The complement component C4 of mammals [PDF]
Biochemical Journal, 1990 Human complement component C4 is coded by tandem genes located in the HLA class III region. The products of the two genes, C4A and C4B, are different in their activity. This difference is due to a degree of ‘substrate’ specificity in the covalent binding reactions of the two isotypes. Mouse also has a duplicated locus, but only one gene produces active
A W, Dodds, S K, Law
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Complement Activation in Patients With Probable Systemic Lupus Erythematosus and Ability to Predict Progression to American College of Rheumatology-Classified Systemic Lupus Erythematosus. [PDF]
, 2020 ObjectiveTo evaluate the frequency of cell-bound complement activation products (CB-CAPs) as a marker of complement activation in patients with suspected systemic lupus erythematosus (SLE) and the usefulness of this biomarker as a predictor of the ...
Alexander, Roberta Vezza +12 more
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Hepatitis C virus NS3/4A protease inhibits complement activation by cleaving complement component 4. [PDF]
PLoS ONE, 2013 BACKGROUND: It has been hypothesized that persistent hepatitis C virus (HCV) infection is mediated in part by viral proteins that abrogate the host immune response, including the complement system, but the precise mechanisms are not well understood.
Seiichi Mawatari +15 more
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Hypocomplementemia during tocilizumab treatment
Medicine, 2022 . Hypocomplementemia has been reported in patients with rheumatoid arthritis treated with tocilizumab (TCZ), but its long-term consequences are unknown.
Amir Bieber, MD +6 more
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Increased activation product of complement 4 protein in plasma of individuals with schizophrenia
Translational Psychiatry, 2021 Structural variation in the complement 4 gene (C4) confers genetic risk for schizophrenia. The variation includes numbers of the increased C4A copy number, which predicts increased C4A mRNA expression.
Agnieszka Kalinowski +14 more
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Frontiers in Immunology, 2020 Background: Vitamin D and complement components shared some common pathophysiological pathways in the musculoskeletal system, circulation, and metabolism, which were linked to physical function.
Chi Zhang +8 more
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Complementing antibody profiles: Assessing antibody function on antigen microarrays [PDF]
, 2012 Antibody effector functions other than neutralization depend on interactions with soluble and cellular components of the immune system. Antigen recognition is usually oligoclonal, with the different clones of antibodies belonging to different ...
Papp, Krisztián +2 more
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C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation [PDF]
, 2015 Complement C1q is the activator of the classical pathway. However, it is now recognized that C1q can exert functions unrelated to complement activation.
Agostinis, C +9 more
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Serological and Genetic Evidence for Altered Complement System Functionality in Systemic Lupus Erythematosus: Findings of the GAPAID Consortium. [PDF]
, 2016 Systemic lupus erythematosus is a chronic autoimmune disease with multifactorial ethiopathogenesis. The complement system is involved in both the early and late stages of disease development and organ damage.
Czirják, László +6 more
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Complement C4 allotypes and psoriasis.
Clinical Chemistry, 1989 Complement C4 allotypes were studied in a group of 100 patients with psoriasis vulgaria. Frequency of C4A and C4B allotypes in 46 randomly selected unrelated healthy subjects of the same ethnic origin, previously described, was taken as a control pattern.
Čvorišćec, Dubravka +2 more
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