Results 51 to 60 of about 942,109 (243)

Complement C4 - A Genetic Marker in Arthritides [PDF]

International Journal of Human Genetics, 2004
KEYWORDS Complement C4; juvenile arthritis; rheumatoid arthritis; osteo arthritis; phenotypes; arthritides ABSTRACT The present study aims at evaluating the role of complement C4 and its specific eletromorphic association with arthritides. C4 typing of the serum samples was carried out by PAGE on 41 juvenile arthritis, 101 rheumatoid arthritis, 25 ...
A. Padmini, Ravi Babu, N. Pratibha
openaire   +2 more sources

Genetically predicted complement component 4A expression: effects on memory function and middle temporal lobe activation [PDF]

, 2018
Background The longstanding association between the major histocompatibility complex (MHC) locus and schizophrenia (SZ) risk has recently been accounted for, partially, by structural variation at the complement component 4 (C4) gene.
A. Corvin, A. Richards, D. Cosgrove, D. Harold, D. Mothersill, D. W. Morris, G. Donohoe, J. Holland, K. Mantripragada, M. C. O'Donovan, M. Gill, M. J. Owen, null null, S. McCarthy-Jones   +13 more
core   +3 more sources

SALO, a novel classical pathway complement inhibitor from saliva of the sand fly Lutzomyia longipalpis. [PDF]

, 2016
Blood-feeding insects inject potent salivary components including complement inhibitors into their host's skin to acquire a blood meal. Sand fly saliva was shown to inhibit the classical pathway of complement; however, the molecular identity of the ...
Abdeladhim, M., Brandt, E.A., Collin, N., Coutinho-Abreu, I.V., Fazito Vale, V., Ferreira Mendes-Sousa, A., Ferreira, V.P., Gontijo, N.F., Horácio Pereira, M., Kamhawi, S., Kotsyfakis, M., Lima, K.F., Meneses, C., Nascimento Araújo, R., Oliveira, F., Pangburn, M.K., Rasouli, M., Ribeiro, J.M., Valenzuela, J.G.   +18 more
core   +1 more source

Effect of thiol compounds on human complement component C4 [PDF]

Biochemical Journal, 1993
Thiol compounds have been investigated as inhibitors of the covalent binding reaction of human complement protein C4 using Sepharose-C1s as a combined activating and binding surface. o- and p-substituted aminothiophenols are equally effective inhibitors, whereas the m-substituted compound is a less potent inhibitor. The anti-hypertensive drug captopril
Stuart Edmonds, A. Gibb, Edith Sim
openalex   +4 more sources

Serum complement levels in immune thrombocytopenia: Characterization and relation to clinical features

Research and Practice in Thrombosis and Haemostasis, 2020
Background Complement may contribute to platelet destruction in immune thrombocytopenia (ITP), but serum complement levels of ITP patients are not well defined. This study characterized C3, C4, and CH50 levels from 108 ITP patients in comparison with 120
Abraham Z. Cheloff, David J. Kuter, Hanny Al‐Samkari   +2 more
doaj   +1 more source

Macrophage-Derived Complement Component C4 Can Restore Humoral Immunity in C4-Deficient Mice [PDF]

The Journal of Immunology, 2002
Abstract Mice with a disrupted C4 locus (C4−/−) have an impaired immune response to thymus-dependent Ags. To test the role of bone marrow-derived C4 in humoral immunity, we reconstituted deficient animals with wild-type bone marrow or an enriched fraction of bone marrow-derived macrophages.
Mihaela, Gadjeva, Admar, Verschoor, Mark A, Brockman, Heather, Jezak, Li Ming, Shen, David M, Knipe, Michael C, Carroll   +6 more
openaire   +2 more sources

Cell-bound complement activation products associate with lupus severity in SLE

Lupus Science and Medicine, 2020
Objectives To evaluate the association between lupus severity and cell-bound complement activation products (CB-CAPs) or low complement proteins C3 and C4.Methods All subjects (n=495) fulfilled the American College of Rheumatology (ACR) classification ...
Richard A Furie, Daniel J Wallace, Judith A James, Susan Manzi, Amit Saxena, Rosalind Ramsey-Goldman, Chaim Putterman, John Conklin, Anca Askanase, Jill P Buyon, Elena Massarotti, Roberta Vezza Alexander, Sonali Narain, Cristina Arriens, Kenneth C Kalunian, Christopher E Collins, Ghalib A Bello, Joseph Ahearn   +17 more
doaj   +1 more source

Serum complements and immunoglobulin profiles in systemic lupus erythematosus patients: An observational study at a teaching hospital

Journal of Family Medicine and Primary Care, 2022
Context: Serum complement proteins and autoantibodies play an important role in the pathogenesis and diagnosis of systemic lupus erythematosus (SLE). Abnormalities in various immunoglobulin levels are described in patients of SLE.
Ranjan Singh Rana, Bitan Naik, Mahima Yadav, Usha Singh, Anup Singh, Shailja Singh   +5 more
doaj   +1 more source

A Molecular Switch Governs the Interaction between the Human Complement Protease C1s and Its Substrate, Complement C4*

Journal of Biological Chemistry, 2013
Background: In the classical pathway of the complement system, activated C1s cleaves C4. Results: C4 binding parameters and the crystal structure of CCP1-CCP2-SP of C1s zymogen are reported.
A. Perry, L. Wijeyewickrema, P. Wilmann, M. Gunzburg, L. D’Andrea, J. Irving, S. Pang, R. Duncan, J. Wilce, J. Whisstock, R. Pike   +10 more
semanticscholar   +1 more source

Structural Model for Factor X Inhibition of IgM and Complement-Mediated Neutralization of Adenovirus

Viruses, 2023
Adenovirus has strong therapeutic potential as an oncolytic virus and gene therapy vector. However, injecting human species C serotype 5 adenovirus, HAdv-C5, into the bloodstream leads to numerous interactions with plasma proteins that affect viral ...
Nicole Wagner, Dmitry M. Shayakhmetov, Phoebe L. Stewart   +2 more
doaj   +1 more source