Results 201 to 210 of about 400,071 (226)

Induction of platelet aggregation by the complement-derived peptides C3a and C5a

Naunyn-Schmiedeberg's Archives of Pharmacology, 1976
The effect of two complement-derived peptides, hog serum C3a and C5a, on platelet aggregation in platelet-rich plasma and suspensions in Tyrode solution was investigated. 1. Guinea-pig platelets were aggregated by both C3a and C5a; the spasmogenically inactive product of C3a, C3ai, also induced aggregation. Threshold concentrations were in the range of
C, Grossklaus, B, Damerau, E, Lemgo, W, Vogt   +3 more
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Comparative study on biological effects of the guinea pig complement-peptide C3a and C3a-related synthetic oligopeptides

Molecular Immunology, 1980
Dose-response experiments with guinea pig C3a and a synthetic hexapeptide (amino acid residues 72–77), representing the COOH-terminal sequence of human C3a, were performed in two recently described bioassay systems for C3a, i.e. cytotoxicity against tumor cells measured as LDH and 51Cr-release and non cytolytic serotonin release from guinea pig ...
D, Bitter-Suermann, S, Becker, S, Meuer, H U, Schorlemmer, U, Hadding, R, Andreatta   +5 more
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Complement component C3a or C3a desArg as a new marker for estimation of local vital reactions in incised skin wounds

Forensic Science International, 1992
The anaphylatoxin C3a or its desArg form (C3a/desArg) generated during complement activation could be detected in the vicinity of incised skin wounds of guinea pigs using immunoblotting methods. The C3a/desArg peptides were detectable immediately after injury in local sites up to 3 mm from the wound edge.
Y, Maeno, Y, Mori, M, Iwasa, H, Inoue, F, Takabe   +4 more
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Evaluation of complement system proteins C3a, C5a and C6 in patients of endometriosis

Clinical Biochemistry, 2020
Endometriosis is a disease that shows auto-immune and chronic characteristics, suggesting a role for proteins mediating immune interactions in its pathophysiology. The aim was to evaluate C3a and C5a for their role in inflammatory responses and C6 as the down-stream interactor following our previous findings on C5 mRNA expression changes in ...
Karadadas, Elif, Hortu, Ismet, Ak, Handan, Ergenoglu, Ahmet Mete, Karadadas, Nedim, Aydin, Hikmet Hakan   +5 more
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Complement C3a and C4a Increased in Plasma of Patients with Aspirin-induced Asthma

American Journal of Respiratory and Critical Care Medicine, 2006
Abstract Rationale Aspirin-induced asthma (AIA) is a distinct clinical syndrome that affects up to 10% of adults with asthma. Although eicosanoid metabolites appear to play an important role in AIA, the exact pathogenic mechanism for the syndrome remains obscure.
Seung-Ha, Lee, Taiyoun, Rhim, Yun-Sung, Choi, Ji-Won, Min, Sung-Ho, Kim, Sun-Young, Cho, Young-Ki, Paik, Choon-Sik, Park   +7 more
openaire   +2 more sources

Complement fragments C3a and C5a: The salt and pepper of the immune response

European Journal of Immunology, 2010
AbstractThe influence of complement on B‐cell responses has been known for many years, but the notion that T‐cell recognition, expansion and differentiation are complement dependent has only recently gained impetus. DC, and to a lesser extent T cells, produce a range of complement components necessary for complement activation, and these cells also ...
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Complexes of IgG molecules and C3a and C4a complement components in human serum

European Journal of Immunology, 1992
AbstractA heterogeneous group of proteins was separated from human serum IgG using 5 M guanidine hydrochloride solution in 0.1 M acetic acid. The protein mixture was fractionated by reverse‐phase high‐performance liquid chromatography and two proteins were isolated and identified as the C3a and C4a complement components (anaphylatoxins) according to ...
R, Nezlin, A, Freywald
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Complement C3a: Shaping the Plasticity of the Post-stroke Brain

2017
Complement is part of the innate immune system that plays a major role in the initiation of inflammation and host defence against pathogenic bacteria. Complement activation is also a contributor to tissue damage in a range of autoimmune conditions. For those reasons, the activation of the complement system in the central nervous system (CNS) was for ...
Anna Stokowska, Marcela Pekna
openaire   +1 more source

Complement anaphylatoxin C3a as a novel independent prognostic marker in heart failure

Clinical Research in Cardiology, 2012
The purpose of this study was to evaluate complement activation in a heart failure cohort. Based on their powerful biological activity, we hypothesized that the levels of anaphylatoxin C3a are related to pathological signs and outcomes in heart failure.Complement activation products C3a and SC5b9 were determined in 182 consecutive CHF patients (single ...
Gombos, Tímea, Förhécz, Zsolt, Pozsonyi, Zoltán, Széplaki, Gábor, Kunde Jan, Füst, György, Jánoskuti, Lívia, Karádi, István, Prohászka, Zoltán   +8 more
openaire   +3 more sources

Complement C3a-C3aR signaling in the colon epithelium 4117

The Journal of Immunology
Abstract Description   The liver-derived complement system has been considered the body’s main source for the complement cascade. Recently, complement C3 was found to be expressed in the gut under steady-state conditions and during inflammatory conditions.
Jaclyn A. Rivas, Crystal Madera Enriquez, Siem S. Goitom, Julie G. In, Eliseo F. Castillo   +4 more
openaire   +1 more source