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Urinary complement C3 fragment levels and their clinical relevance in MPO-ANCA-associated vasculitis. [PDF]
Sci RepHu Y +8 more
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Complement C3 and Activated Fragment C3a Are Involved in Complement Activation and Anti-Bacterial Immunity [PDF]
Frontiers in Immunology, 2022 In the complement system, C3 is a central component in complement activation, immune defense and immune regulation. In all pathways of complement activation, the pivotal step is conversion of the component C3 to C3b and C3a, which is responsible to eliminate the pathogen and opsonization.
Mo-Fei Li
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ELISA of complement C3a in bronchoalveolar lavage fluid
Journal of Immunological Methods, 1992Activated complement factors within the lung may induce several local biological effects. In order to investigate local complement activation we have developed non-competitive two-site ELISAs of C3a and total C3 in bronchoalveolar lavage fluid (BALF).
E A Van de Graaf, Henk M Jansen, T A Out
exaly +3 more sources
Anti-analgesic and anti-amnesic effect of complement C3a
Life Sciences, 2000In the present study, we found that complement C3a exerted central effects after intracerebroventricular administration in mice. At doses of 3 and 10 pmol/mouse, the peptide showed an antagonistic effect on analgesia induced by morphine and U-50488H, known to be mu- and kappa-opioid receptor agonists, respectively.
Masakatsu Takahashi
exaly +3 more sources
Involvement of complement peptides C3a and C5a in osteoarthritis pathology
Peptides, 2022Osteoarthritis (OA) affects more than 500 million people worldwide and is among the five diseases in Germany causing the highest suffering of the patients and cost for the society. The quality of life of OA patients is severely compromised, and adequate therapy is lacking owing to a knowledge gap that acts as a major barrier to finding safe and ...
Nicole, Schäfer, Susanne, Grässel
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The Role of Complement C3a Receptor in Stroke
NeuroMolecular Medicine, 2019The complement system is a key regulator of the innate immune response against diseased tissue that functions across multiple organ systems. Dysregulation of complement contributes to the pathogenesis of a number of neurological diseases including stroke.
Saif Ahmad +3 more
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Complement fragment C3a in plasma of asphyxiated neonates
European Journal of Pediatrics, 1992Recent clinical studies with adult polytrauma patients indicate that elevated plasma levels of anaphylatoxin C3a correlate with the subsequent development of the adult respiratory distress syndrome (ARDS). However, there are no parameters which allow a reliable diagnosis of ARDS in neonates. As the most predisposing condition for ARDS seems to be shock,
L, Schrod +3 more
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Potent Heterocyclic Ligands for Human Complement C3a Receptor
Journal of Medicinal Chemistry, 2014The G-protein coupled receptor (C3aR) for human inflammatory protein complement C3a is an important component of immune, inflammatory, and metabolic diseases. A flexible compound (N2-[(2,2-diphenylethoxy)acetyl]-l-arginine, 4), known as a weak C3aR antagonist (IC50 μM), was transformed here into potent agonists (EC50 nM) of human macrophages (Ca(2 ...
Reid, Robert C. +6 more
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Albutensin A and complement C3a decrease food intake in mice
Peptides, 2002Albutensin A (Ala-Phe-Lys-Ala-Trp-Ala-Val-Ala-Arg) derived from serum albumin dose-dependently decreased food intake after intracerebroventricular (10-50 nmol/mouse) or peripheral (0.3-1.0 micromol/mouse) administration in fasted conscious ddY mice. Albutensin A delayed gastric emptying and elevated blood glucose levels.
Kousaku, Ohinata +5 more
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