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Human Complement C4B Allotypes and Deficiencies in Selected Cases With Autoimmune Diseases [PDF]

Frontiers in Immunology, 2021
Human complement C4 is one of the most diverse but heritable effectors for humoral immunity. To help understand the roles of C4 in the defense and pathogenesis of autoimmune and inflammatory diseases, we determined the bases of polymorphisms including ...
Danlei Zhou, Danlei Zhou, Michael Rudnicki, Gilbert T. Chua, Simon K. Lawrance, Simon K. Lawrance, Bi Zhou, Bi Zhou, Joanne L. Drew, Fatima Barbar-Smiley, Fatima Barbar-Smiley, Taylor K. Armstrong, Miranda E. Hilt, Daniel J. Birmingham, Werner Passler, Jeffrey J. Auletta, Jeffrey J. Auletta, Sasigarn A. Bowden, Sasigarn A. Bowden, Robert P. Hoffman, Robert P. Hoffman, Yee Ling Wu, Wael N. Jarjour, Chi Chiu Mok, Stacy P. Ardoin, Stacy P. Ardoin, Stacy P. Ardoin, Yu Lung Lau, Chack Yung Yu, Chack Yung Yu, Chack Yung Yu   +30 more
doaj   +7 more sources

A case report of complement C4B deficiency in a patient with steroid and IVIG-refractory anti-NMDA receptor encephalitis [PDF]

BMC Neurology, 2020
Background Complement C4A or C4B deficiency has never been reported in autoantibody-associated encephalitides patient. Here we present a case of anti-N-methyl- D-aspartate (NMDA) receptor encephalitis associated with homozygous C4B deficiency, who did ...
Gilbert T. Chua, Danlei Zhou, Alvin Chi Chung Ho, Sophelia Hoi Shan Chan, Chack Yung Yu, Yu Lung Lau   +5 more
doaj   +5 more sources

Multifaceted Activities of Seven Nanobodies against Complement C4b. [PDF]

J Immunol, 2022
Cleavage of the mammalian plasma protein C4 into C4b initiates opsonization, lysis, and clearance of microbes and damaged host cells by the classical and lectin pathways of the complement system. Dysregulated activation of C4 and other initial components
De la O Becerra KI, Oosterheert W, van den Bos RM, Xenaki KT, Lorent JH, Ruyken M, Schouten A, Rooijakkers SHM, van Bergen En Henegouwen PMP, Gros P.   +9 more
europepmc   +9 more sources

Serum complement C4b, fibronectin, and prolidase are associated with the pathological changes of pulmonary tuberculosis. [PDF]

BMC Infect Dis, 2014
BackgroundMycobacterium tuberculosis infection can activate the immune system, leading to characteristic pathological changes such as inflammatory granuloma, caseous necrosis, and cavity formation.MethodsClinical data of 187 cases of pulmonary ...
Wang C, Li YY, Li X, Wei LL, Yang XY, Xu DD, Jiang TT, Li ZJ, Chen ZL, Zhang X, Liu JY, Ping ZP, Li JC.   +12 more
europepmc   +4 more sources

The Pneumococcal Surface Proteins PspA and PspC Sequester Host C4-Binding Protein To Inactivate Complement C4b on the Bacterial Surface. [PDF]

Infect Immun, 2019
Complement is a critical component of antimicrobial immunity. Various complement regulatory proteins prevent host cells from being attacked. ABSTRACT Complement is a critical component of antimicrobial immunity.
Haleem KS, Ali YM, Yesilkaya H, Kohler T, Hammerschmidt S, Andrew PW, Schwaeble WJ, Lynch NJ.   +7 more
europepmc   +2 more sources

Domain structure of human complement C4b extends with increasing NaCl concentration: implications for its regulatory mechanism [PDF]

Biochemical Journal, 2016
During the activation of complement C4 to C4b, the exposure of its thioester domain (TED) is crucial for the attachment of C4b to activator surfaces. In the C4b crystal structure, TED forms an Arg(104)-Glu(1032) salt bridge to tether its neighbouring ...
Fung, KW, Gor, J, Perkins, SJ, Swann, MJ, Wright, DW   +4 more
core   +3 more sources

Borrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components. [PDF]

PLoS ONE, 2013
Spirochetes belonging to the Borrelia (B.) burgdorferi sensu lato complex differ in their resistance to complement-mediated killing, particularly in regard to human serum.
Jasmin Schwab, Claudia Hammerschmidt, Dania Richter, Christine Skerka, Franz-Rainer Matuschka, Reinhard Wallich, Peter F Zipfel, Peter Kraiczy   +7 more
doaj   +9 more sources

Elevated serum complement levels and higher gene copy number of complement C4B are associated with hypertension and effective response to statin therapy in childhood-onset systemic lupus erythematosus (SLE)

Lupus Science and Medicine, 2019
Objective Systemic lupus erythematosus (SLE) features high frequency of cardiovascular disease (CVD) and fluctuating complement levels. The clinical trial Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) aimed to evaluate whether ...
Evan Mulvihill, Stacy Ardoin, Susan D Thompson, Bi Zhou, Gakit Richard Yu, Emily King, Nora Singer, D M Levy, Hermine Brunner, Yee Ling Wu, Haikady N Nagaraja, Laura Eve Schanberg, Chack-Yung Yu   +12 more
doaj   +2 more sources

Structural and Functional Analysis of Porcine CR1-like Proteins in C4b-Mediated Immune Responses [PDF]

Veterinary Sciences
The complement system is crucial for immune defense, linking innate and adaptive immunity. In the classical and lectin pathways, C4 is split into C4b, triggering opsonization, lysis, and the removal of pathogens and damaged cells. Dysregulated activation
Wei Yin, Nan Wang, Jingze Li, Haoxiang Yao, Qiongyu Li, Hongquan Li, Kuohai Fan, Jia Zhong, Zhenbiao Zhang, Na Sun, Panpan Sun, Huizhen Yang, Jianzhong Wang, Yaogui Sun   +13 more
doaj   +2 more sources

In vitro complement activation via nucleocapsid and spike proteins of SARS-CoV-2 in COVID-19 patients [PDF]

Scientific Reports
In the overactivation of the complement, the role of classical pathway is still not thoroughly investigated in COVID-19. Our aim was to examine the connection between SARS-CoV-2-specific antibodies, in vitro complement activation, and in vivo complement ...
Petra Kiszel, János Miklós, Erika Kajdácsi, György Sinkovits, László Cervenak, Zoltán Prohászka   +5 more
doaj   +2 more sources