Complement C4, Infections, and Autoimmune Diseases [PDF]
Frontiers in Immunology, 2021 Complement C4, a key molecule in the complement system that is one of chief constituents of innate immunity for immediate recognition and elimination of invading microbes, plays an essential role for the functions of both classical (CP) and lectin (LP ...
Hongbin Wang +3 more
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High plasma complement C4 levels as a novel predictor of clinical outcome in intracerebral hemorrhage [PDF]
Frontiers in Aging Neuroscience, 2023 ObjectiveThe complement cascade is activated and contributes to the brain injury after intracerebral hemorrhage (ICH). Complement component 4 (C4), an important component of complement cascade, has been associated with severity of neurological impairment
Moxin Wu +10 more
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Evaluation of serum complement C4 among COVID-19 patients in Khartoum state: a case control-based study [version 1; peer review: 2 approved] [PDF]
F1000Research, 2023 Background: The complement system is made up of an abundance of unique plasma proteins that play an important role in innate immunity and inflammation, aiding in the fight against pathogenic microbes and viral diseases.
Babbiker Mohammed Taher Gorish +3 more
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Effect of Low Complement C4 on Clinical Characteristics of Patients with First-Episode Neuromyelitis Optica Spectrum Disorder [PDF]
Neuropsychiatric Disease and Treatment, 2021 Chunyang Pan, Yi Zhao, Haojie Xie, Yongyan Zhou, Ranran Duan, Yanfei Li, Yanjie Jia, Tao Peng Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of ChinaCorrespondence: Tao PengDepartment of ...
Pan C +7 more
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Complement C4 exacerbates astrocyte-mediated neuroinflammation and promotes α-synuclein pathology in Parkinson’s disease [PDF]
npj Parkinson's DiseaseComplement C4, implicated in neuroinflammation and synaptic dysfunction, plays a poorly defined role in Parkinson’s disease (PD). Here, we demonstrate elevated C4 levels in PD patient plasma and the substantia nigra of α-synuclein preformed fibril (α-syn
Wenkai Zou +6 more
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Complement C4 Prevents Viral Infection through Capsid Inactivation. [PDF]
Cell Host Microbe, 2019 The complement system is vital for anti-microbial defense. In the classical pathway, pathogen-bound antibody recruits the C1 complex (C1qC1r2C1s2) that initiates a cleavage cascade involving C2, C3, C4, and C5 and triggering microbial clearance. We demonstrate a C4-dependent antiviral mechanism that is independent of downstream complement components ...
Bottermann M +15 more
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Associations of Serum Complement Biomarkers With Adverse Clinical Outcomes Among Patients With Ischemic Stroke [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground The complement system plays a crucial role in immune regulation and inflammatory response and is believed to be involved in the onset and progression of ischemic stroke.
Lulu Sun +11 more
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Low complement items play different roles on the classification performance of SLICC-2012, EULAR/ACR-2019, and SLERPI [PDF]
Frontiers in MedicineObjectivesThis study aimed to explore the association of low complement items with the performance of the systemic lupus erythematosus (SLE) classification criteria.MethodsThis study included 352 patients with SLE and 385 individuals with positive ...
Shanshan Chen +5 more
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Complement C4, C4A and C4a – What they do and how they differ [PDF]
Brain, Behavior, & Immunity - HealthMeike Heurich +2 more
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Journal of Marine Science and Engineering, 2023 In the evolution of the complement system, a major humoral innate immune factor, the existence of multiple isotypes of the complement components is considered as a key strategy to enhance innate immune defense. Complement C4 is also diversified in a wide
Rosli Nehlah +4 more
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