Results 51 to 60 of about 905,894 (352)

SALO, a novel classical pathway complement inhibitor from saliva of the sand fly Lutzomyia longipalpis. [PDF]

, 2016
Blood-feeding insects inject potent salivary components including complement inhibitors into their host's skin to acquire a blood meal. Sand fly saliva was shown to inhibit the classical pathway of complement; however, the molecular identity of the ...
Abdeladhim, M., Brandt, E.A., Collin, N., Coutinho-Abreu, I.V., Fazito Vale, V., Ferreira Mendes-Sousa, A., Ferreira, V.P., Gontijo, N.F., Horácio Pereira, M., Kamhawi, S., Kotsyfakis, M., Lima, K.F., Meneses, C., Nascimento Araújo, R., Oliveira, F., Pangburn, M.K., Rasouli, M., Ribeiro, J.M., Valenzuela, J.G.   +18 more
core   +1 more source

Association of immune response with efficacy and safety outcomes in adults with phenylketonuria administered pegvaliase in phase 3 clinical trials [PDF]

, 2018
Background: This study assessed the immunogenicity of pegvaliase (recombinant Anabaena variabilis phenylalanine [Phe] ammonia lyase [PAL] conjugated with polyethylene glycol [PEG]) treatment in adults with phenylketonuria (PKU) and its impact on safety ...
Atkinson, John P, Boyer, Ryan, Gu, Zhonghu, Gupta, Soumi, Harding, Cary O, Knight, Vijaya, Larimore, Kevin, Lau, Kelly, Li, Mingjin, Olbertz, Joy, Rosen, Orli, Shepherd, Gillian, Shweighardt, Becky, Weng, Haoling H, Zoog, Stephen J   +14 more
core   +2 more sources

Cell-bound complement activation products associate with lupus severity in SLE

Lupus Science and Medicine, 2020
Objectives To evaluate the association between lupus severity and cell-bound complement activation products (CB-CAPs) or low complement proteins C3 and C4.Methods All subjects (n=495) fulfilled the American College of Rheumatology (ACR) classification ...
Richard A Furie, Daniel J Wallace, Judith A James, Susan Manzi, Amit Saxena, Rosalind Ramsey-Goldman, Chaim Putterman, John Conklin, Anca Askanase, Jill P Buyon, Elena Massarotti, Roberta Vezza Alexander, Sonali Narain, Cristina Arriens, Kenneth C Kalunian, Christopher E Collins, Ghalib A Bello, Joseph Ahearn   +17 more
doaj   +1 more source

Complement Activation Is Associated With Mortality in Patients With Necrotizing Soft-Tissue Infections—A Prospective Observational Study

Frontiers in Immunology, 2020
Aim: We assessed whether different complement factors and complement activation products were associated with poor outcome in patients with necrotizing soft-tissue infection (NSTI).Methods: We conducted a prospective, observational study in an intensive ...
Markus Korsholm Kristensen, Marco Bo Hansen, Marco Bo Hansen, Martin Bruun Madsen, Cecilie Bo Hansen, Katrine Pilely, Ole Hyldegaard, Ole Hyldegaard, Peter Garred   +8 more
doaj   +1 more source

A Molecular Switch Governs the Interaction between the Human Complement Protease C1s and Its Substrate, Complement C4*

Journal of Biological Chemistry, 2013
Background: In the classical pathway of the complement system, activated C1s cleaves C4. Results: C4 binding parameters and the crystal structure of CCP1-CCP2-SP of C1s zymogen are reported.
A. Perry, L. Wijeyewickrema, P. Wilmann, M. Gunzburg, L. D’Andrea, J. Irving, S. Pang, R. Duncan, J. Wilce, J. Whisstock, R. Pike   +10 more
semanticscholar   +1 more source

Immunoglobulins and complement factor C4 in adult rhinosinusitis

Clinical and Experimental Immunology, 2006
Summary We assessed whether complement and its factor C4 or abnormal immunoglobulin levels are associated with chronic or recurrent rhinosinusitis. We used multiple patient and control groups to obtain clinically meaningful data. Adult chronic or recurrent rhinosinusitis and acute purulent rhinosinusitis patients were compared with ...
Ilkka Seppälä, Olli Tahkokallio, Asko Järvinen, Seppo Meri, Irma-Leena Notkola, Mikko Seppänen, Hanna Jarva, Henrik Malmberg, Ville Valtonen, Jari Suvilehto, Jari Suvilehto, Marja-Liisa Lokki   +11 more
openaire   +4 more sources

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Genetically predicted complement component 4A expression: effects on memory function and middle temporal lobe activation [PDF]

, 2018
Background The longstanding association between the major histocompatibility complex (MHC) locus and schizophrenia (SZ) risk has recently been accounted for, partially, by structural variation at the complement component 4 (C4) gene.
A. Corvin, A. Richards, D. Cosgrove, D. Harold, D. Mothersill, D. W. Morris, G. Donohoe, J. Holland, K. Mantripragada, M. C. O'Donovan, M. Gill, M. J. Owen, null null, S. McCarthy-Jones   +13 more
core   +3 more sources

Evaluation of complement components C3 and C4 in serum of patient with neoplastic diseases

مجلة علوم ذي قار, 2019
The aim of this study is to evaluate the level of complement components C3 and C4 in serum of cancer patients to find which activation pathway of the complment system has the more effect in these cases .
Zeenah weheed Atwan, Shereen Jawad Al-Ali, Mohamed Abbas Mehdy   +2 more
doaj   +4 more sources

Serum complement levels in immune thrombocytopenia: Characterization and relation to clinical features

Research and Practice in Thrombosis and Haemostasis, 2020
Background Complement may contribute to platelet destruction in immune thrombocytopenia (ITP), but serum complement levels of ITP patients are not well defined. This study characterized C3, C4, and CH50 levels from 108 ITP patients in comparison with 120
Abraham Z. Cheloff, David J. Kuter, Hanny Al‐Samkari   +2 more
doaj   +1 more source