Results 191 to 200 of about 400,071 (226)

Serum complement system activation in normal healing and atrophic non-union of human long bone fractures. [PDF]

Front Immunol
El-Sherbiny YM, Ali YM, Jones E, Giannoudis PV, El-Jawhari JJ.   +4 more
europepmc   +1 more source

Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging. [PDF]

Nat Aging
Mishra M, Kim HH, Youm YH, Gonzalez-Hurtado E, Zaitsev K, Dlugos T, Shchukina I, Gliniak C, Ravussin E, Mohanty S, Shaw AC, Scherer PE, Artyomov MN, Dixit VD.   +13 more
europepmc   +1 more source

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Anti-analgesic and anti-amnesic effect of complement C3a

Life Sciences, 2000
In the present study, we found that complement C3a exerted central effects after intracerebroventricular administration in mice. At doses of 3 and 10 pmol/mouse, the peptide showed an antagonistic effect on analgesia induced by morphine and U-50488H, known to be mu- and kappa-opioid receptor agonists, respectively.
Masakatsu Takahashi, Masakazu Takahashi, Masaaki Yoshikawa   +2 more
exaly   +3 more sources

High Levels of Complement C3a Receptor in the Glomeruli in Lupus Nephritis

American Journal of Kidney Diseases, 2007
Taking into consideration the key role of the complement system in renal diseases, we investigated molecular and cellular properties of the human complement C3a receptor (C3aR) in vitro and in situ, looking at its expression in several human renal pathological states.Several antibodies were generated and used for immunohistochemistry and Western blot ...
Masashi Mizuno, Kazuhiro Nishikawa, Seiichi Matsuo   +2 more
exaly   +3 more sources

Detection of the C3a complement component in commercial gamma globulins by dot blotting

Journal of Immunological Methods, 1993
The C3a complement component (anaphylatoxin) was found in all studied samples of commercial gamma globulins. The corresponding monoclonal antibodies were used to detect C3a. It was shown that each gram of gamma globulin contained about 2-4 mg of bound C3a.
Roald Nezlin, R Nezlin
exaly   +3 more sources

Complement fragment C3a in plasma of asphyxiated neonates

European Journal of Pediatrics, 1992
Recent clinical studies with adult polytrauma patients indicate that elevated plasma levels of anaphylatoxin C3a correlate with the subsequent development of the adult respiratory distress syndrome (ARDS). However, there are no parameters which allow a reliable diagnosis of ARDS in neonates. As the most predisposing condition for ARDS seems to be shock,
L, Schrod, G, Frauendienst-Egger, H B, von Stockhausen, M, Kirschfink   +3 more
openaire   +2 more sources

Albutensin A and complement C3a decrease food intake in mice

Peptides, 2002
Albutensin A (Ala-Phe-Lys-Ala-Trp-Ala-Val-Ala-Arg) derived from serum albumin dose-dependently decreased food intake after intracerebroventricular (10-50 nmol/mouse) or peripheral (0.3-1.0 micromol/mouse) administration in fasted conscious ddY mice. Albutensin A delayed gastric emptying and elevated blood glucose levels.
Kousaku, Ohinata, Akio, Inui, Akihiro, Asakawa, Keiji, Wada, Etsuko, Wada, Masaaki, Yoshikawa   +5 more
openaire   +2 more sources

Selective Hexapeptide Agonists and Antagonists for Human Complement C3a Receptor

Journal of Medicinal Chemistry, 2010
Human anaphylatoxin C3a, formed through cleavage of complement protein C3, is a potent effector of innate immunity via activation of its G protein coupled receptor, human C3aR. Previously reported short peptide ligands for this receptor either have low potency or lack receptor selectivity.
Scully, Conor C. G., Blakeney, Jade S., Singh, Ranee, Hoang, Huy N., Abbenante, Giovanni, Reid, Robert C., Fairlie, David P.   +6 more
openaire   +5 more sources

Complement in asthma: sensitivity to activation and generation of C3a and C5a via the different complement pathways

Translational Research, 2006
Studies in rodent models suggested that complement may play a critical role in susceptibility to airway hyperresponsiveness (AHR) and as a mediator of bronchial obstruction and inflammation in asthma. Complement may participate in susceptibility to asthma because of an intrinsic abnormality in complement activation and generation of C3a, C5a, or other ...
Sven K, Wust, Malcolm N, Blumenthal, Edward O, Corazalla, Barbara A, Benson, Agustin P, Dalmasso   +4 more
openaire   +2 more sources

Osteoclast differentiation and formation induced by titanium implantation through complement C3a

Materials Science and Engineering: C, 2021
Titanium implantation is widely used for dental replacement with advantages of excellent mechanical strength, corrosion resistance, chemical stability and biocompatibility. Some patients, however, are subject to the failure of implantation due to bone resorption, which closely related to the inflammatory responses without clear mechanisms.
Xiaohan, Liu, Siwen, Li, Yuan, Meng, Yu, Fan, Jie, Liu, Ce, Shi, Feilong, Ren, Lin, Wu, Jinyan, Wang, Hongchen, Sun   +9 more
openaire   +2 more sources