Results 1 to 10 of about 8,570 (135)

Human Complement C4B Allotypes and Deficiencies in Selected Cases With Autoimmune Diseases [PDF]

Frontiers in Immunology, 2021
Human complement C4 is one of the most diverse but heritable effectors for humoral immunity. To help understand the roles of C4 in the defense and pathogenesis of autoimmune and inflammatory diseases, we determined the bases of polymorphisms including ...
Danlei Zhou, Danlei Zhou, Michael Rudnicki, Gilbert T. Chua, Simon K. Lawrance, Simon K. Lawrance, Bi Zhou, Bi Zhou, Joanne L. Drew, Fatima Barbar-Smiley, Fatima Barbar-Smiley, Taylor K. Armstrong, Miranda E. Hilt, Daniel J. Birmingham, Werner Passler, Jeffrey J. Auletta, Jeffrey J. Auletta, Sasigarn A. Bowden, Sasigarn A. Bowden, Robert P. Hoffman, Robert P. Hoffman, Yee Ling Wu, Wael N. Jarjour, Chi Chiu Mok, Stacy P. Ardoin, Stacy P. Ardoin, Stacy P. Ardoin, Yu Lung Lau, Chack Yung Yu, Chack Yung Yu, Chack Yung Yu   +30 more
doaj   +5 more sources

Multifaceted Activities of Seven Nanobodies against Complement C4b. [PDF]

J Immunol, 2022
Abstract Cleavage of the mammalian plasma protein C4 into C4b initiates opsonization, lysis, and clearance of microbes and damaged host cells by the classical and lectin pathways of the complement system. Dysregulated activation of C4 and other initial components of the classical pathway may cause or aggravate pathologies, such as ...
De la O Becerra KI, Oosterheert W, van den Bos RM, Xenaki KT, Lorent JH, Ruyken M, Schouten A, Rooijakkers SHM, van Bergen En Henegouwen PMP, Gros P.   +9 more
europepmc   +6 more sources

A case report of complement C4B deficiency in a patient with steroid and IVIG-refractory anti-NMDA receptor encephalitis [PDF]

BMC Neurology, 2020
Background Complement C4A or C4B deficiency has never been reported in autoantibody-associated encephalitides patient. Here we present a case of anti-N-methyl- D-aspartate (NMDA) receptor encephalitis associated with homozygous C4B deficiency, who did ...
Gilbert T. Chua, Danlei Zhou, Alvin Chi Chung Ho, Sophelia Hoi Shan Chan, Chack Yung Yu, Yu Lung Lau   +5 more
doaj   +2 more sources

Structural and Functional Analysis of Porcine CR1-like Proteins in C4b-Mediated Immune Responses [PDF]

Veterinary Sciences
The complement system is crucial for immune defense, linking innate and adaptive immunity. In the classical and lectin pathways, C4 is split into C4b, triggering opsonization, lysis, and the removal of pathogens and damaged cells. Dysregulated activation
Wei Yin, Nan Wang, Jingze Li, Haoxiang Yao, Qiongyu Li, Hongquan Li, Kuohai Fan, Jia Zhong, Zhenbiao Zhang, Na Sun, Panpan Sun, Huizhen Yang, Jianzhong Wang, Yaogui Sun   +13 more
doaj   +2 more sources

Complement profiling for treatment outcomes in pulmonary TB [PDF]

Frontiers in Immunology
IntroductionThe complement system plays a vital role in the immune response against tuberculosis (TB), aiding in the recognition and clearance of Mycobacterium tuberculosis.
Nathella Pavan Kumar, Nathella Pavan Kumar, Arul Nancy P., Arul Nancy P., Syed Hissar, Shanmugam Sivakumar, Vijay Viswanathan, Ramalingam Bethunaickan, Ramalingam Bethunaickan, Hardy Kornfeld, Subash Babu, Subash Babu   +11 more
doaj   +2 more sources

In vitro complement activation via nucleocapsid and spike proteins of SARS-CoV-2 in COVID-19 patients [PDF]

Scientific Reports
In the overactivation of the complement, the role of classical pathway is still not thoroughly investigated in COVID-19. Our aim was to examine the connection between SARS-CoV-2-specific antibodies, in vitro complement activation, and in vivo complement ...
Petra Kiszel, János Miklós, Erika Kajdácsi, György Sinkovits, László Cervenak, Zoltán Prohászka   +5 more
doaj   +2 more sources

Increased frequency of complement C4B deficiency in rheumatoid arthritis. [PDF]

Arthritis Rheum, 2012
AbstractObjectiveTo assess the copy number variation of complement C4A and C4B genes in patients with rheumatoid arthritis (RA).MethodsDNA samples were obtained from 299 patients and controls and analyzed for copy number variation of total complement C4, C4A, and C4B genes. The results were compared by chi‐square analysis, and odds ratios (ORs) and 95%
Rigby WF, Wu YL, Zan M, Zhou B, Rosengren S, Carlson C, Hilton W, Yu CY.   +7 more
europepmc   +4 more sources

Real-time PCR quantification of human complement C4A and C4B genes [PDF]

BMC Genetics, 2006
Background The fourth component of human complement (C4), an essential factor of the innate immunity, is represented as two isoforms (C4A and C4B) in the genome.
Fust George, Szilassy Denes, Blasko Bernadett, Szilagyi Agnes, Sasvari-Szekely Maria, Ronai Zsolt   +5 more
doaj   +3 more sources

Differential complement pathways and components in the clinical spectrum of systemic lupus erythematosus [PDF]

Arthritis Research & Therapy
Objectives The precise contributions of the classical (CP), lectin (LP), and alternative (AP) pathways to systemic lupus erythematosus (SLE) remain incompletely understood.
Haijun Ma, Qingfeng Yin, Huifang Li, Minghao Guo   +3 more
doaj   +2 more sources

Structural Insights Into Complement Inhibition: Visualizing Distinct Binding Modes of C4b-Binding Protein Complexes With C4b and SAP. [PDF]

Mol Cell Proteomics
C4b-binding protein (C4BP) is an innate immune inhibitor found in serum. Human C4BP adopts spider-like higher-order structures (HOS) formed by disulfide-linked C4BPα and C4BPβ chains that non-covalently bind vitamin K-dependent protein S (ProS). These spider-like structures can form even larger complexes as C4BP interacts with other, mostly complement ...
Kadavá T, Strasser J, Marefat M, Yin VC, Preiner J, Trouw LA, Heck AJR.   +6 more
europepmc   +3 more sources