Results 201 to 210 of about 26,149 (232)

Autoantibody-Mediated Complement C3a Receptor Activation Contributes to the Pathogenesis of Preeclampsia [PDF]

Hypertension, 2012
Preeclampsia (PE) is a prevalent life-threatening hypertensive disorder of pregnancy associated with increased complement activation. However, the causative factors and pathogenic role of increased complement activation in PE are largely unidentified.
Roxanna A Irani, Susan M Ramin
exaly   +5 more sources

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Selective Hexapeptide Agonists and Antagonists for Human Complement C3a Receptor

Journal of Medicinal Chemistry, 2010
Human anaphylatoxin C3a, formed through cleavage of complement protein C3, is a potent effector of innate immunity via activation of its G protein coupled receptor, human C3aR. Previously reported short peptide ligands for this receptor either have low potency or lack receptor selectivity.
Scully, Conor C. G., Blakeney, Jade S., Singh, Ranee, Hoang, Huy N., Abbenante, Giovanni, Reid, Robert C., Fairlie, David P.   +6 more
openaire   +5 more sources

Elevated complement C3a in plasma from patients with severe acute asthma [PDF]

Journal of Allergy and Clinical Immunology, 2003
Complement component C3a, an anaphylatoxin, provokes acute inflammatory responses, including smooth muscle contraction, mucus hypersecretion, increase in vascular permeability, and recruitment of inflammatory cells. Thus C3a may be related to airway inflammation and bronchoconstriction in acute asthma exacerbation.We sought to determine whether plasma ...
Yutaka, Nakano, Satoru, Morita, Akira, Kawamoto, Takahumi, Suda, Kingo, Chida, Hirotoshi, Nakamura   +5 more
exaly   +3 more sources

High Levels of Complement C3a Receptor in the Glomeruli in Lupus Nephritis

American Journal of Kidney Diseases, 2007
Taking into consideration the key role of the complement system in renal diseases, we investigated molecular and cellular properties of the human complement C3a receptor (C3aR) in vitro and in situ, looking at its expression in several human renal pathological states.Several antibodies were generated and used for immunohistochemistry and Western blot ...
Masashi Mizuno, Philippe Gasque
exaly   +3 more sources

Complement in asthma: sensitivity to activation and generation of C3a and C5a via the different complement pathways

Translational Research, 2006
Studies in rodent models suggested that complement may play a critical role in susceptibility to airway hyperresponsiveness (AHR) and as a mediator of bronchial obstruction and inflammation in asthma. Complement may participate in susceptibility to asthma because of an intrinsic abnormality in complement activation and generation of C3a, C5a, or other ...
Sven K, Wust, Malcolm N, Blumenthal, Edward O, Corazalla, Barbara A, Benson, Agustin P, Dalmasso   +4 more
openaire   +2 more sources

Evaluation of complement system proteins C3a, C5a and C6 in patients of endometriosis

Clinical Biochemistry, 2020
Endometriosis is a disease that shows auto-immune and chronic characteristics, suggesting a role for proteins mediating immune interactions in its pathophysiology. The aim was to evaluate C3a and C5a for their role in inflammatory responses and C6 as the down-stream interactor following our previous findings on C5 mRNA expression changes in ...
Karadadas, Elif, Hortu, Ismet, Ak, Handan, Ergenoglu, Ahmet Mete, Karadadas, Nedim, Aydin, Hikmet Hakan   +5 more
openaire   +3 more sources

Induction of platelet aggregation by the complement-derived peptides C3a and C5a

Naunyn-Schmiedeberg's Archives of Pharmacology, 1976
The effect of two complement-derived peptides, hog serum C3a and C5a, on platelet aggregation in platelet-rich plasma and suspensions in Tyrode solution was investigated. 1. Guinea-pig platelets were aggregated by both C3a and C5a; the spasmogenically inactive product of C3a, C3ai, also induced aggregation. Threshold concentrations were in the range of
C, Grossklaus, B, Damerau, E, Lemgo, W, Vogt   +3 more
openaire   +2 more sources

Detection of the C3a complement component in commercial gamma globulins by dot blotting

Journal of Immunological Methods, 1993
The C3a complement component (anaphylatoxin) was found in all studied samples of commercial gamma globulins. The corresponding monoclonal antibodies were used to detect C3a. It was shown that each gram of gamma globulin contained about 2-4 mg of bound C3a.
Roald Nezlin
exaly   +3 more sources

Comparative study on biological effects of the guinea pig complement-peptide C3a and C3a-related synthetic oligopeptides

Molecular Immunology, 1980
Dose-response experiments with guinea pig C3a and a synthetic hexapeptide (amino acid residues 72–77), representing the COOH-terminal sequence of human C3a, were performed in two recently described bioassay systems for C3a, i.e. cytotoxicity against tumor cells measured as LDH and 51Cr-release and non cytolytic serotonin release from guinea pig ...
D, Bitter-Suermann, S, Becker, S, Meuer, H U, Schorlemmer, U, Hadding, R, Andreatta   +5 more
openaire   +2 more sources

Complement factors C3a and C5a have distinct hemodynamic effects in the rat

International Immunopharmacology, 2009
In the rat, C5a infusion mediates well-defined effects including hypotension and neutropenia. Conversely, the comparative effect of C3a in the rat is not yet defined. In the current study, we have investigated C3a receptor (C3aR) activation in the rat, using recombinant human C3a, the C3aR agonist WWGKKYRASKLGLAR, which is a C-terminal analogue of C3a,
Lavinia M Proctor, Tyson A Moore, Peter N Monk   +2 more
exaly   +5 more sources