Results 61 to 70 of about 976,787 (206)
Resistance to Streptozotocin-Induced Autoimmune Diabetes in Absence of Complement C3: Myeloid-Derived Suppressor Cells Play a Role. [PDF]
PLoS ONE, 2013 The contribution of complement to the development of autoimmune diabetes has been proposed recently. The underlying mechanisms, however, remain poorly understood.
Xiaogang Gao +3 more
doaj +1 more source
Cancer immunology research, 2018 Intracellular activation of complement C3 by tumor cells was found to suppress CD8+ T-cell responses by modulating tumor-associated macrophages. The data suggest that a combined strategy of PD-L1 blockade with C3 targeting may enhance antitumor immunity.
Haoran Zha +15 more
semanticscholar +1 more source
Complement Inactivation by Recombinant Human C3 Derivatives [PDF]
The Journal of Immunology, 2004 Abstract From the implications of the complement system in a large number of diseases, an urgent need for therapeutics effecting reduced complement activity in vivo has emerged. In this study we report the design of a novel class of enzymes of human origin that obliterate functional complement by a noninhibitory, catalytic mechanism ...
Johanna, Kölln +4 more
openaire +2 more sources
Complement component C3: A structural perspective and potential therapeutic implications
Seminars in Immunology, 2022 As the most abundant component of the complement system, C3 and its proteolytic derivatives serve essential roles in the function of all three complement pathways. Central to this is a network of protein-protein interactions made possible by the sequential proteolysis and far-reaching structural changes that accompany C3 activation.
Geisbrecht, Brian V. +2 more
openaire +3 more sources
Kidney Diseases Caused by Complement Dysregulation: Acquired, Inherited, and Still More to Come
Clinical and Developmental Immunology, 2012 Inherited and acquired dysregulation of the complement alternative pathway plays an important role in multiple renal diseases. In recent years, the identification of disease-causing mutations and genetic variants in complement regulatory proteins has ...
Saskia F. Heeringa, Clemens D. Cohen
doaj +1 more source
The complement C3 protein family in invertebrates [PDF]
Invertebrate Survival Journal, 2011 Complement C3 plays a pivotal role in the innate immune system of mammals as the central component of the complement system essential for its activation mechanism and effecter function.
M Nonaka
doaj +1 more source
Complement C3 Produced by Macrophages Promotes Renal Fibrosis via IL-17A Secretion
Frontiers in Immunology, 2018 Complement synthesis in cells of origin is strongly linked to the pathogenesis and progression of renal disease. Multiple studies have examined local C3 synthesis in renal disease and elucidated the contribution of local cellular sources, but the ...
Yanyan Liu +9 more
semanticscholar +1 more source
AJP - Renal Physiology, 2019 The impact of the renal microenvironment on macrophage phenotypes determination can contribute to the progression or resolution of renal fibrosis. While the complement proteins affect macrophage polarization, whether complement component 3 (C3) can ...
Jiong Cui +4 more
semanticscholar +1 more source
Clinical Chemistry, 2018 BACKGROUND Whether the complement system is involved in the development of diabetic microvascular disease is unknown. We tested the hypothesis that high concentrations of complement C3 are associated with increased risk of diabetic retinopathy ...
K. Rasmussen +2 more
semanticscholar +1 more source
Genomic organization of human complement component C3
Genomics, 1990 Six overlapping clones, spanning the entire C3 gene and the 5' flanking region, were isolated from two genomic lambda libraries. Thirty exons, covering the complete beta chain and part of the alpha chain as far as the C3d region, were analyzed.
K Y, Fong +3 more
openaire +2 more sources