Complement C4 exacerbates astrocyte-mediated neuroinflammation and promotes α-synuclein pathology in Parkinson’s disease [PDF]
npj Parkinson's DiseaseComplement C4, implicated in neuroinflammation and synaptic dysfunction, plays a poorly defined role in Parkinson’s disease (PD). Here, we demonstrate elevated C4 levels in PD patient plasma and the substantia nigra of α-synuclein preformed fibril (α-syn
Wenkai Zou +6 more
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Effect of Low Complement C4 on Clinical Characteristics of Patients with First-Episode Neuromyelitis Optica Spectrum Disorder [PDF]
Neuropsychiatric Disease and Treatment, 2021 Chunyang Pan, Yi Zhao, Haojie Xie, Yongyan Zhou, Ranran Duan, Yanfei Li, Yanjie Jia, Tao Peng Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of ChinaCorrespondence: Tao PengDepartment of ...
Pan C +7 more
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Levels of complement C3 and C4 components in Amerindians living in an area with high prevalence of tuberculosis [PDF]
Memorias do Instituto Oswaldo Cruz, 2006 The levels of complement C3 and C4 components were determined in non-indigenous (creoles) and indigenous (Warao) populations, the latter with an extremely high tuberculosis (TB) rate.
Zaida Araujo +9 more
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Association of C4d with disease activity in anti-neutrophil cytoplasmic antibody-associated vasculitis: evidence for classical/lectin complement pathway activation [PDF]
Arthritis Research & TherapyBackground We aimed to investigate the involvement of the classical/lectin complement pathway in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) by exploring the complement activation fragment C4d in association to AAV activity ...
Anna Juto +8 more
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Increased activation product of complement 4 protein in plasma of individuals with schizophrenia
Translational Psychiatry, 2021 Structural variation in the complement 4 gene (C4) confers genetic risk for schizophrenia. The variation includes numbers of the increased C4A copy number, which predicts increased C4A mRNA expression.
Agnieszka Kalinowski +14 more
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Complement C4, C4A and C4a – What they do and how they differ [PDF]
Brain, Behavior, & Immunity - HealthMeike Heurich +2 more
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Frontiers in Immunology, 2020 Background: Vitamin D and complement components shared some common pathophysiological pathways in the musculoskeletal system, circulation, and metabolism, which were linked to physical function.
Chi Zhang +8 more
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TMC-1, the starless core sulfur factory: Discovery of NCS, HCCS, H2CCS, H2CCCS, and C4S and detection of C5S [PDF]
A&A 648, L3 (2021), 2021 We report the detection of the sulfur-bearing species NCS, HCCS, H2CCS, H2CCCS, and C4S for the first time in space. These molecules were found towards TMC-1 through the observation of several lines for each species. We also report the detection of C5S for the first time in a cold cloud through the observation of five lines in the 31-50 GHz range.
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Multi-mode excitation drives disorder during the ultrafast melting of a C4-symmetry-broken phase [PDF]
Nature Communications 13, 238 (2022), 2021 Spontaneous C4-symmetry breaking phases are ubiquitous in layered quantum materials, and often compete with other phases such as superconductivity. Preferential suppression of the symmetry broken phases by light has been used to explain non-equilibrium light induced superconductivity, metallicity, and the creation of metastable states.
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Determination of the chiral coupling constants c3 and c4 in new pp and np partial-wave analyses [PDF]
Phys.Rev. C67 (2003) 044001, 2003 As a first result of two new partial-wave analyses, one of the pp and another one of the np scattering data below 500 MeV, we report a study of the long-range chiral two-pion exchange interaction which contains the chiral coupling constants c1, c3, and c4.
arxiv +1 more source