Results 71 to 80 of about 792,617 (213)

Implementation Punctuation: The Role of Feedback, Narratives, and Implementation in the Punctuated Equilibrium Theory

Policy Studies Journal, EarlyView.
ABSTRACT Based on the Punctuated Equilibrium Theory (PET) and implementation research, this study proposes an extended conceptualization of policy punctuation that enables researchers to systematically include policy implementation as part of a punctuation. The key mechanisms underlying the PET, i.e., policy image and venue, information processing, and
Bettina Stauffer
wiley   +1 more source

Proteomic Analysis of Golden Sputum Reveals Pulmonary Complement Activation During Acute Chest Syndrome in Children With Sickle Cell Disease

American Journal of Hematology, Volume 101, Issue 4, Page 678-686, April 2026.
ABSTRACT Acute chest syndrome (ACS) is one of the most common severe complications of sickle cell disease (SCD). In recent years, a major role of inflammation and innate immunity has been evidenced, but ACS pathophysiology remains incompletely understood, and therapeutic options are limited.
Slimane Allali, Nabiha Sbeih, Rachel Rignault‐Bricard, Johanna Bruce, Morgane Le Gall, Claire Heilbronner, Noemie de Cacqueray, Sofia Angyalosy, Melissa Taylor, Joséphine Brice, Mariane de Montalembert, Martina Bevacqua, Emilie‐Fleur Gautier, Olivier Hermine, Thiago Trovati Maciel   +14 more
wiley   +1 more source

Multiple activities of LigB potentiate virulence of Leptospira interrogans: inhibition of alternative and classical pathways of complement. [PDF]

PLoS ONE, 2012
Microbial pathogens acquire the immediate imperative to avoid or counteract the formidable defense of innate immunity as soon as they overcome the initial physical barriers of the host. Many have adopted the strategy of directly disrupting the complement
Henry A Choy
doaj   +1 more source

Selective Binding of Heparin/Heparan Sulfate Oligosaccharides to Factor H and Factor H-Related Proteins: Therapeutic Potential for C3 Glomerulopathies

Frontiers in Immunology, 2021
Complement dysregulation is characteristic of the renal diseases atypical hemolytic uremic syndrome (aHUS) and complement component 3 glomerulopathy (C3G).
Markus A. Loeven, Marissa L. Maciej-Hulme, Cansu Yanginlar, Melanie C. Hubers, Edwin Kellenbach, Mark de Graaf, Toin H. van Kuppevelt, Jack Wetzels, Ton J. Rabelink, Richard J. H. Smith, Johan van der Vlag   +10 more
doaj   +1 more source

Complement (C3b) interaction with the human granulocyte receptor: correlation of binding of fluid-phase radiolabeled ligand with histaminase release.

Journal of Immunology, 1982
The interaction of C3b, the major cleavage product of C3, with its receptor on human granulocytes results in important biological functions, including phagocytosis, superoxide generation, and release of a variety of enzymes, including histaminase.
J. Melamed, M. Arnaout, H. Colten
semanticscholar   +1 more source

CG001, a C3b-targeted complement inhibitor, blocks 3 complement pathways: development and preclinical evaluation

Blood Advances
Abstract Excessively activated or dysregulated complement activation may contribute to the pathogenesis of a wide range of human diseases, thus leading to a surge in complement inhibitors. Herein, we developed a human-derived and antibody-like C3b-targeted fusion protein (CRIg-FH-Fc) x2, termed CG001, that could ...
Ling Li, Peipei Ding, Yanrong Dong, Shupei Shen, Xinyue Lv, Jie Yu, Luying Li, Jianfeng Chen, Pilin Wang, Bing Han, Ting Xu, Weiguo Hu   +11 more
openaire   +2 more sources

THE INTERACTION OF ARENICIN-1 WITH C3B COMPLEMENT PROTEIN

Medical academic journal, 2019
The complement system and antimicrobial peptides (AMPs) are known to be vital humoral factors of innate immunity. Earlier we showed the double-sided influence of arenicin-1 (Ar-1), the AMP from a sea polychaeta Arenicola marina, on the complement activation.
E S Umnyakova, I A Krenev, S V Legkovoy, A V Sokolov, O N Rogacheva, T V Ovchinnikova, V N Kokryakov, M N Berlov   +7 more
openaire   +2 more sources

Complement Evasion byBorrelia burgdorferi: Serum-Resistant Strains Promote C3b Inactivation [PDF]

Infection and Immunity, 2001
ABSTRACTThe most characteristic features of the Lyme disease pathogens, theBorrelia burgdorferisensu lato (s.l.) group, are their ability to invade tissues and to circumvent the immune defenses of the host for extended periods of time, despite elevated levels of borrelia-specific antibodies in serum and other body fluids.
A, Alitalo, T, Meri, L, Rämö, T S, Jokiranta, T, Heikkilä, I J, Seppälä, J, Oksi, M, Viljanen, S, Meri   +8 more
openaire   +2 more sources

Silent Presentation, Significant Threat: Cold Agglutinin Syndrome After Haploidentical Hematopoietic Stem Cell Transplantation

eJHaem, Volume 7, Issue 2, April 2026.
This graphic abstract presents a comprehensive overview of cold agglutinin syndrome (CAS) following haploidentical hematopoietic stem cell transplantation (haplo‐HSCT) based on the content of our letter, including its clinical scenarios, potential triggers, pathophysiological mechanisms, clinical manifestations, as well as therapeutic and management ...
Zhuoyu An, Liqian Zhang, Peng Zhao, Yun He, Haixia Fu, Yuanyuan Zhang, Xiaodong Mo, Fengrong Wang, Chenhua Yan, Yuqian Sun, Meng Lv, Wei Han, Yuhong Chen, Yingjun Chang, Yu Wang, Lanping Xu, Xiangyu Zhao, Xiaojun Huang, Xiaohui Zhang   +18 more
wiley   +1 more source

Low‐Temperature Fabrication of Thymosin β4‐Loaded Soluble Microneedles to Promote Wound Healing by Specific Binding to Downregulated Immune Regulators Vsig4 and IL22rɑ2

Advanced Healthcare Materials, Volume 15, Issue 12, 25 March 2026.
Schematic diagram depicting the fabrication and application of thymosin β4 (Tβ4)‐loaded microneedle patches for wound treatment. The Tβ4 was loaded into chitosan (CS) and sucrose MNs under mild conditions (4°C, 65% relative humidity). The Tβ4 MN patch specifically binds to the downregulated immune regulators Vsig4 and IL22rα2, thereby accelerating ...
Shilong He, Mei Yuan, Changkang Feng, Yixuan Zhang, Jinjing Che   +4 more
wiley   +1 more source