Results 151 to 160 of about 389,834 (185)

Human Complement Components C4A and C4B Genetic Diversities: Complex Genotypes and Phenotypes

Current Protocols in Immunology, 2005
AbstractThis unit describes methods that can accurately determine the genotypes and phenotypes of human complement components C4A and C4B. Specifically, they allow investigators to determine how many C4 genes are present in a diploid genome of a human subject and to quantify how many of them encode C4A proteins and how many of them encode C4B proteins.
Yee Ling Wu
exaly   +3 more sources

Rapid quantification of human complement component C4A and C4B genes by capillary gel electrophoresis

Electrophoresis, 2006
AbstractComplement component 4 (C4) is an important plasma protein playing a major role in the human defense mechanism against infectious diseases and inflammatory processes. The C4A and C4B genes, encoding the two isoforms of complement 4, are located in the nuclear serine/threonine protein kinase‐C4A or B gene‐cytochrome 21‐hydroxylase‐tenascin X ...
Zsolt Ronai, Agnes Szilágyi
exaly   +3 more sources

DNA methylation and copy number variation of the complement C4A gene in schizophrenia

Gene Reports, 2022
The complement gene C4A has been implicated in schizophrenia through genome-wide association studies (GWAS) and, in vitro and animal studies. However, few studies have examined epigenetic modification of the C4A gene in schizophrenia.
Abdull Jalil Mohd Asyraf, Abd Rahim Nour El Huda, Mohd Noor Hanisah, Harun Noorul Amilin, A. Talib Norlelawati   +4 more
openaire   +2 more sources

Deregulation of complement components C4A and CSMD1 peripheral expression in first-episode psychosis and links to cognitive ability

European Archives of Psychiatry and Clinical Neuroscience, 2022
Up-regulation of the complement component 4A (C4A) in the brain has been associated with excessive synaptic pruning and increased schizophrenia (SZ) susceptibility.
Alex Hatzimanolis, Maria Gazouli, Pentagiotissa Stefanatou   +2 more
exaly   +2 more sources

Complement-activation fragment C4a mediates effector functions by binding as untethered agonist to protease-activated receptors 1 and 4

Proceedings of the National Academy of Sciences of the United States of America, 2017
C4a is a small protein released from complement component C4 upon activation of the complement system's classical and lectin pathways, which are important constituents of innate immune surveillance.
Daniel Ricklin, John Lambris, Hongbin Wang   +2 more
exaly   +2 more sources

Elevated plasma C4a levels in multiple sclerosis correlate with disease activity

Journal of Neuroimmunology, 2010
Complement plays a pivotal role in the pathogenesis of multiple sclerosis. C4a, an activated fragment of complement component C4, has been linked to disease activity.
Neil Robertson, Paul Morgan, Svetlana Hakobyan   +2 more
exaly   +2 more sources

The Phenotype of SLE Associated with Complete Deficiency of Complement Isotype C4A

Journal of Clinical Immunology, 1998
Complete deficiency of the complement C4A isotype is a known genetic risk factor for systemic lupus erythematosus (SLE). The disease phenotype of C4A-deficient patients has never been defined. Among 200 patients with SLE from five centers, 18 (9%) with C4A deficiency were identified.
T R, Welch, C, Brickman, N, Bishof, S, Maringhini, M, Rutkowski, M, Frenzke, N, Kantor   +6 more
openaire   +2 more sources

Insights into the Antibacterial Properties of Complement Peptides C3a, C4a, and C5a across Vertebrates

The Journal of Immunology, 2022
Abstract Complement peptides C3a, C4a, and C5a are important components of innate immunity in vertebrates. Although they diverged from a common ancestor, only C3a and C4a can act as antibacterial peptides in Homo sapiens, suggesting that C5a has evolved into a purely chemotactic molecule; however, the antibacterial properties of C3a, C4a,
Xu-Jie Zhang, Ya-Qin Zhong, Zi-You Ma, Ya-Zhen Hu, Jian-Guo Su, Yong-An Zhang   +5 more
openaire   +2 more sources

Glomerular deposition of the complement C4 isotypes C4A and C4B in glomerulonephritis

Nephrology Dialysis Transplantation, 1996
Complement C4 is a component of the classical complement pathway, which is a major mediator of inflammation in many forms of glomerulonephritis. The two isoforms of C4-C4A and C4B-differ in their physicochemical and functional properties.The glomerular deposition of C4A and C4B was investigated in 39 cases of glomerulonephritis with classical pathway ...
K, Lhotta, A, Schlogl, F, Kronenberg, M, Joannidis, P, Konig   +4 more
openaire   +2 more sources

Complement Components C4A and C4B in Human Lupus

2005
For over half a century low serum complement C4 concentrations have been recognized as a manifestation of systemic lupus erythematosus (SLE). However, the role of C4 in human SLE remains elusive. This is partly because of the unusually complex C4 genetics with frequent variations in gene number, gene size, protein isoforms, and expression levels.
Yan Yang, Erwin K. Chung, Karl Lhotta, Yee Ling Wu, Gloria C. Higgins, Robert M. Rennebohm, Lee A. Hebert, Daniel J. Birmingham, Brad H. Rovin, C. Yung Yu   +9 more
openaire   +1 more source