Results 91 to 100 of about 14,451 (187)

Cellular Dynamics of Transgenic Porcine Endothelial Cells to Inflammatory Stimuli in Xenotransplantation Settings

Xenotransplantation, Volume 33, Issue 4, July/August 2026.
ABSTRACT Inflammatory responses have been shown to contribute significantly to the rejection of grafts in both allo‐ and xenotransplantation. In particular, they play a pivotal role in promoting endothelial activation, complement deposition, and thrombosis, thereby compromising the graft function.
Mitra Gultom, Nina Thomi, Kassandra Teixeira‐Riberio, Jane Shaw, Alain Despont, Nikolai Klymiuk, Elisabeth Kemter, Eckhard Wolf, Robert Rieben   +8 more
wiley   +1 more source

Effect of complement 3/5 knockout on renal proteomics landscape after ischemia and reperfusion injury in rats

Physiological Reports, Volume 14, Issue 14, July 2026.
Comparative proteomic analysis of kidneys from C3‐/‐ and C5‐/‐ rats following ischemia‐reperfusion injury (IRI) reveals diverse range of renal injury and repair mechanisms. C3 knockout enhanced mitochondrial, metabolic, and purine pathways while suppressing immune and extracellular matrix programs. In contrast, C5 absences affected extracellular matrix
Dinesh Bhattarai, Amod Sharma, Madison McGraw, Se‐Ran Jun, Neelam Joshi, Neriman Gokden, Samuel Mackintosh, Nirmala Parajuli   +7 more
wiley   +1 more source

Factor H interferes with the adhesion of sickle red cells to vascular endothelium: a novel disease-modulating molecule

Haematologica, 2019
Sickle cell disease is an autosomal recessive genetic red cell disorder with a worldwide distribution. Growing evidence suggests a possible involvement of complement activation in the severity of clinical complications of sickle cell disease.
Elisabetta Lombardi, Alessandro Matte, Antonio M. Risitano, Daniel Ricklin, John D. Lambris, Denise De Zanet, Sakari T. Jokiranta, Nicola Martinelli, Cinzia Scambi, Gianluca Salvagno, Zeno Bisoffi, Chiara Colato, Angela Siciliano, Oscar Bortolami, Mario Mazzuccato, Francesco Zorzi, Luigi De Marco, Lucia De Franceschi   +17 more
doaj   +1 more source

Immune evasion of Borrelia miyamotoi: CbiA, a novel outer surface protein exhibiting complement binding and inactivating properties

Scientific Reports, 2017
Borrelia (B.) miyamotoi, an emerging tick-borne relapsing fever spirochete, resists complement-mediated killing. To decipher the molecular principles of immune evasion, we sought to identify determinants contributing to complement resistance.
Florian Röttgerding, Alex Wagemakers, Joris Koetsveld, Volker Fingerle, Michael Kirschfink, Joppe W. Hovius, Peter F. Zipfel, Reinhard Wallich, Peter Kraiczy   +8 more
doaj   +1 more source

CG001, a C3b-targeted complement inhibitor, blocks 3 complement pathways: development and preclinical evaluation

Blood Advances
Abstract Excessively activated or dysregulated complement activation may contribute to the pathogenesis of a wide range of human diseases, thus leading to a surge in complement inhibitors. Herein, we developed a human-derived and antibody-like C3b-targeted fusion protein (CRIg-FH-Fc) x2, termed CG001, that could ...
Ling Li, Peipei Ding, Yanrong Dong, Shupei Shen, Xinyue Lv, Jie Yu, Luying Li, Jianfeng Chen, Pilin Wang, Bing Han, Ting Xu, Weiguo Hu   +11 more
openaire   +2 more sources

Complement C3b Measurement [PDF]

, 2020
openaire   +1 more source

A Revised Mechanism for the Activation of Complement C3 to C3b [PDF]

Journal of Biological Chemistry, 2015
Elizabeth Rodriguez, Ruodan Nan, Keying Li, Jayesh Gor, Stephen J. Perkins   +4 more
openaire   +1 more source

Factor H binding proteins protect division septa on encapsulated Streptococcus pneumoniae against complement C3b deposition and amplification. [PDF]

Nat Commun, 2018
Pathak A, Bergstrand J, Sender V, Spelmink L, Aschtgen MS, Muschiol S, Widengren J, Henriques-Normark B.   +7 more
europepmc   +1 more source

Correction: Sez6L2 inhibits complement by facilitating factor I cleavage of C3b and accelerating the decay of C3 convertases. [PDF]

Front Immunol
Qiu WQ, Luo S, Ma SA, Saminathan P, Li H, Gunnersen JM, Gelbard HA, Hammond JW.   +7 more
europepmc   +1 more source

Decoding the Factor H-Related Proteins: Gatekeepers of Complement Dysregulation in AMD. [PDF]

Eur J Immunol
Tang J, Zgoda N, Clark SJ.
europepmc   +1 more source