Results 161 to 170 of about 11,655 (197)
Some of the next articles are maybe not open access.
Complement C3a and C4a Increased in Plasma of Patients with Aspirin-induced Asthma
American Journal of Respiratory and Critical Care Medicine, 2006Abstract Rationale Aspirin-induced asthma (AIA) is a distinct clinical syndrome that affects up to 10% of adults with asthma. Although eicosanoid metabolites appear to play an important role in AIA, the exact pathogenic mechanism for the syndrome remains obscure.
Taiyoun Rhim +2 more
exaly +3 more sources
DNA methylation and copy number variation of the complement C4A gene in schizophrenia
Gene Reports, 2022Abd Rahim Nour El Huda +1 more
exaly +2 more sources
Human Complement Components C4A and C4B Genetic Diversities: Complex Genotypes and Phenotypes
Current Protocols in Immunology, 2005AbstractThis unit describes methods that can accurately determine the genotypes and phenotypes of human complement components C4A and C4B. Specifically, they allow investigators to determine how many C4 genes are present in a diploid genome of a human subject and to quantify how many of them encode C4A proteins and how many of them encode C4B proteins.
Erwin K Chung, Yee Ling Wu, Bi Zhou
exaly +3 more sources
The Phenotype of SLE Associated with Complete Deficiency of Complement Isotype C4A
Journal of Clinical Immunology, 1998Complete deficiency of the complement C4A isotype is a known genetic risk factor for systemic lupus erythematosus (SLE). The disease phenotype of C4A-deficient patients has never been defined. Among 200 patients with SLE from five centers, 18 (9%) with C4A deficiency were identified.
T R, Welch +6 more
openaire +2 more sources
The Journal of Immunology, 2022
Abstract Complement peptides C3a, C4a, and C5a are important components of innate immunity in vertebrates. Although they diverged from a common ancestor, only C3a and C4a can act as antibacterial peptides in Homo sapiens, suggesting that C5a has evolved into a purely chemotactic molecule; however, the antibacterial properties of C3a, C4a,
Xu-Jie Zhang +5 more
openaire +2 more sources
Abstract Complement peptides C3a, C4a, and C5a are important components of innate immunity in vertebrates. Although they diverged from a common ancestor, only C3a and C4a can act as antibacterial peptides in Homo sapiens, suggesting that C5a has evolved into a purely chemotactic molecule; however, the antibacterial properties of C3a, C4a,
Xu-Jie Zhang +5 more
openaire +2 more sources
Glomerular deposition of the complement C4 isotypes C4A and C4B in glomerulonephritis
Nephrology Dialysis Transplantation, 1996Complement C4 is a component of the classical complement pathway, which is a major mediator of inflammation in many forms of glomerulonephritis. The two isoforms of C4-C4A and C4B-differ in their physicochemical and functional properties.The glomerular deposition of C4A and C4B was investigated in 39 cases of glomerulonephritis with classical pathway ...
K, Lhotta +4 more
openaire +2 more sources
Electrophoresis, 2006
AbstractComplement component 4 (C4) is an important plasma protein playing a major role in the human defense mechanism against infectious diseases and inflammatory processes. The C4A and C4B genes, encoding the two isoforms of complement 4, are located in the nuclear serine/threonine protein kinase‐C4A or B gene‐cytochrome 21‐hydroxylase‐tenascin X ...
Agnes Szilágyi +2 more
exaly +3 more sources
AbstractComplement component 4 (C4) is an important plasma protein playing a major role in the human defense mechanism against infectious diseases and inflammatory processes. The C4A and C4B genes, encoding the two isoforms of complement 4, are located in the nuclear serine/threonine protein kinase‐C4A or B gene‐cytochrome 21‐hydroxylase‐tenascin X ...
Agnes Szilágyi +2 more
exaly +3 more sources
Complement Components C4A and C4B in Human Lupus
2005For over half a century low serum complement C4 concentrations have been recognized as a manifestation of systemic lupus erythematosus (SLE). However, the role of C4 in human SLE remains elusive. This is partly because of the unusually complex C4 genetics with frequent variations in gene number, gene size, protein isoforms, and expression levels.
Yan Yang +9 more
openaire +1 more source
Complexes of IgG molecules and C3a and C4a complement components in human serum
European Journal of Immunology, 1992AbstractA heterogeneous group of proteins was separated from human serum IgG using 5 M guanidine hydrochloride solution in 0.1 M acetic acid. The protein mixture was fractionated by reverse‐phase high‐performance liquid chromatography and two proteins were isolated and identified as the C3a and C4a complement components (anaphylatoxins) according to ...
R, Nezlin, A, Freywald
openaire +2 more sources
Complement Activation Products C3a and C4a as Endogenous Antimicrobial Peptides
International Journal of Peptide Research and Therapeutics, 2009All vertebrate species are constantly challenged by infectious agents and pathogens. In order to fight these infectious agents the human host has developed a sophisticated and powerful immune defense. The complement system, which represents the first defense line of innate immunity is activated immediately, within seconds.
Peter F. Zipfel, Michael Reuter
openaire +1 more source