Results 61 to 70 of about 268,987 (334)

Resistance to Streptozotocin-Induced Autoimmune Diabetes in Absence of Complement C3: Myeloid-Derived Suppressor Cells Play a Role. [PDF]

PLoS ONE, 2013
The contribution of complement to the development of autoimmune diabetes has been proposed recently. The underlying mechanisms, however, remain poorly understood.
Xiaogang Gao, Huanhai Liu, Bin He, Zhiren Fu   +3 more
doaj   +1 more source

Serum Soluble Mediator Signatures of Lupus Nephritis: Histologic Features and Response to Treatment

Arthritis Care &Research, EarlyView.
Objective Lupus nephritis (LN) management remains challenging, and novel noninvasive biomarkers are needed. This study quantified serum soluble mediators in the Accelerating Medicines Partnership (AMP) LN cohort to identify biomarkers of histologic features and treatment response.
Andrea Fava, Catriona A. Wagner, Carla J. Guthridge, Susan Macwana, Wade DeJager, Melissa E. Munroe, Peter Izmirly, H. Michael Belmont, Betty Diamond, Anne Davidson, Paul J. Utz, Michael H. Weisman, Philip M. Carlucci, Maria Dall'Era, Kenneth Kalunian, Chaim Putterman, Jennifer Anolik, Jennifer L. Barnas, David Wofsy, Diane Kamen, Richard A. Furie, Deepak A. Rao, the Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus Network, Chun‐Hao Lee, Derek Fine, Manny Monroy‐Trujillo, Ummara Shah, Mariko Ishimori, Robert M. Clancy, Michael Belmont, Ming Wu, Nicole Bornkamp, Evan Der, Beatrice Goilav, Nicole Jordan, Daniel Schwartz, James Pullman, David Wofsy, Dawn Smilek, Patti Tosta, Matthias Kretzler, Celine C. Berthier, E. Steve Woodle, Dave Hildeman, Michael Brenner, Michelle Petri, Joel M. Guthridge, Jill Buyon, Judith A. James   +48 more
wiley   +1 more source

Serological and genetic complement alterations in infection-induced and complement-mediated hemolytic uremic syndrome [PDF]

, 2016
Background: The role of complement in the atypical form of hemolytic uremic syndrome (aHUS) has been investigated extensively in recent years. As the HUS-associated bacteria Shiga-toxin-producing Escherichia coli (STEC) can evade the complement system ...
Bakker, J.A. (Jaap), Bouts, A.H. (Antonia), Dorresteijn, E.M. (Eiske), Goertz, J. (Joop), Gracchi, V. (Valentina), Heuvel, L.P. (Lambert) van den, Jeronimus-Klaasen, A. (Annelies), Kar, N.C. (Nicole) van de, Keijzer-Veen, M.G. (Mandy), Roos, A. (Anja), van der Molen, R.G. (Renate G.), van der Velden, T.J.A.M. (Thea J. A. M.), van Wijk, J.A.E. (Joanna A. E.), Volokhina, E.B. (Elena), Westra, D.F.   +14 more
core   +9 more sources

Analysis of Complement C3 Gene Reveals Susceptibility to Severe Preeclampsia [PDF]

, 2017
Preeclampsia (PE) is a common vascular disease of pregnancy with genetic predisposition. Dysregulation of the complement system has been implicated, but molecular mechanisms are incompletely understood.
Acedo, Andraweera, Barnes, Barrett, Best, Boij, Brest, Burwick, Chow, Cooper, Dai, Desmet, Eslami-Mossallam, Forneris, Gautier, Hoffman, Holmberg, Jamali, Janssen, Janssen, Jääskeläinen, Lee, Lillegard, Lokki, Lokki, Mancini, Mao, Meri, Nadeau-Vallee, Nakamura, Non-aka, Non-aka, Non-aka, Pihkala, Pijnenborg, Purcell, Purwar, Qaddourah, Quach, Reichhardt, Rhim, Roberts, Sabarinathan, Sabarinathan, Scheet, Silva, Staff, Stephens, Tang, Taniguchi-Sidle, Thomsen, Tsukamoto, Velickovic, Wan, Wu, Xu   +55 more
core   +1 more source

Complement Inactivation by Recombinant Human C3 Derivatives [PDF]

The Journal of Immunology, 2004
Abstract From the implications of the complement system in a large number of diseases, an urgent need for therapeutics effecting reduced complement activity in vivo has emerged. In this study we report the design of a novel class of enzymes of human origin that obliterate functional complement by a noninhibitory, catalytic mechanism ...
Johanna, Kölln, Edzard, Spillner, Jörg, Andrä, Katrin, Klensang, Reinhard, Bredehorst   +4 more
openaire   +2 more sources

Complement component C3: A structural perspective and potential therapeutic implications

Seminars in Immunology, 2022
As the most abundant component of the complement system, C3 and its proteolytic derivatives serve essential roles in the function of all three complement pathways. Central to this is a network of protein-protein interactions made possible by the sequential proteolysis and far-reaching structural changes that accompany C3 activation.
Geisbrecht, Brian V., Lambris, John D., Gros, Piet   +2 more
openaire   +3 more sources

Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous Belimumab in Pediatric Patients with Systemic Lupus Erythematosus: A Multicenter, Open‐Label Trial

Arthritis Care &Research, Accepted Article.
Objective This study aimed to characterize the pharmacokinetics, pharmacodynamics, safety, and exploratory efficacy of subcutaneous belimumab in pediatric patients with active systemic lupus erythematosus (SLE) receiving standard therapy. Methods This single‐arm, multicenter, open‐label trial (GSK study 200908; NCT04179032) used three‐weight‐band ...
Hermine I. Brunner, Jordi Antón, Inmaculada Calvo‐Penadés, Richard Dimelow, Gerd Horneff, Sylvia Kamphuis, Rebecca Marino, Andre van Maurik, Kirsten Minden, Masaaki Mori, Josephine Ocran‐Appiah, Christel Wilkinson, Yuichi Yamasaki, Deepak Assudani, for the Pediatric Rheumatology Collaborative Study Group (PRCSG) and Paediatric Rheumatology International Trials Organisation (PRINTO) network investigators   +14 more
wiley   +1 more source

Kidney Diseases Caused by Complement Dysregulation: Acquired, Inherited, and Still More to Come

Clinical and Developmental Immunology, 2012
Inherited and acquired dysregulation of the complement alternative pathway plays an important role in multiple renal diseases. In recent years, the identification of disease-causing mutations and genetic variants in complement regulatory proteins has ...
Saskia F. Heeringa, Clemens D. Cohen
doaj   +1 more source

Role of Prednisone and 25‐Hydroxyvitamin D on Bone Mineral Density and Osteoporosis in Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective We evaluated the role of 25‐hydroxyvitamin D (25[OH]D), prednisone, and other risk factors for bone mineral density (BMD) loss and osteoporosis in systemic lupus erythematosus (SLE). Methods We calculated the association between 25(OH)D levels and other potential risk factors and BMD measures (spine T scores) and osteoporosis (defined as a T ...
Nima Madanchi, Andrea Fava, Daniel W. Goldman, Laurence S. Magder, Michelle Petri   +4 more
wiley   +1 more source

The complement C3 protein family in invertebrates [PDF]

Invertebrate Survival Journal, 2011
Complement C3 plays a pivotal role in the innate immune system of mammals as the central component of the complement system essential for its activation mechanism and effecter function.
M Nonaka
doaj   +1 more source