Valeriya A. Yurova +5 more
doaj +1 more source
Cell Research, 2019 Complement is known to play a role in alcoholic fatty liver disease (AFLD), but the underlying mechanisms are poorly understood, thereby constraining the development of a rational approach for therapeutic intervention in the complement system.
Fudi Zhong +18 more
semanticscholar +1 more source
Structural insights into the central complement component C3 [PDF]
Molecular Immunology, 2007 C3 is a central protein of the complement system, which is important to immune defense and provides a link between innate and adaptive immunity. Three pathways of complement activation converge at the activation of C3 yielding a diverse set of biological responses.
Janssen, B.J.C., Gros, P.
openaire +5 more sources
Generation of complement protein C3 deficient pigs by CRISPR/Cas9-mediated gene targeting
Scientific Reports, 2017 Complement protein C3 is the pivotal component of the complement system. Previous studies have demonstrated that C3 has implications in various human diseases and exerts profound functions under certain conditions.
Wei Zhang +10 more
doaj +1 more source
Bacterial infections in a pediatric cohort of primary and acquired complement deficiencies
Pediatric Rheumatology Online Journal, 2020 Background Acquired complement deficiency can occur in the setting of autoimmune syndromes, such as systemic lupus erythematosus (SLE), with very low or, occasionally, undetectable C3 levels.
Taha Al-Shaikhly +3 more
doaj +1 more source
bioRxiv, 2018 Dysregulation of the complement system is implicated in neurodegeneration, including human and animal glaucoma. Optic nerve and retinal damage in glaucoma is preceded by local complement upregulation and activation, but whether targeting this early ...
Alejandra Bosco +9 more
semanticscholar +1 more source
Eculizumab treatment: stochastic occurrence of C3 binding to individual PNH erythrocytes
Journal of Hematology & Oncology, 2017 Background C5 blockade by eculizumab prevents complement-mediated intravascular hemolysis in paroxysmal nocturnal hemoglobinuria (PNH). However, C3-bound PNH red blood cells (RBCs), arising in almost all treated patients, may undergo extravascular ...
Michela Sica +5 more
doaj +1 more source
Frontiers in Immunology, 2020 Background: Vitamin D and complement components shared some common pathophysiological pathways in the musculoskeletal system, circulation, and metabolism, which were linked to physical function.
Chi Zhang +8 more
doaj +1 more source
Cancer immunology research, 2018 Intracellular activation of complement C3 by tumor cells was found to suppress CD8+ T-cell responses by modulating tumor-associated macrophages. The data suggest that a combined strategy of PD-L1 blockade with C3 targeting may enhance antitumor immunity.
Haoran Zha +15 more
semanticscholar +1 more source
C3 glomerulonephritis with genetically confirmed C3 deficiency in a pediatric patient: a case report [PDF]
Childhood Kidney DiseasesComplement component 3 glomerulonephritis (C3GN) is a rare kidney disease characterized by complement dysregulation that results in prominent complement component 3 (C3) deposition in the kidneys. The clinical course of C3GN varies from mild hematuria to
Hae Min Kim +8 more
doaj +1 more source