Complement C4 - A Genetic Marker in Arthritides [PDF]
International Journal of Human Genetics, 2004 KEYWORDS Complement C4; juvenile arthritis; rheumatoid arthritis; osteo arthritis; phenotypes; arthritides ABSTRACT The present study aims at evaluating the role of complement C4 and its specific eletromorphic association with arthritides. C4 typing of the serum samples was carried out by PAGE on 41 juvenile arthritis, 101 rheumatoid arthritis, 25 ...
Ravi Babu, N. Pratibha, A. Padmini
openaire +1 more source
Rapid activation of the complement system by cuprophane depends on complement component C4 [PDF]
Kidney International, 1998 Hemodialysis with cuprophane dialyzer membranes promotes rapid activation of the complement system, which is thought to be mediated by the alternative pathway. Complete hereditary deficiency of complement C4, a classical pathway component, in two hemodialysis patients provided the opportunity to investigate a possible role of the classical pathway.
Karl Lhotta +4 more
openaire +3 more sources
Complementing antibody profiles: Assessing antibody function on antigen microarrays [PDF]
, 2012 Antibody effector functions other than neutralization depend on interactions with soluble and cellular components of the immune system. Antigen recognition is usually oligoclonal, with the different clones of antibodies belonging to different ...
Papp, Krisztián +2 more
core +1 more source
Definitions, 2020 Complement C4-B (1744 aa, ~193 kDa) is encoded by the human C4B and C4B_2 genes. This protein is involved in the propagation of the classical complement pathway.
semanticscholar +1 more source
Cutaneous vasculitis and recurrent infection caused by deficiency in complement factor I [PDF]
, 2018 Cutaneous leukocytoclastic vasculitis arises from immune complex deposition and dysregulated complement activation in small blood vessels. There are many causes, including dysregulated host response to infection, drug reactions, and various autoimmune ...
Despina Eleftheriou +9 more
core +2 more sources
C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation [PDF]
, 2015 Complement C1q is the activator of the classical pathway. However, it is now recognized that C1q can exert functions unrelated to complement activation.
Agostinis, C +9 more
core +2 more sources
Serological and Genetic Evidence for Altered Complement System Functionality in Systemic Lupus Erythematosus: Findings of the GAPAID Consortium. [PDF]
, 2016 Systemic lupus erythematosus is a chronic autoimmune disease with multifactorial ethiopathogenesis. The complement system is involved in both the early and late stages of disease development and organ damage.
Czirják, László +6 more
core +1 more source
Preferential association of hepatitis C virus with CD19+ B cells is mediated by complement system [PDF]
, 2016 Extrahepatic disease manifestations are common in chronic hepatitis C virus (HCV) infection. The mechanism of HCV-related lymphoproliferative disorders is not fully understood.
Alter, Harvey J. +7 more
core +1 more source
Health Science Reports, 2022 Purpose SARS‐CoV‐2 infection has spread in each corner of the world. Many health systems have dealt with it intensively. The complement system is an instrumental component in the inflammatory immune response and plays a role in the activation of blood ...
Ahmad Bagherimoghaddam +2 more
doaj +1 more source
Complement system biomarkers in first episode psychosis [PDF]
, 2019 Several lines of evidence implicate immunological/inflammatory factors in development of schizophrenia. Complement is a key driver of inflammation, and complement dysregulation causes pathology in many diseases.
Di Forti, Marta +8 more
core +2 more sources