Facilitating crRNA Design by Integrating DNA Interaction Features of CRISPR‐Cas12a System
Advanced Science, EarlyView.This study introduces a novel approach combining molecular dynamics simulations and neural network modeling to predict the Cas12a trans‐cleavage activity. By integrating sequence and molecular interaction features, prediction accuracy is enhanced, and identify key features affecting Cas12a trans‐cleavage activity.
Zhihao Yao +7 more
wiley +1 more source
Evaluation of serum complement C4 among COVID-19 patients in Khartoum state: a case control-based study. [PDF]
F1000Res, 2023 Yahya M +3 more
europepmc +1 more source
Membrane Receptors for IgG and Complement (C4, C3b and C3d) on Human Eosinophils and Neutrophils and Their Relation to Eosinophilia [PDF]
, 1977 Azlinda Anwar, A. B. Kay
openalex +1 more source
Advanced Science, EarlyView.A novel SERS platform using gradient nanostructures and machine learning is presented. Gradient nanostructures minimize fabrication variability and enhance spectral diversity. The ML model significantly improves quantification precision, robustness and reproducibility, reducing test MSE by 84.8% and increasing R2 by 61.2%, enabling reliable real‐world ...
Xiaoyu Zhao +13 more
wiley +1 more source
Association between copy number variation of complement component
Journal of Biomedical Science, 2011 Background Gene copy number of complement component C4, which varies among individuals, may determine the intrinsic strength of the classical complement pathway.
Liao Wen-Ling +7 more
doaj +1 more source
Relevance of Complement C4 Deposits Localized to Distinct Vascular Compartments in ANCA-Associated Renal Vasculitis. [PDF]
Int J Mol Sci, 2022 Hakroush S +4 more
europepmc +1 more source
Activation of Complement by Endotoxin: A Role for γ2 Globulin, C1, C4 and C2 in the Consumption of Terminal Complement Components by Endotoxin-Coated Erythrocytes [PDF]
, 1972 J. K. Phillips +2 more
openalex +1 more source
Advanced Science, EarlyView.A cubic zinc‐based metal‐organic framework derived (Zn‐MOF‐derived) porous nitrogen‐doped carbon host is engineered to immobilize iodine, leveraging its hierarchical porosity and rich nitrogen sites to suppress polyiodide shuttling and enhance redox kinetics in zinc–iodine (Zn–I2) batteries.
Yong Li +8 more
wiley +1 more source
Alternative Complement Pathway Inhibition by Lampalizumab
Ophthalmology Science, 2023 Purpose: Lampalizumab, an antigen-binding fragment of a humanized monoclonal antibody directed against complement factor D (CFD), is designed to treat geographic atrophy (GA) secondary to age-related macular degeneration.
Rose Edmonds, MS +3 more
doaj
Plasma proteome changes associated with refractory cytopenia with multilineage dysplasia
Proteome Science, 2011 Background Refractory cytopenia with multilineage dysplasia (RCMD) is a subgroup of myelodysplastic syndrome (MDS), which belongs to oncohematological diseases, occurring particularly in elderly patients, and represents a heterogeneous group of bone ...
Čermák Jaroslav +4 more
doaj +1 more source