Results 171 to 180 of about 11,655 (197)

DR3 and nonDR3 associated complement component C4A deficiency in systemic lupus erythematosus

Clinical Immunology and Immunopathology, 1991
The molecular basis of complement component C4A deficiency in white U.S. and Mexican patients with systemic lupus erythematosus (SLE) was studied. Genomic DNA from SLE patients and non-SLE controls was analyzed for restriction fragments using HindIII and a 5' C4 cDNA probe.
A, Kumar, P, Kumar, P H, Schur
openaire   +2 more sources

Complement Factors C3a, C4a, and C5a in Chronic Obstructive Pulmonary Disease and Asthma

American Journal of Respiratory Cell and Molecular Biology, 2004
Abstract Studies of animal models have shown that the activation of the complement system could have a role in chronic obstructive pulmonary disease (COPD) and asthma by promoting inflammation and enhancing airway hyperresponsiveness. We sought to determine whether the levels of complement factors C3a, C4a, and C5a are elevated at the
Mateja M, Marc, Peter, Korosec, Mitja, Kosnik, Izidor, Kern, Matjaz, Flezar, Stanislav, Suskovic, Jurij, Sorli   +6 more
openaire   +2 more sources

Comparative Structural Anatomy of the Complement Anaphylatoxin Proteins C3a, C4a and C5a

Enzyme, 1986
The anaphylatoxins are a family of proteins produced during the course of complement activation as the result of cleavage by specific serine proteases. These proteins are involved in a variety of biological functions, including inflammation. Comparative modeling techniques have been used to produce structures for C4a and C5a from the crystal structure ...
openaire   +2 more sources

Allelic distribution of complement components BF, C4A, C4B, and C3 in Psoriasis vulgaris

Immunology Letters, 2002
Psoriasis vulgaris is a multifactorial disease; the strongest association was established with the HLA complex. The actual disease-predisposing gene(s) has not been identified yet, but several genes from this region were examined in addition to HLA-C and -B.
Maria, Cisło, Jolanta, Hałasa, Feliks, Wasik, Piotr, Nockowski, Magdalena, Prussak, Maria, Mańczak, Piotr, Kuśnierczyk   +6 more
openaire   +2 more sources

Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients

Current Alzheimer Research, 2017
Background/Objectives: Increasing evidence suggests the importance of neuroinflammation in the pathogenesis of Alzheimer’s disease (AD), which is a complex neurodegenerative disorder. Complement activation occurs in the brain of patients with AD and seems to contribute to an important local inflammatory state. Increased expression of the fourth serum
Michele, Zorzetto, Francesca, Datturi, Laura, Divizia, Cristiana, Pistono, Ilaria, Campo, Annalisa, De Silvestri, Mariaclara, Cuccia, Giovanni, Ricevuti   +7 more
openaire   +2 more sources

Complement component C4A and apolipoproteinA-I in plasmas as biomarkers of the severe, early-onset preeclampsia

Molecular BioSystems, 2011
Abstract Preeclampsia is a common pregnancy complication that is associated with maternal perinatal morbidity and mortality. Because of its early onset (before 34 weeks) and the potential for serious outcomes, severe, early-onset preeclampsia (sePE) should be regarded as a different form of preeclampsia.
Huanling, Zhang, Yi, Zhang, Fu, Yang, Li, Li, Shufeng, Liu, Zengnian, Xu, Junxia, Wang, Shuhan, Sun   +7 more
openaire   +2 more sources

Activated complement components C3a and C4a in cerebrospinal fluid and plasma following subarachnoid hemorrhage

Journal of Neurosurgery, 1989
✓ The cerebrospinal fluid (CSF) and plasma levels of the complement components C3a and C4a in 40 patients suffering from subarachnoid hemorrhage (SAH) were quantitated by radioimmunoassay. Serial measurements of the lumbar CSF levels revealed that the C3a and C4a levels were significantly elevated in the initial stage of SAH, but decreased rapidly ...
H, Kasuya, T, Shimizu
openaire   +2 more sources

RELATIVE CONTRIBUTIONS OF HLA-DQA AND COMPLEMENT C4A LOCI IN DETERMINING SUSCEPTIBILITY TO SYSTEMIC LUPUS ERYTHEMATOSUS

Rheumatology, 1995
The objective of this study was to reassess the role of C4A null alleles in systemic lupus erythematosus (SLE) susceptibility after taking into account the association of DQA*0501 with this disease. The frequency of C4A null alleles in 82 SLE patients and 59 controls was determined using both immunofixation and a TaqI RFLP method.
Davies, E. J., Steers, G., Ollier, W. E R, Grennan, D. M., Cooper, R. G., Hay, E. M., Hillarby, M. C.   +6 more
openaire   +3 more sources

Role of complement C4A in developmental synaptic pruning

Molecular Immunology, 2018
Jessy Presumey, Allison Bialas, Beth Stevens, Steve McCarroll, Michael Carroll   +4 more
openaire   +1 more source

[Inborn deficiency of complement C4A and C4B isotypes in persons infected with Chlamydia].

Voprosy meditsinskoi khimii, 2001
The difference in the functional activity of the isotypes A and B of component C4 of human complement was used to determine their ratio to detect the inherited deficiency of the isotypes. The frequency of deficiency in healthy persons blood donors was equal for C4A and C4B (0.14 for each isotype), i.e.
L V, Kozlov, T A, Skirda, T G, Skorokhodova, V M, Lakhtin, T N, Batalova, V A, Guzova   +5 more
openaire   +1 more source